CST 2015 / Notch
.pdf
CELL SIGNALING TECHNOLOGY |
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Notch Signaling
Endosome
Signal
Sending
Cell
Inactive
Ligand
Delta
Jagged
Extracellular
Space Notch
ub
Active
Ligand
Neur or Mib
ub
Delta
Jagged
Ligand
Repositioning
ub
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ADAM/ |
Notch |
TACE |
Activated
Receptor
Epsin
ub
Ligand-receptor
Internalization
Nicastrin
Presenilin
APH-1
PEN-2
TM
γ
-
Secretase
Complex 
Signal |
Deltex |
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NEDD4 |
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Receiving |
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Cell |
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Fringe
Golgi
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Recycling |
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Endosome |
ub |
NUMB |
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α-Adaptin |
S2 Cleavage
NICD 
S3 Cleavage
Ubiquitin
Degradation
FBX7
S1 Cleavage
Lysosomal
Degradation
O-Fut
ER
Cytoplasm
Nucleus
CtBP1 CIR HDAC |
KDM5A |
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HAT |
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SMRT SHARP |
KDM5A |
MAML |
Notch Target Genes |
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CSL SKIP |
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CSL |
SKIP |
HES Family |
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Myc |
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p21 |
Inactive |
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Active |
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Cyclin D3 |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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