CST 2015 / MAPK_ERK_Growth
.pdf
CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
MAPK/Erk in Growth and Differentiation |
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RTKs |
Integrins |
Ion Channels |
RTKs |
[Ca2+] |
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[Ca2+]
MEK1
LAMTOR2
MP1
Erk1
Late Endosome
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FRS2 |
GRB2 |
SOS |
Ras |
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PLCγ |
Shc IRS |
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Spry |
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Src |
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PYK2 |
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Spred |
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SOS |
GRB2 |
CAS |
Tal |
Rap1 |
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RACK1 |
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PI3K |
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Fyn |
Pax FAK |
C3G |
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EPAC |
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PAK |
Rac |
[cAMP] |
Raptor |
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c-Raf |
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PKA |
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AMPK |
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PKC |
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c-Raf B-Raf |
B-Raf |
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LKB1 |
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Heterodimer |
14-3-3 |
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Tpl2/Cot1 |
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PD98059 |
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U0126 |
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IMP |
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AZD6244 |
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Ion Channels, |
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PP1/ |
FMK |
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C-TAK1 |
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KSR |
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PP2At |
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Receptors |
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SL0101 |
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cPLA2 |
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1/2 |
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SOS |
BI-D1870 |
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MEK1/2 |
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Bim |
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Translation |
MNK1/2 |
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Erk1/2 |
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p90RSK |
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Control |
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CRK
mTOR Signaling
rpS6 TCPβ eIF4B IκBα
Filamin A
eEF2K GSK-3 DAPK METTL1 BAD nNos
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Erk1/2 p90RSK |
MKP-3 |
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TSC2 |
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Cell Adhesion |
PEA-15 |
Cytoplasmic Anchoring |
WAVE-2 |
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PLD1 |
Ca+2-regulated |
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Migration |
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Exocytosis |
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Cytoplasm
Nucleus
MKP-1/2
cdc25 |
PPARγ |
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Erk1/2 |
MSK1/2 |
p27 KIP1 |
p90RSK |
BUB1 |
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ER |
Ets |
Elk-1 |
TIF1A FoxO3 CREB |
ATF1 |
ER81 |
SRF |
c-Fos |
ERα |
Nur77 |
MITF |
C/EBPβ |
Stat1/3 |
c-Myc/ |
Pax6 |
c-Fos |
Histone |
HMGN1 |
ETV1 |
TIF1A |
ATF4 |
Myt1 |
Mad1 |
YB1 |
N-Myc |
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H3 |
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UBF |
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Transcription
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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