CST 2015 / Cell_Cycle_G1S
.pdf
CELL SIGNALING TECHNOLOGY |
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www.cellsignal.com |
Cell Cycle Control: G1/S Checkpoint |
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Growth Factor |
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Receptor Activation |
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Akt |
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DNA |
Replicative |
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TGF-β |
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Damage |
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Senescence |
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FoxO1/3 |
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Differentiation |
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ATM/ |
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ATR |
Hormones |
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Smad3 |
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BMI1 |
Myc |
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Smad4 |
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p53 |
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Ultra Violet |
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Replicative |
Stress Response |
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Senescence |
p19 INK4D p18 INK4C p16 INK4A |
p15 INK4B |
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p21 Cip1 |
Chk1/2 |
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Growth |
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Myc |
p27 Kip1 |
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Ubiquitination |
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Factor |
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Withdrawal |
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Myc |
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cdc25A |
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Myc |
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GSK-3β |
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SCF |
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CDK4/6
Ubiquitination 
Cyclin D
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E |
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S |
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A |
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H |
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P |
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- |
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1 |
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G |
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CDK2
R |
Cyclin E |
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S- |
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P |
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H |
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A |
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S |
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E |
Ubiquitination
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Suv39H1 |
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E2F/DP Target Genes: |
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Abl Rb HDAC |
Rb |
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FoxO1 |
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Bim |
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Cyclin E/A, E2F-1/2/3, |
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E2F |
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E2F |
cdc2, c-Myc, p107, |
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FasL |
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RanGAP, TK, DHFR, |
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DBE |
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Apoptosis |
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DP-1 |
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DP-1 |
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TRAIL |
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OFF |
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ON |
PCNA, H2A, etc. |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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