CST 2015 / esc_pluripotency
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CELL SIGNALING TECHNOLOGY |
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ESC Pluripotency and Differentiation
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TGF-β/Activin/Nodal |
FGFR |
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Wnt |
IGF-IR |
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LRP |
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Frizzled |
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SARA |
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Ras/ |
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Gαq/o |
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Smad2/3 |
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Raf |
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PI3K |
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PP2A |
BMP
Notch
Smad1/5/8
γ−Secretase
MEK1/2 |
APC Axin GSK-3 |
Smad2/3 |
β-catenin
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Smad1/5/8 |
Smad4 |
NICD |
Akt |
Erk1/2 |
β-catenin |
Smad2/3 Smad4 |
Smad1/5/8 Smad4 |
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Smad2/3 |
Smad1/5/8 |
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Cytoplasm
Nucleus
Erk1/2 |
β-catenin |
Smad2/3 |
Smad1/5/8 |
NICD |
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Gene Expression |
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Gene Expression |
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Oct-4 |
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Gene Expression |
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Sox2 Nanog |
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Pluripotency and Self Renewal |
Differentiation |
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hESC markers: |
Endoderm |
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Oct-4 |
SSEA3/4 |
Mesoderm |
Sox2 |
TRA-1-60 |
Ectoderm |
Nanog |
TRA-1-81 |
Primordial Germ Cells |
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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