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Chapter 3 / Body Systems
61
water from the side that has a lower concentration of these molecules to the side with the higher concentration. The addition of water effectively lowers the concentration of these chemicals. Most people recognize that oil and water do not mix. Because of its molecular structure, water is not soluble in oil or fat. Although water is not a fat-soluble mol­ecule and it would typically be repelled by the lipid bilayer, water moves through the semipermeable cell membrane. Osmosis is the specific passive transport mechanism by which water crosses the membrane through channel pro­teins to balance concentrations on either side of the mem­brane. The best way to remember which direction water moves through the membrane is the phrase “Water follows concentration” (Fig.3-4B). If there is a higher concentration of solutes outside the cell, water will move out of the cell in an attempt to balance the solutions on either side of the membrane. Conversely, if there is a higher concentration of solutes inside the cell, water will flow into the cell to achieve a balance.
Solutions possess tonicity, the amount of dissolved par­ticles in the solution. A solution whose tonicity is the same as that within our cells is called an isotonic (AHY-soh-TAHN­ik) solution. When an isotonic solution surrounds our cells, water levels within the cells do not change. Intravenous fluids such as Ringer’s lactate and 0.9% saline solution are isotonic solutions that have the same concentrations as our cells, so when they are injected into the bloodstream, the cells do not absorb or eliminate water.
When solutions that do not have the same con­centration as dissolved substances in our cells are intro­duced into our bodies, the water content within the cell is adjusted to maintain a balance on either side of the cell membrane. This homeostatic mechanism is used thera­peutically when medical professionals give patients intra­venous fluids. Hypotonic (HAHY-poh-TAHN-ik) solutions have a lower osmotic pressure (are less concentrated) than the fluid inside our cells and result in water moving into the cell by osmosis. Conditions of dehydration are
sometimes treated with hypotonic solutions, which force water to move into and rehydrate the cells. Hypertonic (HAHY-per-TAHN-ik) solutions are used to treat edema, which is swelling due to an excess of fluid between the cells. The hypertonic solution, often 3% to 5% sodium chloride solution, causes water to move toward the higher concentration, outside the cells, and into the bloodstream (Fig. 3-5). The excess fluid is then processed by the kid­neys and excreted asurine.
Passive Transport Mechanism of Facilitated Diffusion
Facilitated diffusion is a special form of passive membrane transport. Molecules that are too large or that would be repelled by the lipid bilayer use carrier proteins scattered along the membrane as trap doors that allow them to pass through easily. A carrier protein molecule will attach to the oversized molecule, possibly altering its shape or enveloping it, and will pull it through the membrane (see Fig. 3-4C). A good example of facilitated diffusion is the passage of glu­cose through a cell membrane. Glucose is a large molecule used for cellular metabolism that is not fat soluble but can use a carrier protein to get through the membrane.
Passive Transport Mechanism of Filtration
Filtration is another mode of passive transport whereby water and dissolved substances (solutes) are pushed through a membrane by fluid pressure. This process moves the solu­tion from an area of higher pressure to an area of lower pressure, again part of the homeostatic process of keeping a balance on either side of the membrane (see Fig. 3-4D). An example of filtration is urine formation in the kidneys, where the fluid pressure in the blood capillaries is higher than that in the kidney tubules. The difference in pressures forces the solution out of the blood capillaries and into the kidney tubules for elimination.
Figure 3-5. Effects of osmosis
on red blood cells in different concentrations: isotonic, hypotonic, and hypertonic solutions.
Normal
(isotonic)
solution
Hypotonic
solution
Hypertonic
solution
62 INTRODUCTION TO MASSAGE THERAPY
Active Transport Mechanisms
Active transport processes require ATP as a source of energy to move chemicals through a membrane. There are several different situations in which molecules cannot be transport­ed passively and energy must be used to move them:
• Molecules that are too large to pass through the membrane and cannot take advantage of carrier proteins
• Molecules that have to move against the concentra­tion gradient, or from an area where they are lower in concentration to an area of higher concentration
• Molecules that are not fat soluble and cannot take advantage of carrier proteins
Solute pumping is the active transport process that uses energy from the breakdown of ATP to help protein carriers pull amino acids, some sugars, and many ions through the membrane.
Bulk transport is an active transport process that uses energy to package molecules and carry them across the membrane. Exocytosis is the bulk transport mechanism that takes cellular products from the inside of the cell to the out­side of the cell. The products in the cytoplasm are packaged in a sac, the sac is incorporated into the membrane, and the contents of the sac are released into the extracellular fluid (the fluid that surrounds the cell). Mucus is released outside the cell via exocytosis (Fig. 3-6B).
Endocytosis is another bulk transport mechanism that works in the opposite direction of exocytosis. Substances
outside the cell are engulfed, transported inside the cell, and usually digested by enzymes (Fig. 3-6A). Bacteria and dead body cells are managed by the specific form of endocytosis called phagocytosis (FAY-goh-sahy-TOH-sis). When liquids that contain dissolved proteins or fats cannot diffuse through a cell membrane, pinocytosis (PEE-noh-sahy-toh-sis) is the special form of endocytosis that moves them into the cell. The prefix “exo-” means to “move out” and “endo-” means to “move in.”
The cell membrane is a very active component of the cell that is involved in homeostasis, but there are a number of other structures that are equally important.
Cytoplasm
The cytoplasm is the liquid substance inside the plasma membrane that houses most of the cellular activity, com­posed of a gel-like substance called cytosol that contains nutrients, minerals, enzymes, and cytoplasmic organelles suspended in it. The cytoplasm makes up 50% of the cell’s volume and contains everything necessary for protein syn­thesis as well as the enzymes for building and breaking down molecules (Fig. 3-7).
Cytoplasmic Organelles
The cytoplasmic organelles are the metabolic machinery of the cell that keeps the cell alive and dynamic. Organelles, including the nucleus, nucleolus, ribosomes, endoplasmic reticulum, mitochondria, Golgi apparatus, lysosomes, and
Figure 3-6. Bulk transport
mechanisms. (A) Endocytosis. (B) Exocytosis. (Reprinted from Premkumar K. The Massage Connection: Anatomy & Physiology. 2nd ed. Baltimore: Lippincott Williams & Wilkins, 2004.)
Bacterium A
Cytoplasm
Cell membrane
Golgi apparatus
Endocytosis
Lysosomes
Phagosome
Exocytosis
Phagosome fuses with lysosome
Secondary lysosome
B
Chapter 3 / Body Systems
63
Human cell
Microvilli Cell
membrane Mitochondrion
Nuclear membrane
Nucleus
Nucleolus
Centriole
Ribonucleic acid
Ribosomes
Chromatin
Endoplasmic reticulum
Figure 3-7. Components of a cell. (Asset provided by Anatomical
Chart Co.)
Plasma membrane
Golgi apparatus
Cytosol
Lysosome
centrioles, are all suspended in the cytosol. They have differ­ent shapes and functions, and any disruption of their activity will affect the homeostasis of the cell.
The largest organelle is the nucleus (NOOK-lee-us), located somewhere near the center of the cell. The nucleus is the control center for the cell. It is enveloped in a double­layered membrane that is perforated with pores that allow some molecules to pass between the nucleus and the cell. Within the nucleus is a small, spherical structure called a nucleolus (nook-lee-OH-lus) that builds the molecules required for protein synthesis. Occasionally, cells have two nucleoli, if there is a heavy demand for proteins. Among other molecules, the nucleus contains DNA, which is nec­essary for building all proteins. Proteins are necessary com­ponents for building cell structures and carrying out cell functions including cell reproduction.
Outside the nucleus are many organelles suspended in the cytosol that carry out other cellular operations. There are many ribosomes (RAHY-boh-zohmz) that serve as the factory where proteins are put together with the help of enzymes. Some ribosomes are suspended in the cytosol, and some are attached to the rough endoplasmic reticu­lum. Within the cytosol, there are one or more endoplasmic reticula, which are networks of tubes that modify and direct newly made proteins to other cell organelles. The endoplas­mic reticula also manufacture membrane lipids, synthesize and break down cholesterol, and metabolize fat.
Also within the cytosol are several elongated oval organ­elles called mitochondria (MAHY-toh-KON-dree-uh). As the powerhouses of cellular function, mitochondria break down nutrients and release energy. Some of the energy is released
as heat, but most of the energy is converted to ATP mol­ecules through the process of cellular respiration, which is the primary source of energy for cellular metabolism. Because oxygen is required for cellular respiration, the pro­cess is sometimes referred to as aerobic respiration. Without oxygen, cells will suffer and eventually die. Generally, the more active the cell, the more oxygen and energy it requires and the more mitochondria it will have. Muscle cells that get regular exercise increase their numbers of mitochondria to generate more energy for the muscle cell.
The Golgi apparatus is an organelle that resembles a stack of flattened sacs that are suspended in the cytosol. Serving as a sort of packaging plant, the sacs receive proteins by way of the endoplasmic reticulum. The proteins are mod­ified, sorted, and gathered in sacs until the sacs swell to the point that they pinch themselves off and become secretory vesicles. The final destination of the vesicles depends on their contents. Vesicles that contain substances destined for the blood or a body tube fuse with the plasma membrane and expel their contents outside the cell, illustrated above as the active transport mechanism of exocytosis (see Fig. 3-6). Some vesicles contain proteins and phospholipids that are taken to the plasma membrane and become part of its structure.
Some of the smaller cytoplasmic organelles include lyso­somes (LAHY-soh-zohmz) and centrioles (SEN-tree-ohlz). Varied in size, lysosomes are essentially vesicles containing digestive enzymes. Inside the cell, lysosomes engulf and digest cellular waste, bacteria, and unwanted foreign sub­stances. Centrioles are rod-shaped organelles located close to the nucleus that aid in chromosome separation during cell division. Some cells have cilia, which are small, hairlike extensions of the plasma membrane on the outside of the membrane that help sweep objects past the cell. They are located in respiratory and reproductive tracts to push mucus or an egg in a specific direction. An extra-long form of cilium called a flagellum (fluh-JEL-uhm) is a whiplike extension that propels the cell itself. The human sperm cell has a single fla­gellum that moves the sperm from one place to another.
The many structures of a cell, with their many activi­ties, work cooperatively to maintain the life cycle of the entire cell. As part of the whole picture, cells are the tiny building blocks that make up tissues, organs, organ systems, and the organism.

Tissues

A tissue is a group of cells that have a similar structure and work together to accomplish a similar function. There are four basic tissue types, each with a unique structure, a spe­cific function, and its own rate of healing. Structure and function are closely related, following the rule of “form follows function.” Much of healing depends on nutrient delivery and waste removal, so the healing rate tends to
64 INTRODUCTION TO MASSAGE THERAPY
be related to the tissue’s blood supply. Epithelial (EH-pih­THEE-lee-uhl) tissue, connective tissue, muscle tissue, and nervous tissue are woven together within the body to pro­vide coverings, support, movement, and control, respective­ly (Table 3-1). All tissues produce hormones. For example, skin makes vitamin D, fat makes leptin (to regulate appe­tite), bone makes osteocalcin (to stimulate insulin and tes­tosterone production) and growth factors, and kidneys make erythropoietin.
Epithelial Tissue
Epithelial tissue, or epithelium (EH-pih-THEE-lee-uhm), covers the outside of our bodies, lines cavities and tubes inside our bodies, and forms the glands in the body. Protection, absorption, filtration, excretion, and secretion are functions specific to individual types of epithelia. All epi­thelial tissues share some common characteristics:
• Epithelial cells fit closely together without many gaps, forming epithelial tissue that is a continuous sheet of tightly joined cells.
• The top surface of epithelium is unattached and exposed to an open space (or was at some point dur­ing its development), either the environment or an internal body cavity.
Tissue Type Function Location
Epithelium Lines
Covers Produces secretions
Connective tissue
Muscle tissue
Cardiac Contracts the
Skeletal Moves and
Connects Protects Supports
heart
stabilizes
Skin, organs, glands
Blood, bone, cartilage, fascia, fat, ligament, lymph, tendon
Heart
Attached to skeleton
• The bottom surface of epithelium lies on a base­ment membrane, which is a material secreted by the epithelial cells and has no structure.
• There are no blood vessels in epithelia (they are avas­cular), so they rely on diffusion of nutrients through the basement membrane.
Epithelia are classified according to the arrangement and shape of the cells within the tissue. By arrangement, epithe­lia are classified by the number of layers of cells. Simple epi­thelium is formed with only a single layer of cells. Stratified epithelium has more than one layer of cells in its structure, making it more durable. By cell shape, the classifications include squamous (flat), cuboidal (cube-like), and columnar (column-like). The different types of epithelia are generally identified by their structural layers and cell shape (Fig. 3-8):
• Simple squamous—found in air sacs of the lungs, walls of capillaries, and serous membranes
• Simple cuboidal—in glands and their ducts
• Simple columnar—in mucous membranes and the lining of the digestive tract
• Pseudostratified columnar—in parts of the respira­tory tract
• Stratified squamous—in the mouth, outer portion of skin, and esophagus
• Stratified cuboidal—not very common, but found in the ducts of large glands
• Stratified columnar—not very common, but found in the ducts of large glands
• Transitional—highly modified epithelium found in the lining of the urinary bladder, ureters, and part of the urethra
There is a special type of epithelium that does not have lining or covering functions. Glandular epithelium develops into glands, which produce and secrete fluids that contain special proteins. Exocrine (EK-soh-krihn) glands use ducts to deliver their secretions to the top surface of the epithelium. Sweat and oil glands are examples of exocrine glands that release their secretions outside our bodies. The liver and the pancre­as are exocrine glands that release their secretions inside our bodies. Endocrine (EN-doh-krihn) glands, which also develop from glandular epithelium, are ductless, so their secretions diffuse directly into the bloodstream. The thyroid, adrenal, and pituitary glands are examples of endocrine glands.
Smooth Produces
peristalsis
Nervous tissue
Communication and control
Organs
Brain, spinal cord, nerves
Connective Tissue
Connective tissue serves many different functions and is located throughout the body. It connects one part of the body to another, it provides a gentle support structure to various parts of the body, it protects internal organs, and it
Chapter 3 / Body Systems
Esophagus
(stratified squamous)
65
Stomach
(simple squamous)
Epithelium
Mucosa Submucosa
Muscularis externa
Epithelium
Mucosa
Submucosa
Muscularis externa
Serosa
(pseudostratified columnar)
Trachea
Small intestines
(simple columnar)
Cilia
Epithelium
Mucosa
Submucosa
Tracheal cartilage
Smooth muscle
Blood vessels
Villi
Epithelium
Mucosa Submucosa
Muscularis externa
Serosa
Urinary bladder
(transitional)
Epithelium
Smooth muscle bundles and interstitial connective tissue
Serosa
Figure 3-8. Examples of epithelia.
Palm
(simple cuboidal)
Stratified squamous keratinized epithelium
Sweat glands
Papillary layer of the dermis
66 INTRODUCTION TO MASSAGE THERAPY
serves as a defensive barrier against disease. It is composed of living cells suspended in their own secretion of a non­living structural material called the ground substance. The ground substance is made up of water, protein fibers, and sometimes hard minerals, collectively called the extracellu­lar matrix. The consistency of the matrix can range from fluid to solid, depending on the density of living cells in the matrix, the kinds and quantities of protein fibers incor­porated in the matrix, and the amount of minerals. The matrix can provide a pathway for blood vessels and nerves. Figure 3-9 illustrates connective tissues and their locations in the body.
The protein fibers secreted by the cells and incorpo­rated into the extracellular matrix that provide strength, elasticity, and structural support to varying degrees include collagen (CAHL-uh-jen), elastin (ee-LASS-tin), and reticular (reh-TIK-yoo-lahr) fibers. Collagen fibers are white protein
Figure 3-9. Examples of connective
tissue in different locations in thebody.
Ligaments
fibers that provide strength in structures such as the bones and tendons. Elastin is a yellow protein fiber with an elastic or stretchy quality that allows structures such as the vocal cords and walls of large blood vessels to return to their orig­inal length after being stretched. Reticular fibers are threads of a few collagen fibers that create a delicate, mesh-like web material often found in areolar tissue. The reticular fibers support large numbers of free blood cells in the spleen, lymph nodes, and liver. Figure 3-10 shows the difference between collagen and elastin protein fibers in the extracel­lular matrix of areolar connective tissue.
The density and arrangement of any one or a combination of these protein fibers contribute to the strength and elasticity of a particular tissue. Dense fibers tend to result in stronger, harder connective tissues. The more loosely these fibers are packed in the matrix, the more pliable the tissue. Fiber arrange­ments can be random or aligned. When the fibers are aligned
Tendons
Muscle
Bones
Blood vessels
Adipose tissue
Cartilage
Chapter 3 / Body Systems
67
Collagen fibers
Areolar connective tissue
Figure 3-10. Collagen and elastin fibers in an extracellular matrix.
Elastin fiber
in the same direction, the tissue resembles ropelike cords, as in the tendons and ligaments. Scar tissue has a random arrange­ment and has a patchwork-like quality. Connective tissue can be categorized into four groups: hard, fibrous, soft, and liquid. Figure 3-11 illustrates the four types of connective tissues.
Hard Connective Tissue
The hard connective tissues are very firm and not very pli­able, and some contain hardened minerals that further solid­ify their structure. The two forms of hard connective tissue in our bodies include cartilage and bones.
Cartilage
Cartilage is a form of hard connective tissue that is firm, smooth, and bendable. It is composed of living chondrocytes (KON-droh-sahytz), or cartilage cells, suspended in a non­living extracellular matrix that contains collagen and elastin protein fibers. It functions as a shock absorber that can bear mechanical stress without permanent distortion and reduce friction between moving parts, as in the knee joint. Cartilage can also be used as a material for structural support, as in the outer ear. Cartilage is avascular, which makes it slow to heal after injury. It can only receive nourishment via diffusion from capillaries in the adjacent tissues or from the synovial fluid that bathes and lubricates freely movable joints. While temporary cartilage forms the fetal skeleton and is later ossi­fied and converted to bone, permanent cartilage remains throughout life. The three major types of cartilage are hya­line cartilage, fibrocartilage, and elastic cartilage (Table 3-2).
Adipose tissue
(soft)
Areolar
(soft)
Collagen fiber
Cell
Fat-filled cells
Blood (liquid)
Red blood cells
Channel (for nerves and blood vessels)
Bone cells
Bone (hard)
Collagen bundles
Cells
Muscle cells
Figure 3-11. Examples of the four types of connective tissue: soft, liquid, hard, and fibrous.
Tendon
(fibrous)
Cartilage
(hard)
68 INTRODUCTION TO MASSAGE THERAPY
Cartilage Characteristics Examples
Hyaline Strong, not very flexible Costal cartilage
Hyaline cartilage (costal cartilage)
Fibrocartilage Strongest Intervertebral discs
Elastic Most flexible Outer ear
Fibrocartilage (intervertebral discs)
Elastic cartilage (external ear)
Hyaline cartilage is the most common form of permanent cartilage and provides strength and shock absorption but not much flexibility. It appears white or whitish blue because of its avascularity and the predominance of white collagen protein fibers. It is found where two bones come together and need
some padding, for example, where the ribs contact the sternum and at the growth zones at the ends of long bones. Hyaline car­tilage also provides a structural framework in the walls of large respiratory passages that go from outside the body to the lungs, including the nose, trachea, and bronchi.
Chapter 3 / Body Systems
69
Elastic cartilage has an abundance of elastic fibers, which give it a yellowish color and make it the most flex­ible type of cartilage. It can be bent and return to its nor­mal shape, providing a structural framework for parts of the body that are subjected to higher amounts of movement, such as the external part of the ear, the ear canal, the eusta­chian tube, and the epiglottis.
Fibrocartilage has dense collagen fibers surrounding rows or groups of chondrocytes, making it extremely resilient. Providing a cushion between bones that are only slightly mov­able, fibrocartilage is found between adjacent vertebrae (bones in the spine) and in the sutures between the cranial bones.
Bone
Bone is the other form of hard connective tissue. Calcium and phosphate salts that accompany the dense collagen fibers in the extracellular matrix create the hardness of bone. There are three different kinds of living cells suspended in the matrix of bone: osteoblasts (AHS-tee-oh-blastz), or bone­forming cells; osteocytes (AHS-tee-oh-sahytz), or mature bone cells; and osteoclasts (AHS-tee-oh-klastz), or bone­destroying cells. Figure 3-12 shows the difference between the matrix of bone and the matrix of hyaline cartilage.
Bones are much more than a compilation of proteins and minerals. Their structure is a highly organized series of bundles of osteocytes and blood vessels. Because of its high vascularity, bone heals quickly, relative to other tissues. Bone, which is the main component of the skeletal system, has many functions:
• Bones are the main storage place for calcium and other ions.
• Bones act as a lever system for converting muscle contraction into movement.
• Blood cells are formed inside many bones.
• Bones protect soft tissue structures in the body.
Fibrous Connective Tissue
Fibrous connective tissues, sometimes called dense connective tissues, are found as tendons, ligaments, and scar tissue. Most of the protein fibers in the extracellular matrix are collagen fibers that are all aligned in the same direction, giving the fibrous con­nective tissues a cord-like structure that is strong and flexible.
Tendons connect muscles to bones and, as part of the muscle–tendon (musculotendinous) unit, create skeletal movement. Almost every muscle has at least one tendon attached to it, and some muscles have more than one ten­don. Because the tendons themselves do not actively con­tract or relax, they vary in tension, depending on the activity of the muscles to which they attach. For example, a tendon attached to a muscle that is working against a lot of resis­tance will feel tight and not very pliable, like an elastic band that has been stretched almost to its limit. A tendon attached to a muscle that is relaxed will feel looser, like a rubber band lying on a table. Specialized tendons that are broad and flat called are called aponeuroses (AP-poh-nur-OH-seez). They provide attachment for broad muscles to connect to bone or for one set of muscles to connect toanother.
As a form of fibrous connective tissue, tendons have parallel collagen fibers that are dense and regular. The dense arrangement and poor blood supply make it difficult for the nutrient–waste exchange to occur. Because this exchange occurs mostly through diffusion from the surrounding tis­sues, injured tendons heal slowly.
Ligaments are fibrous connective tissue structures that connect bones to bones at a joint. They stabilize and strengthen the joints of the body that must withstand great mechanical force, such as the knee and the hip. As in tendons, most of the protein fibers are dense, regular, parallel strands of collagen. Ligaments are more flexible than tendons because there are more elastin fibers and the proportion of ground substance to protein is larger. Ligaments remain tight despite movement or various states of contraction and are more
Figure 3-12. Hard connective tissue
matrix: hyaline cartilage and compact bone.
Matrix Chondrocytes Osteocytes
Hyaline cartilage Compact bone
Matrix
70 INTRODUCTION TO MASSAGE THERAPY
difficult to palpate because of their location within joints. Because of the minimal blood supply to the ligaments at their attachment sites, the healing process is very slow.
Scar tissue is a special kind of fibrous connective tissue that forms when tissues are injured. It is unique because, unlike those in tendons and ligaments, the collagen fibers are not arranged in a parallel pattern. Because of the abundance of dense and irregular collagen fibers, scar tissue is strong but not as pliable as normal, healthy tissue. Serving as a replace­ment for other injured tissue, it cannot perform the func­tions of the tissue it replaces, and its blood supply is minimal. Extensive scarring can restrict normal movement, reduce or prevent normal circulation of blood and lymph, and impede or even prevent injured tissue from functioning properly. The structure of scar tissue depends on where the injury occurs, but it usually contains the same components as the original tissue, accompanied by an abundance of extra collagen fibers.
Soft Connective Tissue
Soft connective tissues are also called loose connective tis­sues. They have more living cells and fewer protein fibers in their matrix and are highly vascular, giving them a relatively fast healing rate.
Areolar (ah-REE-oh-lahr) tissue is a form of soft con­nective tissue that is highly vascular, delicate, and somewhat resistant to stress. Phagocytes, living cells that engulf bacte­ria or cellular debris, are present in the matrix, accompanied by few collagen and elastin fibers. Found just below the skin, in membranes around blood and lymph vessels, around organs, and between muscles, areolar tissue cushions and protects the structures it surrounds.
Adipose tissue, commonly called fat, is basically areolar tissue with adipose cells suspended in the matrix. Adipose cells can synthesize fat and store it as a large droplet of oil. When the body needs a source of energy, it can use fat released by adipose cells. Besides its function as a source of energy, adipose tissue acts as a thermal insulator. Heat is not conducted well through the fat, which means that if there are different temper­atures on either side of the adipose tissue, those temperatures will be maintained. Adipose tissue also provides padding and protection for organs in its locations just beneath the skin in the superficial fascia, around organs, between muscles, in the mar­row of the long bone shafts, and in the breasts and hips.
Liquid Connective Tissue
Blood and lymph are sometimes called liquid connective tissues because they have living cells suspended in a nonliv­ing matrix and they “connect” different parts of the body. Technically, however, neither blood nor lymph has an extra­cellular matrix that is secreted by the living cells. Moreover, blood has protein fibers present in the matrix only during the process of blood clotting. Blood flows through the blood ves­sels of the cardiovascular system, and lymph flows through the lymphatic vessels in the lymphatic system. Blood and
lymph are described in more detail in the sections on the car­diovascular system and the lymphatic system, respectively.
Muscle Tissue
Tissues are a group of cells with similar structure and func­tion. Muscle tissue is a group of muscle cells that are grouped together with blood vessels and packaged with connective tissue in a specific organization, more commonly called a muscle . These cells have an elongated shape and are some­times referred to as muscle fibers. Muscle cells have the special ability to contract and relax, resulting in their primary function of creating movement. Skeletal, cardiac, and smooth muscle tissues are the three types of muscle tissue that have slightly different characteristics and arrangements. Some have striations (strahy-AY-shunz), which are microscopic structur­al features that look like stripes. Some muscle cells contain more than one nucleus, and some muscle cells form branch­ing networks of cells. The control mechanism for muscle cells can also differ. Some are involuntary, meaning that they contract without our conscious effort, and others are volun­tary, which means that we have to consciously make an effort to contract the muscle to create movement. Table 3-3 char­acterizes the different types of muscle tissue. This section of the body systems chapter briefly introduces and compares the different kinds of muscle tissue. There is a comprehensive discussion of skeletal muscle tissue below in this chapter.
Skeletal Muscle
Skeletal muscle is tissue that attaches to the skeleton. The cells are long and cylindrical with multiple nuclei and heavy striations. Skeletal muscle tissue is under voluntary control, meaning that we consciously make skeletal muscles contract to move our bodies. When actively contracted, skeletal mus­cles are shortened and the muscles cells are closer together. As a result, blood vessels are constricted, and the delivery of nutrients and elimination of cellular metabolic waste is limited. Healthy muscles at their normal resting length have more space between the cells and the exchange of oxygen, nutrients, and waste is more efficient. Skeletal muscle tissue is responsible for producing body movement and holding our bodies up against the force of gravity. Simply, gravity is the force that pulls us to the earth, and except when we are lying down, we use skeletal muscles to hold ourselves upright.
Massage deals with movement, restriction of move­ment, and restoration of health to the skeletal muscle sys­tem. Understanding skeletal muscle tissue and how it functions
is fundamental to massage.
(tense) skeletal muscles by using the help of the nervous sys­tem to stop triggering muscles to contract. Once the muscles stop receiving signals from the nervous system to contract, they can relax, and then other massage techniques can help return skeletal muscles to their normal resting lengths. Using massage to return skeletal muscles to their normal
Massage can relax hypertonic