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Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_3585_Библиотеки_им_академика_М_И_Перельмана

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4.6 Case Study
a
b
241
KBI : LAD 3.0 mm×LCX 3.5mm 14 atm
LAD : POBA (3.0×20 mm) 18 atm
LCX : POBA (3.5×20 mm) 18 atm
KBI : LAD 3.0 mm×LCX 3.5 mm 14 atm
c
Fig. 4.34 KBI after culotte stenting. (a) Rewiring of the SB (LAD) was done via the Crusade catheter. (b) A 3.0-mm balloon in the LAD and a
3.5-mm balloon in the LCX were inated alternately at high pressure, and then were inated simultaneously (KBI). (c) Final angiography
Mitsudo’s Non-pushing PCI Techniques
5
My 33years of experience with PCI have taught me much, including the essential importance of non-pushing PCI techniques. Pushing devices forcibly may lead to injury in various ways because of stress on the target vessel. Although a device cannot be advanced at all without apply­ing some force, the maximum tolerable force should be estimated (i.e., the force that can be applied to a device without causing damage/deformation), and force exceeding this threshold should never be applied. In addition, meth­ods for advancing devices with minimum force should be determined. For example, it may be necessary to push hard on a device if it becomes blocked. Therefore, avoiding this situation is one of the ways to minimize the force required to advance a device.
5.1 When Is Pushing Allowed?
In general, I do not recommend forcibly pushing a device to advance it. However, there is one situation in which push­ing is the only option and thus is permitted. This is when it proves difcult to advance a balloon or microcatheter across a lesion after successful wire crossing.
5.1.1 Microcatheter
It may be possible to cross a lesion, including one requir­ing rotablation, with a 0.014 inch guidewire, but not with a microcatheter. However, the microcatheter can often cross the lesion if the guidewire is exchanged for another that pro­vides greater support.
During PCI for CTO, it is often necessary to rotate the microcatheter in addition to pushing it forward with minimal force in order to advance antegradely into a lesion, to retro­gradely cross a collateral channel, or to deliver the catheter into a lesion requiring rotablation that has been crossed by a guidewire with microcatheter support.
Unlike the Tornus catheter, microcatheters must not be rotated excessively in the same direction because these cath­eters generally cannot tolerate the torque of excessive rota­tion. For example, the Caravel microcatheter only tolerates up to three clockwise or counterclockwise rotations. When more than three rotations are performed with the tip xed, the shaft of this catheter tends to bulge and may become deformed. If this occurs after successfully tracking a channel, it may prevent withdrawal of the microcatheter. Therefore, you should never perform more than three clockwise or counterclockwise rotations of the Caravel microcatheter in succession. Of course, it is possible to perform three coun­terclockwise rotations initially and then repeat alternating cycles of six clockwise and six counterclockwise rotations. The Corsair microcatheter is better able to tolerate rotation, but it is safer to limit the number of successive clockwise or counterclockwise rotations to about ten with the Corsair and most other microcatheters.
5.1.2 Small-Diameter Balloon Catheter
If a microcatheter cannot be advanced, it should be exchanged for a small-diameter balloon catheter. Balloon catheters from
1.0 to 1.25mm in diameter with good crossability are avail­able. Monorail balloon catheters can only be pushed and can hardly be rotated. Therefore, you should use a balloon cath­eter that is suitable for the characteristics of the lesion.
Attempting to forcibly advance balloon that had become blocked will sometimes deform the balloon and enlarge its prole, preventing further advancement. Most of the recently developed balloon catheters have been modied to be more resistant to such deformation, but this problem has not been completely overcome. Therefore, bench testing should be performed to determine the force that can be applied before each balloon undergoes deformation.
A balloon with a stiffer tip is better for a hard and rel­atively linear lesion, since it can be advanced despite the
© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2021 K. Mitsudo, Non-Pushing PCI Techniques, https://doi.org/10.1007/978-981-15-7043-8_5
243
244
ab
hardness of the lesion. If the balloon has a soft tip, it will easily become deformed (Fig.5.1), and you cannot advance a balloon with a deformed tip no matter how hard you push it. However, it may not be possible to advance a balloon with a stiff tip through a tortuous lesion because it is signi­cantly biased toward the outer side of the vessel (Fig.5.2b). On the other hand, such a lesion can often be crossed easily by a balloon with a soft tip that has little or no gap between its tip and the guidewire (Fig.5.2c).
It is often difcult to advance a balloon through a hard and tortuous lesion. Therefore, it is usually better to exchange the guidewire for another with a stiff shaft that can provide greater support to straighten a tortuous vessel (Fig.5.3) and then advance a balloon with a stiff tip. This can result in successful crossing of the lesion, but the balloon might be blocked by hard tissue within a long CTO.In this situation, dilating the entire proximal part of the occlusion with a small balloon will often facilitate easy advancement of the balloon catheter. Dilating the proximal part of the occlusion presum­ably reduces friction between the balloon and the occluded vessel, leading to better transmission of force, or changes the direction of the balloon at the point of blockade (Fig.5.4).
5 Mitsudo’s Non-pushing PCI Techniques
a
b
c
Fig. 5.2 Advancing a balloon through a hard and tortuous lesion (a). It
can be difcult to advance a balloon with a stiffer tip because it is biased toward the outer side of the vessel (b). A balloon with a very small gap between its tip and the guidewire (providing better trackabil­ity) can often cross the lesion (c)
Fig. 5.1 Flaring of the balloon tip. If a balloon with a soft tip is pushed
forcibly into a hard lesion, the tip may become deformed and are out (a). If the tip becomes even slightly ared, it will be more difcult to
advance the balloon through the lesion. Therefore, about 0.3mm of the tip should be cut off (b) or the balloon should be exchanged for one with a stiffer tip
5.1 When Is Pushing Allowed?
Fig. 5.3 Crossing a tortuous hard lesion. The guidewire should be
exchanged for one with a stiffer shaft that provides greater support and straightens the tortuous lesion to facilitate crossing by the balloon
Fig. 5.4 Crossing a long hard lesion. If the proximal part of a long hard
lesion is dilated, this will reduce friction between the balloon and the lesion and/or alter the direction of the balloon tip at the site of blockade to assist with crossing the lesion
5.1.3 Tornus Catheter
After failing to advance a balloon catheter across a lesion, a Tornus catheter should be tried. Three models of the Tornus catheter are available (2.1-Fr, 88 Flex, and Pro 2.1-Fr), all of which have a shaft composed of metal wires but are slightly different with respect to structure and characteristics (Fig.5.5). I always choose the Tornus Pro if there is no par­ticular contraindication.
The Tornus Pro has a 2.1-Fr shaft and its tip size is 0.025 inches. The Tornus 88 Flex is slightly larger, with a 2.6-Fr shaft and a tip size of 0.028 inches. If the entrance of the lesion is large enough to accommodate the 0.028 inch tip
245
of the 88 Flex, its thicker shaft produces greater torque that promotes advancement. The Tornus Pro 2.1 Fr has the small­est tip (0.024 inches) and can be used for a tight stenosis that cannot be entered with the other Tornus models.
The Tornus cannot be advanced by rotation alone. To advance it into a tight stenosis, you have to simultaneously rotate the catheter and push it in quite strongly. In the RCA, even a deeply engaged guiding catheter may not provide suf­cient support for the Tornus. Therefore, an anchoring bal­loon is often used in combination with the Tornus for RCA lesions.
There are several tips for manipulating the Tornus cathe­ter. You should usually rotate a Tornus catheter counterclock­wise in a stepwise fashion with the right hand while pushing it in with the left hand (Fig.
5.6). After one or two rotations,
you should stop pushing with the left hand and return the right hand to its original position. You should then relax the left hand to release the Tornus and subsequently rotate it counterclockwise again. These processes are repeated until the catheter has received a total of 20 to 30 rotations. You should then completely relax the left hand to release the accumulated torque. The Tornus may advance spontane­ously during torque release. Rotating it as much as possible at once, rather than repeatedly performing small rotations, will help the catheter to advance further.
After crossing has been achieved with the Tornus, most calcied lesions need debulking with a Rotablator, although some mildly calcied lesions may be treated by balloon angioplasty. To perform rotablation, the guidewire should be exchanged for a RotaWire after the Tornus has crossed the lesion. It is usually quite difcult to advance the RotaWire Extra Support guidewire through the Tornus catheter due to strong friction. This is particularly true if the lesion is long, hard, and tortuous (including CTOs), even if the measures described below are tried. It is easier to pass a RotaWire Floppy guidewire through the Tornus catheter.
You must never push a RotaWire forward strongly when advancing it through the Tornus catheter because the wire is likely to become kinked at the hub of the Tornus, mak­ing it impossible to advance further. Even if you manage to successfully pass a kinked RotaWire through the Tornus catheter, the kinking will make it difcult to deliver the RotaBurr and will affect debulking. To pass a RotaWire through the Tornus catheter, you should advance the wire carefully while rotating it. Do not use the attached clip for advancing the guidewire, but use a torquer to apply suf­cient rotation to the wire. You should slide the torquer for­ward from the proximal edge of the RotaWire to near the hub of the Tornus. Advancing the RotaWire successfully may require many rotations, but you must never hurry or push it in forcibly. Instead, step-by-
step advancement of the guidewire while rotating it provides the key to successful delivery through the Tornus catheter.
246
a
ab
b
c
Fig. 5.5 The three Tornus models. (a) Tornus Pro. (b) Tornus. (c)
Tornus 88 Flex
5 Mitsudo’s Non-pushing PCI Techniques
5.1.4 Backup fortheGuiding Catheter
As explained in Chap. 1, a guiding catheter should be selected that has a tip of the optimal size and curvature to maximize backup in the target coronary artery. That is, when the guiding catheter is engaged in the ostium of the target coronary artery, its tip should be parallel with the ostium and its shaft should be supported by the contralateral wall of the sinus of Valsalva so that it provides sufcient support when delivering devices.
If there is no guiding catheter with the optimal tip size/ curvature and if greater back-up is needed, the following methods can be employed to enhance the back-up provided by any guiding catheter.
1. Anchoring technique (see Chap. 1 [p. 14])
2. Deep engagement
Deep engagement of the guiding catheter is an effective method of enhancing backup if the coronary artery ostium has a sufciently large diameter and the vascular anatomy allows the catheter to be positioned coaxially in relation to the ostium (Fig.5.7a). It is relatively easy to achieve deep engagement of a guiding catheter with a small diameter (e.g., 5-Fr) (Fig.5.7b).
However, deep engagement of the guiding cath­eter is associated with a risk of coronary artery injury. Therefore, this method should only be used if the guiding catheter can easily be advanced by rotation alone without pushing it in.
Fig. 5.6 Technique for advancing the Tornus. First, attach a torquer to
the guidewire. Then rotate the Tornus catheter counterclockwise with the right hand while pushing it in with the left hand
Fig. 5.7 Deep engagement of a guiding catheter. (a) To achieve deep
engagement of an Amplatz guiding catheter in the RCA, the catheter should be pulled back slightly while rotating it clockwise so as that the
tip is coaxial to the ostium. (b) It is easier to achieve deep engagement of a guiding catheter with a small diameter because its tip has a small radius of curvature
5.2 Guidewire
247
3. Deep engagement with assistance from an over-the-wire child catheter or GuideLiner
The child-in-mother technique can a useful supplemen-
tary method. However, the over-the-wire child catheter or Guideliner is not always suitable, and you may be unable to use either of them some circumstances. In that situation, you should exchange the current guiding catheter for another catheter with a tip designed to enhance backup. At many cen­ters, it is difcult to always have access to all kinds of guid­ing catheters. Therefore, a guiding catheter can be heated and reshaped with an optimal curve or tip size or any addi­tional three-dimensional changes that maximize backup (see Chap. 1 [Page 12]).
5.2 Guidewire
5.2.1 Fundamentals ofAdvancing
aGuidewire
If the tip of a guidewire is deected by an obstruction, exces­sive force must not be applied to advance it. If a guidewire becomes stuck in a severe stenosis or CTO and if the proxi­mal part of the wire shows deection, too much force must not be applied either. This is my absolute rule for guidewire manipulation. About 90% of procedural problems related to guidewires are attributable to using excessive force when attempting to advance the wire in various situations.
5.2.2 Guidewire Manipulation
A guidewire can be manipulated in four ways, which are pushing it forward, pulling it back, rotating it, and xing its tip. These four manipulations should be combined appro­priately to achieve the optimal wiring strategy for various purposes, such as (1) tracking a clearly visible channel, (2) exploring and tracking an accessible channel, and (3) cross­ing an occlusion.
Whatever wiring strategy is employed, it is of paramount
importance to apply minimal force to the guidewire and to nd a route that allows the wire to be advanced without push­ing hard. If you cannot nd a suitable route, the shape of the guidewire tip should be modied. If even a guidewire with a reshaped tip cannot be advanced, it should be exchanged for another wire that is appropriate for the circumstances, such as a guidewire with greater slipperiness, a guidewire with a tapered tip, a CTO crossing wire with a 0.014 tip, or a CTO crossing wire with a tapered tip. Then you should search
for a route along which the new guidewire can be advanced without pushing it hard by bypassing obstructions.
5.2.3 Rotating andPushing aGuidewire
As explained in relation to PCI for CTO (see Chap. 1), a guidewire can be rotated in two ways, which are (1) xed point rotation and (2) to-and-fro rotation.
To perform to-and-fro rotation of a guidewire, the entire (curved) tip is rotated around its axis (shaft) (Fig.5.8). This method of rotation is often used to advance a guidewire to the entrance of a lesion or through the normal vessel lumen distal to a lesion. The wire is advanced while rapidly rotat­ing it alternately clockwise and counterclockwise. Rotation of the tip is utilized to free the guidewire from irregularities of the vessel wall that have temporarily caught it and thus to minimize the force required to advance it.
If the guidewire becomes stuck while to-and-fro rota­tion is being performed, its tip stops rotating. If this hap­pens, you should immediately stop advancing and rotating the guidewire, because forcible attempts to push the wire forward may cause intimal injury or deviation into the sub­intimal region. In this situation, you should pull the guide­wire back slightly and then try to advance it again. If the guidewire is blocked by a hard lesion, the shaft should be rotated while keeping the tip xed at the point of obstruction (xed point rotation; Fig.5.9), in order to cross the obstruc­tion. This technique is typically used during SB wiring in bifurcation stenting when the guidewire targeting the SB becomes blocked by a stent strut. To assist the guidewire to bypass the obstruction, rotation of 90 degrees should be performed using the torquer without moving the tip of the wire. If the guidewire is advanced with even slightly stron­ger force than optimal during rotation, the tip will easily deviate from the obstruction. If the tip of the guidewire is deected, you should pull it back slightly to straighten the tip. Combining this manipulation with xed point rotation often helps to pass the obstruction.
Fig. 5.8 To-and-fro rotation. A guidewire may be caught by irregulari-
ties of the vessel wall as it is pushed forward, leading to intimal injury if forcible attempts are made to continue advancing it. Performing to­and- fro rotation aims to free the guidewire from such irregularities by alternately rotating it clockwise and counterclockwise
248
Fig. 5.9 Fixed point rotation. For wiring the SB during bifurcation
stenting, the guidewire is advanced to the distal MB and then is pulled back with its tip oriented in the direction of the SB until the tip enters the branch. Applying xed point rotation of 90 degrees to the guide­wire at this stage will help to bypass obstruction by a stent strut so that it enters the SB.If the tip of the guidewire is deected and does not enter the SB, the wire should be pulled back slightly to straighten the tip and xed point rotation should be repeated to bypass the obstruction
5.2.4 Exploration withaGuidewire
If a channel across a CTO is thought to exist but it cannot be conrmed visually, you should try advancing a guidewire with a tapered soft tip in several directions to nd a route along which the wire can go forward without deection.
If the guidewire deviates into a subintimal space while you are attempting to cross a CTO and you can see an inection point, the wire should be pulled back until it is just proximal to that point to bypass the obstruction that led to deviation.
While exploring to nd a route to the SB at a bifurcation after reshaping the tip curve of a guidewire, slight rotation of the wire may be performed. However, such rotation only aims to orient the tip in the desired direction and should be considered as part of exploration.
5 Mitsudo’s Non-pushing PCI Techniques
1. Techniques for wiring a very tortuous vessel are described in detail in Chap. 1.7.8 (see p. 111). Although tortuous ves­sels with target lesions differ from the tortuous collateral channels used in retrograde PCI because of having a larger diameter and fewer bends, a similar approach to wiring is employed. That is, you should reshape a guidewire with a slippery soft tapered tip or non-tapered tip (polymer jack­eted guidewire) to create a very acute (hairpin) tip curve and then should slowly advance the wire while applying nearly xed point rotation (Fig.5.10).
2. Wiring the SB at a bifurcation can be difcult in two situ­ations. One is where the SB is located after a bend in the proximal MB (Fig.5.11a). In this situation, you should follow the steps stated above when choosing and reshap­ing the guidewire for a tortuous vessel. Then you should twist the tip of the guidewire in the opposite direction to orient it toward the SB (Fig.5.11b) and advance the wire slowly. This technique may require considerable experi­ence with PCI.If another guidewire is advanced through the MB rst, it will straighten the vessel and decrease the take-off angle of the SB, which may make it easier for the wire to enter the SB (Fig.
5.11c). A Crusade catheter can
also be used to straighten a tortuous MB (Fig.5.11d).
The other situation that makes wiring the SB difcult is if
the branch arises with reverse angulation (Fig.5.12). While you may follow the same advice for choosing and reshaping the guidewire given in (1) above, the wire will often fail to enter the SB.In this situation, the reverse wire technique can be very useful.
Fig. 5.10 Wiring a very tortuous
vessel. To pass a guidewire through a vessel that is too tortuous to be crossed by a wire with a 0.014­inch tip, a slippery polymer jacketed guidewire should be reshaped to create a hairpin curve at the tip and then advanced while rotating it
5.2.5 Guidewire Selection andSupplementary Wiring Techniques (Crusade Microcatheter, Scoring Balloon [Lacrosse NSE Balloon] Angioplasty, Reverse Wire Technique, etc.)
It may be difcult to advance a guidewire through a very tor­tuous vessel, the SB of a tortuous vessel, a highly angulated SB, an SB distal to a coronary artery aneurysm, or an SB that is just distal to a stenosis. I have summarized the optimal guidewires and wiring strategies for these situations below.
ab
cd
5.2 Guidewire
249
Fig. 5.11 Wiring a side branch (arrow in a). The guidewire is advanced
into the distal MB and then slowly pulled back while orienting its tip toward the SB. To prevent the guidewire from slipping out of the
ostium, the wire should be slowly advanced into the SB while applying rotation (b). Advancing another guidewire or a Crusade catheter into the MB may assist with isolation of the SB (c, d)
250
a
b
c
d
e
5 Mitsudo’s Non-pushing PCI Techniques
5.3.1 Bifurcation Lesions
Entanglement of multiple guidewires in a bifurcation lesion may prevent delivery of a balloon catheter (Fig.5.13). This is most commonly encountered when advancing a previ­ously used balloon catheter to perform post-stenting KBI after rewiring an SB (Fig.5.14). In such a situation, forcibly advancing the balloon catheter will dislocate the entangled guidewires and prevent guidewire crossing or even cause guidewire deformation. If it is difcult to advance a balloon catheter, you should always consider the possibility of guide­wire entanglement.
If a Crusade catheter is used for SB rewiring, guidewire entanglement, if any, will be limited to several millimeters distal to the guidewire exit port of the catheter and entangle­ment is unlikely. Nonetheless, guidewire entanglement can occur even if SB rewiring is performed with a Crusade cathe­ter, probably due to exion or torsion of the guiding catheter. Two guidewires can become entangled even if their proximal topological relationship is always kept constant outside the body.
Therefore, interventionalists need to know countermea­sures for guidewire entanglement. If entanglement of two guidewires prevents advancement of a balloon, the two guidewires should be kept in place and the balloon catheter should be withdrawn. You should then correct the torsion of the two guidewires by rotation in the correct direction (in practice, it can be hard to determine which direction this is) at the O-ring. Subsequently, re-advancing the balloon may
Fig. 5.12 Wiring a side branch with reverse angulation. The reverse
wire technique is used for isolation of the branch
5.3 Balloon Angioplasty (POBA)
To pre-dilate a tight stenosis, it may sometimes be neces­sary to push a balloon catheter into the lesion, but this must not be done with too much force. Pushing a balloon cath­eter strongly into the lesion will deect the proximal shaft of the catheter and apply stress to the vessel wall. Although the extent to which such catheter deection contributes to dissection of the coronary artery proximal to the lesion or progression of stenosis is unclear, I have encountered pro­gression of coronary stenosis that was possibly due to forc­ible advancement of a balloon catheter. Therefore, following the principle of “avoiding potential causes of adverse events whenever possible,” measures should be taken to improve the crossability of a balloon catheter for pre-dilation, such as exchanging the balloon for one with a smaller diameter and inating the new balloon.
resolve guidewire entanglement, although this is not always successful. Another method is to withdraw the guidewire from the distal MB into a balloon catheter that has been advanced to the site of entanglement and then readvance the guidewire for a short distance. This method can resolve guidewire entanglement and allow the balloon to pass into the stent (Fig.5.14c, d).
In this setting, if the tip of the balloon is used to put slight pressure on the site of guidewire entanglement in the MB, withdrawal of the entangled guidewire into the bal­loon will not have much inuence on the balloon’s direc­tion. If the guidewire is subsequently advanced a little from the tip of the balloon, the balloon will usually go forward smoothly into the MB.After withdrawal of the guidewire into the balloon, the balloon may sometimes become ori­ented toward the SB.If this happens, you should pull the balloon back a little and give its tip some freedom. Then you should readvance the balloon while avoiding guide­wire advancement toward the SB or blocking of the wire by stent struts.
a
b
c
d
5.3 Balloon Angioplasty (POBA)
251
5.3.2 Balloon Size, Ination Pressure,
andInation Speed
It is often said that high-pressure balloon ination causes dissection, but is this true? It is completely incorrect if dis­section is taken to mean direct injury of an intact part of the vessel by the balloon (Fig.5.15). The most common causes of dissection after balloon ination are oversizing of the bal-
Fig. 5.13 Guidewire entanglement at a bifurcation lesion. Guidewire
entanglement prevents delivery of a balloon
Fig. 5.14 Guidewire entanglement after SB wiring, precluding deliv-
ery of a previously used balloon to the MB
Although SB rewiring may be performed while avoiding guidewire entanglement, it is recommended to overcome entanglement by withdrawing the guidewire into a balloon that has been advanced to the site of entanglement in the MB and then advancing the balloon to the distal MB.This maneuver can resolve guidewire entanglement and permit smooth delivery of the balloon. As the tip of the balloon is oriented toward the MB, you can smoothly pass the balloon and the guidewire through a stent in the MB if the stent has been well apposed.
loon and excessively rapid ination.
Assume that a balloon is inated in a straight vessel to exactly the luminal diameter so that the vessel wall comes into contact with the balloon but does not undergo expansion (Fig.5.15b). Then balloon ination will not injure the vessel regardless of the pressure employed. In this case, even if the balloon is inated more rapidly, it will never injure the vessel. However, what will occur after ination of a balloon with a larger size than the luminal diameter (Fig.5.15c)? One can eas­ily imagine that ination could cause increasingly severe injury of the vessel as the balloon is inated to a larger size and/or at a higher speed. In a curved vessel, vascular injury due to inating an oversized balloon at excessive speed will predomi­nantly occur at the edges of the balloon where the vessel wall undergoes greater excursion (Fig.
5.15d, e). In a curved vessel,
high-pressure ination of a balloon with low conformability can cause marked vessel wall excursion, and this increases the risk of dissection at the balloon edges. The risk of dissection also largely depends on the speed of balloon ination after ves­sel wall excursion occurs at the balloon edges.
In general, insufcient preparation of the lesion (leading to suboptimal stent expansion) is associated with a high rate of restenosis and with an even higher rate of re-restenosis after repeat PCI for in-stent restenosis. You should remember that there are no satisfactory interventions for treating reste­nosis due to suboptimal stent expansion. Therefore, subop­timal expansion is an event that must be avoided. Because PCI is performed on this basis, it will often be necessary to increase the balloon ination pressure to avoid suboptimal stent expansion. On the other hand, it is not always easy to predict the need for high-pressure balloon angioplasty. If a safe method of performing high-pressure balloon angioplasty is known, it should be employed routinely. I will explain my own method of high-pressure balloon angioplasty next.
To dilate a stenosis (Fig. 5.16a), a balloon (3.0-mm) that matches the luminal diameter of the vessel (3.05-mm) is selected and is inated at its nominal pressure (6 atm). To remove an indentation in the balloon (Fig. 5.16b) and thus avoid insufcient lesion preparation, the pressure is increased to 18atm (RBP plus 4atm), achieving a nal bal­loon diameter of about 3.3mm (Fig.5.16c). There is a risk