CST 2015 / Autophagy
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CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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Autophagy Signaling
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PI3K-I / Akt |
MAPK / Erk1/2 |
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Signaling |
Signaling |
AMP: |
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AMPK |
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p53 / Genotoxic |
ATP |
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Stress |
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Amino |
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Acids |
GβL |
mTOR Raptor |
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PRAS40 |
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p150 |
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ULK1 |
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PI3 Kinase |
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Class III |
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Atg13 FIP200 |
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Bcl-2 |
Beclin-1 |
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Atg14 |
Membrane |
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Apoptosis |
Rubicon |
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Nucleation |
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Phagophore |
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Sequestration |
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SQSTM1/p62 |
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Atg16L1 |
Atg12 |
Atg5 |
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+ NBR1 + LC3-II |
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Cytoplasmic |
ALFY |
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Atg16L1 |
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Contents |
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Atg5 |
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Atg10 |
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Atg3 |
PE |
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Atg7 |
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Atg7 |
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Autophagosome
LAMP1
LAMP2
Lysosome
Fusion
Autophagolysosome
Atg12 |
LC3-I |
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Lysosome |
Atg4
LC3
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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