CST 2015 / B_Cell_Antigen
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CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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B Cell Receptor Signaling
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BCR |
Ag |
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mIg |
α/β α/β |
mIg |
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CD19 |
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Lyn |
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CD22 |
SHP-1 |
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Gab |
BCAP |
PI3K |
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Shc |
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SHP-2 |
PIP3 |
GRB2 |
FcγRIIB1 |
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Lipid |
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Lyn |
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p85 p110 |
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Ezrin |
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CD19 |
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Raft |
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Syk |
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SHIP |
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BCR |
Aggregation |
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SHP-1 PIR-B |
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CD45 |
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RhoA |
PTEN |
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Dok-3 |
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Internalization |
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PI(4,5)P2 |
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clathrin |
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SHP-2 |
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Ca2+ |
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Bam32 |
Cbp/PAG |
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Cbl |
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Btk |
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IP3R |
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Csk |
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Bam32 |
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STIM1 |
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PLCγ2 |
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Intracellular |
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BLNK GRB2 |
LAB |
DAG |
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Akt |
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Ca2+ Store |
Ca2+ |
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LAB |
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CIN85 |
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IP3 |
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GRB2 Vav |
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SOS |
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Rac/ |
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PKC |
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CD19 |
HS1 |
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Ras |
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cdc42 |
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PIP3 |
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Pyk2 |
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GRP |
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Cytoskeletal |
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DAG |
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Ras |
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CARMA1 |
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Ras |
TAK1 |
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Rearrangements and |
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Rac |
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Integrin Activation |
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GAP |
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Bcl10 |
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RapL |
Rap |
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c-Raf |
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MALT1 |
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mTOR |
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GSK-3 |
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Riam |
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Dok-1 |
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CaM |
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MEKKs |
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Cofilin |
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FcγRIIB1 |
IKK |
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DAG |
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CD19 |
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MEK1/2 |
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Calcineurin |
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p70 |
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MKK3/4/6 |
MKK4/7 |
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PKC |
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Ca2+ |
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IκB |
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S6K |
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CD40 |
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Erk1/2 |
IκB |
NF-κB |
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NFAT |
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Protein |
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p38 |
JNK1/2 |
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Proteasomal |
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Synthesis |
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Cytoplasm |
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Degradation |
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Ca2+
Oai1rChannel
CACR
Glucose
Uptake
Glycolysis
ATP
Generation
Nucleus
p38 |
JNK |
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Erk1/2 |
NF-κB |
CaMK |
Akt |
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FoxO |
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MEF2C CREB |
ATF-2 Jun |
Bcl-6 Egr-1 Elk-1 Bcl-xL Bfl-1 Oct-2 |
Ets-1 |
NFAT |
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Transcription |
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Transcription |
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Growth Arrest, |
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Apoptosis |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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