CST 2015 / Cell_Cycle_G2M_DNA
.pdf
CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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Cell Cycle Control:
G2/M DNA Damage Checkpoint
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IR |
UV |
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Critically Short |
FANCD2 |
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Telomeres |
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POT1 TRF2 |
DNA |
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Repair |
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DNA Repair |
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Rad50 NBS1 |
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Mre11 |
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ATM/ |
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(MRN) |
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HIPK2 |
DNA-PK |
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ATR |
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Caffeine |
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BRCA1 |
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BRCA1 |
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MDM4 |
WIP1 |
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c-Abl |
Rad51 |
Nuclear Export, |
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MDM2 |
p53 |
Chk2 |
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Rad52 |
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Ubiquitination |
Chk1 |
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Nucleolar |
p19Arf |
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cdc25A |
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14-3-3 |
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Sequestration |
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or |
MDM2 |
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p53 Stabilization |
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p300/ |
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cdc25A/C |
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TRIP12 |
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p53 |
cdc25 |
Nuclear Exclusion |
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PCAF |
cdc25A/B |
Ubiquitination |
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WIP1 |
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AurA Bora |
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PLK1 |
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TopoII BRCA1 14-3-3σ Reprimo |
GADD45 |
p21Cip1 CDK7 |
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SCF |
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Myt1 |
p90RSK |
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Nuclear |
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SCF |
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Exclusion |
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cdc2 |
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Wee1 |
Ubiquitination |
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E |
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S |
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A |
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H |
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P |
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- |
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2 |
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G |
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Cyclin B
M-PH
ASE
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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