CST 2015 / Hippo_Signaling
.pdfCELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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Hippo Signaling
brC |
44DC |
T4AF
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Tight Junction
Adherens Junction
ZO-2 YAP/TAZ |
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AMOT |
FRMD MerKIBRA |
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YAP/TAZ |
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RASSF |
TAO-1 |
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PP2A |
α-catenin |
SAV1Mst1/2 |
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14-3-3 |
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YAP |
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Ajuba
MOB1 F-actin
AMOT LATS1/2
CK1
14-3-3
YAP/TAZ YAP
β-TrCP
WBP2
YAP/TAZ
TEAD1-4 Smad p73
ITCH
PP1
ASPP2
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Transcription
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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