CST 2015 / poster-gprotein-signaling-pathway
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G-Protein Coupled Receptor
Signaling: Overview
Examples |
M1, H1, |
GPR55, SDF-1, |
β1-Adrenergic R |
CXCR4, |
VEGFR, PDGFR, |
V2R, OXTR, |
PAR, S1P |
Wnt Ligand/Frizzled |
GABA-B, LPA |
EGFR |
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AT1R, PAR |
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Transactivation |
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AllGPCRs
β-Arrestin
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GRK |
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Gα |
β,γ |
Gα12/13 β,γ |
Gαs β,γ |
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GDP |
GDP |
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q |
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GDP |
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Gαi
GDP
β,γ
MMPs
RTK
RhoA |
PI3K Src |
Gαq |
β,γ |
Gα12/13 |
β,γ |
Gαs |
β,γ |
Gαi |
β,γ |
Src |
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GTP |
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GTP |
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GTP |
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GTP |
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Ion |
PI3K |
Stat3 |
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Ras |
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AC |
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Channels |
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Akt |
PLCβ |
PKC |
Rac |
RhoA |
Axin |
CDC42 |
PI3K PLCβ |
Ras |
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β-Arrestin |
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[cAMP] |
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CDC42 |
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Raf |
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PAK |
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AP2 |
clathrin |
IP3 |
DAG |
ROCK LATS1/2 |
GSK-3β |
PKA |
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Akt |
Raf |
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Ca2+ |
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SOS |
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MLK |
WASP |
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Erk |
PKC |
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PAK |
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GSK-3 Erk |
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Receptor |
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JNK |
p38 |
β-catenin |
CREB |
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Ras |
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Glycogen and |
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Internalization |
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Actin |
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Fatty Acid |
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p90RSK |
JNK |
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Remodeling |
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LATS1/2 |
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Synthesis |
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Raf |
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mTOR IKK |
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Bad |
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Survival |
Protein |
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Bad |
Bcl-2 |
p53 |
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YAP/TAZ |
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Synthesis |
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Inactive |
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NF-κB |
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Bcl-xL |
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Erk |
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YAP/TAZ |
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c-Myc p53 |
c-Fos |
c-Jun YAP/TAZ |
CREB NF-κB |
Erk |
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N
u
c 
l 
e 
u
s
Pathway Diagram Key
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Direct Stimulatory |
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Multistep Inhibitory |
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Separation of Subunits |
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Transcriptional Inhibitory |
Transcription Factor |
pro-apoptotic |
G-protein |
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Modification |
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Modification |
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or Cleavage Products |
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Modification |
Caspase |
pro-survival |
Acetylase |
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Direct Inhibitory |
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Tentative Stimulatory |
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Joining of Subunits |
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Modification |
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Modification |
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Translocation |
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Kinase |
Receptor |
GAP/GEF |
Deacetylase |
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Multistep Stimulatory |
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Tentative Inhibitory |
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Transcriptional |
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Phosphatase |
Enzyme |
GTPase |
Ribosomal subunit |
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Modification |
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Modification |
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Stimulatory Modification |
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Select Reviews |
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This pathway diagram has been assembled by key opinion leaders in the field of G-Protein Coupled Receptor Signaling in collaboration with Cell Signaling Technology (CST) scientists. CST Pathways are reviewed and updated frequently to provide succinct and current overviews of the subject area. We would like to thank Dr. Jonathan Violin, Trevena Inc., King of Prussia, PA for reviewing this diagram.
Entschladen, F., Zänker, K.S., and Powe, D.G. (2011) Cell Cycle 10, 1086−1091. | Audet, M. and Bouvier, M. (2012) Cell 151, 14−23. | Lappano, R. and Maggiolini, M. (2012) Acta. Pharmacol. Sin. 33, 351−362. | O’Havre, M., Degese, M.S., and Gutkind, J.S. (2014) Curr. Opin. Cell Biol. 27C, 126−135. | Lappano, R. and Maggiolini, M. (2011) Nat. Rev. Drug Discov. 10, 47−60. | Yu, F.X. and Guan, K.L. (2013) Genes Dev. 27, 355−371. | Smrcka, A.V. (2008) Cell. Mol. Life Sci. 65, 2191−2214. | Kahn, S.M., Sleno, R., Gora, S., Zylbergold, P., Laverdure, J.P., Labbé, J.C., Miller, G.J., and Hérbert, T.E. (2013) Pharmacol. Rev. 65, 545–577. | Shukla, A.K., Xiao, K., and Lefkowitz, R.J. (2011) Trends Biochem. Sci. 36, 457−469. | Raiagopal, S., Raiagopal, K., and Lefkowitz, R.J. (2010) Nat. Rev. Drug Discov. 9, 373−386.
© 2014 Cell Signaling Technology, Inc. Cell Signaling Technology® and CST™ are trademarks of Cell Signaling Technology, Inc.
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14PSTREFMNONE0210ENG_00