CST 2015 / Insulin_Receptor
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CELL SIGNALING TECHNOLOGY |
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Insulin Receptor Signaling |
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Insulin Receptor |
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Glucose |
SNARE |
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TNF |
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Complex |
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GLUT4 |
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p85 |
Gab1 |
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TNFR1 |
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CAP |
Cbl APS |
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IRS |
Shc |
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Synip |
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PIP3 |
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FlotillinCav PTEN |
PI3K |
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SOCS3 |
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p110 |
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GLUT4 |
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Crkll |
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SHIP |
Akt2 SHP-2 |
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GRB2 |
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PTP1B |
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EHD1 |
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Nck |
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Translocation |
TC10 C3G |
EHBP1 |
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IRS-1 |
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Crkll |
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CIP4/2 |
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PKCλ/ζ |
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Fyn |
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SOS |
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PDK1 |
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Rac1 |
mTORC2 |
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PKCθ |
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Jnk |
GRB10 |
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IKK |
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GLUT4 |
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PKCλ/ζ |
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Ras |
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vesicle |
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PP2A |
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FFA |
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14-3-3 |
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LKB1 |
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NO |
iNOS |
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GLUT4 |
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AS160 |
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Akt2 |
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Exocytosis |
14-3-3TBC1D1 |
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AMPK |
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ROS |
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c-Raf |
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PDK1 |
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TSC2 |
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PDE3B |
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Bad |
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TSC1 |
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SIK2 |
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GSK-3 |
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PRAS40 |
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Rheb |
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[cAMP] |
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MEK1/2 |
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SGK |
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Apoptosis |
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PKA CBP/p300 |
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SREBP-1 |
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mTORC1 |
p70 |
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Torc2 |
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PP1 |
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GS |
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4E-BP1 |
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Erk1/2 |
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ATP-citrate |
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S6K |
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Degradation |
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ENaC |
Glycogen |
lyase |
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eIF4E |
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HSL |
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Synthesis |
Fatty Acid |
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Protein |
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Sodium |
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Lipolysis |
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Synthesis |
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Synthesis |
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Transport |
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Cytoplasm
SGK
Nucleus
FoxO3A FoxO4
Apoptosis 
Transcription
Akt2 |
Erk1/2 |
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Fatty Acid |
Disruption of |
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Synthesis |
CBP/Torc2/CREB |
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FoxO1 |
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Complex |
Erk1/2 |
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SREBP-1 LXRα USF |
Gluconeogenesis |
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mTORC1 |
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mTORC2 |
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Growth |
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GβL |
Raptor |
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Sin1 PRR5 |
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mTOR |
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Rictor |
GβL |
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DEPTOR |
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mTORDEPTOR |
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Pathway Diagram Keys |
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Kinase |
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Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
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GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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© 2010 – 2014 Cell Signaling Technology, Inc.