CST 2015 / ErbB_HER
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CELL SIGNALING TECHNOLOGY |
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ErbB/HER Signaling
H4ER4/ErbB |
TACE |
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γ-Sec |
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PSD95 |
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BDP1 |
Gab1
Shc
Cell
Memo Cycle
Cell
Migration
Cell
Adhesion
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NRG2 |
NRG3 |
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HB-EGF |
TGF-α |
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NRG1 |
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EGF |
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EGF |
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NRG4 |
NRG4 |
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AREG |
EPG |
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GFR/ErbB1EER2/ErbB2H |
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βCEL. |
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H2R2/ErbBE |
H44/ErbBRE |
2H2/ErbBRE4H4/ErbBRE |
R3/ErbB3EH R2/ErbB2EH |
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EGFR/ErbB1 |
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EGFR/ErbB1 |
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MIG6 |
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Dok |
GEP100 |
TSAd |
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Shc |
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GAB2 |
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CXCR4 |
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TNS3 |
TNS4 |
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GRB2 |
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SHP-2 |
Calcineurin |
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GRB2 |
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Invasion |
PI3K |
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ARF6 |
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Metastasis |
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Vav1 |
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Cbl |
AIP4 |
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Yes |
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Increase |
FAK |
c-Cbl |
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Tumor |
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Cell Motility |
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Rac1 |
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Crk |
Endosome- |
Ub |
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Invasion |
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p130 Cas |
Nck1 |
Spry |
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Akt |
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mediated |
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SOS |
Syk |
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Recycling |
HRS |
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of EGFR |
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Src |
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c-Abl |
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mTOR |
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PAK1 |
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Muc1 |
Caveolin |
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Lysosome- |
Ras |
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PLC |
Jak |
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mediated |
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Paxillin |
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Degradation |
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β-Cat |
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of EGFR |
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Calmodulin |
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p70S6K |
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MEKK1 |
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Raf |
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MEK2/3 |
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E-cadherin |
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cdc42 |
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JNK |
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MEK |
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MEK5 |
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HER2/ICD |
Importin β1 |
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Protein |
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Nup358 |
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Survival |
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Apoptosis |
Synthesis |
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Proliferation |
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Cellular Proliferation, |
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Cytoplasm |
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DNA Repair |
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Nucleus |
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cdc2 |
PCNA |
DNA-PK |
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CaMK |
PKC |
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Cell |
Cytoskeletal |
MAPK |
ERK5 |
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Stat |
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Motility |
Regulation |
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MEF2 |
ICD HER4
Stat
ICD
HER4
TAB2
N-CoR
1 - EGFR/ErbB
E2F
1 - EGFR/ErbB
Stat CREB |
Jun Fos |
Elk |
Stat MEF2 |
Cell Proliferation, Inflammation, |
Cell Growth/Differentiation, |
Growth Differentiation |
Genome Instability, Tumor Progression |
Cell Shape, Chemotaxis |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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