CST 2015 / Histone_Methylation
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CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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Histone Lysine Methylation
Transcriptionally Inactive
Chromatin
Me Me
Me |
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Me |
SET8, |
Pericentric Heterochromatin |
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H4K20meSUV420H |
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PHF8 |
SUV |
SUV |
SUV |
SUV |
39h |
39h |
39h |
39h |
HP1 |
HP1 |
HP1 |
HP1 |
Me |
Me |
Me |
Me |
SUV39H, G9a,
ESET
H3K9me
LSD1, JMJD1,
JMJD2
Pericentric Heterochromatin |
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Inactive X Chromosome |
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Rb-Mediated Repression |
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Ezh1/2 |
JMJD3 |
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H3K27me |
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PRC1 |
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PRC1 |
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PRC1 |
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PRC1 |
UTX, |
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PC |
Me |
PC |
Me |
PC |
Me |
PC |
Me |
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Transcriptionally Active
Chromatin
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NURF |
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NURF |
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BPTF |
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BPTF |
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Me |
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Me |
Me |
Me |
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-4, |
SET1A/B, |
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SET7/9, |
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MLL1 |
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JARID1, |
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H3K4me |
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SETD1B, |
JHDM1B |
Transcription Initiation |
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LSD1, |
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NSD1, SET2, SMYD2 |
Me |
Me |
Me |
Me |
H3K36me |
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JMJD2, JHDM1A, |
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JHDM1B |
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H3K79me?? |
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DOT1L |
Transcription Elongation |
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Me |
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Me |
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Me |
Me |
Anti-Silencing
Inactive X Chromosome
Hox Gene Repression
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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