CST 2015 / Death_Receptor
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CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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Death Receptor Signaling
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TNF-α |
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FasL |
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TNF-R1 |
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Fas/ |
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CD95 |
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TRADD |
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FADD |
TRAF2 |
RIP1 |
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Daxx |
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cIAP1/2 |
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CYLD |
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ASK1 |
RIP |
Casp-8, -10 |
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BID |
FLIP |
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MKK1 |
tBID |
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Complex |
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Cyto c |
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IIb |
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MLKL |
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JNR |
Bcl-2 |
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Casp-8 |
RIP1 |
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FADD |
RIP3 |
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Bcl-2 |
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TNF-α |
APO-3L/ |
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TWEAK |
APO-2L/ |
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TRAIL |
TNF-R2 |
DR3 |
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APO-3 |
DR4/5 |
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TRAF2 |
TRAF1 |
RIP |
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cIAP1/2 |
TRADD |
TRADD |
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IKKα/β/γ |
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TRAF3 |
FADD |
FADD |
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IκB
Complex NF-κB
IIa
Casp-8
FADD RIP1
TRAF2 TRAF1 cIAP1/2
Casp-8,-10
NIK
IKKα
Casp-9 |
Apaf1 |
Smac |
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IκB |
NF-κB |
RelB |
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p100 |
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XIAP |
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Active |
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XIAP |
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Caspase-8 |
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Processing |
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Casp-6 |
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Necroptosis |
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Casp-3 |
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Casp-7 |
NF-κB |
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p65/ |
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RelA |
p50 |
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Acinus |
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p52 RelB |
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Lamin A |
Actin GAS2 α-Fodrin ROCK1 DFF45 |
PARP |
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Pro-Apoptotic |
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DFF40 |
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Pro-Survival |
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Cell Shrinkage |
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DNA |
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Chromatin |
Transcription |
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Membrane Blebbing |
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Fragmentation Condensation |
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Apoptosis |
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Survival |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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© 2002 – 2014 Cell Signaling Technology, Inc.