CST 2015 / Nuclear_Receptor
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www.cellsignal.com |
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Nuclear Receptor Signaling
Type I Steroid Receptors
SBP
Pl |
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M |
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NR
HSP90
Homodimerization |
Nu |
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cl |
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e |
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NR
HSP90 |
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SRC1/2 |
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PRMT/ |
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CARM |
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NR NR |
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CBP/ |
PCAF RNA |
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p300 |
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Transcriptional |
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TBP |
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TFIIB POLII |
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Activation |
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HRE |
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TATA |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
Phosphatase |
pro-apoptotic |
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Acetylase |
Transcription Factor |
pro-survival |
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Deacetylase |
Caspase |
GAP/GEF |
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Ribosomal subunit |
Receptor |
GTPase |
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Direct Stimulatory |
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Modification |
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Type II Non-steroid Receptors
Ligand
Pl |
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as |
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m |
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M |
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m |
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br |
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a |
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pl |
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m |
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N |
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u |
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cl |
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Heterodimerization |
SRC1/2 |
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PRMT/ |
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RXR NR |
CBP/ |
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CARM |
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PCAF |
RNA |
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p300 |
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Transcriptional |
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TBP |
TFIIB POLII |
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Activation |
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HRE |
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NcoR1 |
HDAC |
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NRRXRComplex |
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SMRT |
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No Ligand
Transcriptional Repression
Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Modification |
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Tentative Stimulatory |
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Modification |
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© 2012 – 2014 Cell Signaling Technology, Inc.