CST 2015 / Hedgehog
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CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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Hedgehog Signaling
Skn
Mammalian |
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HhN |
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Ligands: |
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Ihh |
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On-State |
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Dhh |
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Smo |
COS2/Kif7 |
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Shh |
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Gαi |
SuFu |
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Gli 1/2/3 |
Primary |
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HhN |
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Cilium |
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β-Arrestin |
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CDO/BOC |
PTCH1 |
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Microtubules |
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(Ihog/boi) |
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Gli |
-Act Active |
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KCTD11 |
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Cyclin D, Cyclin E, Myc |
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Gli 1/2-Act |
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Gli1, Patched, HIP |
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Nucleus |
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Cytoplasm |
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Pathway Diagram Keys
Hh
ER/Golgi
HhN
Hh Secreting Cell
Dispatched
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Off-State |
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COS2/Kif7 |
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PTCH1 |
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SuFu |
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Gli 1/2/3 |
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Primary |
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Cilium |
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SuFu |
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Gli 1/2/3 |
PKA |
CDO/BOC |
Microtubules |
CK1 |
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(Ihog/boi) |
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β−TrCP |
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GSK-3β |
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Gli 1/2/3 |
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Smo |
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Proteasome |
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Gli 1/2 |
Gli 3-R |
Repressor |
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no transcription of |
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Gli 3-R |
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target genes |
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Nucleus |
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Cytoplasm |
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Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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