Host-pathogen interaction describes the intriguing relationship between a host and its microbe, which is critical to fungal pathogenesis. Fungal infection by Candida species is emerged as a pressing concern within the healthcare sector, reecting the dynamic interplay between the human immune system and opportunistic pathogens. Candida species (spp.) are placed in critical priority and high groups by the WHO fungal pathogen priority list in 2022 (Fisher and Denning 2023). The emergence of drug resistance lately has imparted further credence to the potential threat posed by Candida globally. Candida infections pose a signicant threat to individuals with weakened immune systems, as this typical benign microorganism can transform into a formidable pathogen. According to the SENTRY Antifungal Surveillance program in 2016, reports suggest a decline in Candida albicans infections, whereas a sudden surge takes place in cases of non-albicans species such as Candida gla- brata and Candida auris (Pfaller etal. 2019). Fungal pathogens, in general, are armed with weapons ranging from adhesion and invasion to phenotype switching and metabolic adaptations to navigate the challenges the host environment presents. Survival in a dynamic host environment requires the fungi to alter their protein pool, efciently respond to stressors and administer morphogenetic changes. Central to these strategies are the regulatory mechanisms that control virulence (Staniszewska 2020).