CST 2015 / MAPK_G_Protein
.pdf
CELL SIGNALING TECHNOLOGY |
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G Protein-coupled Receptors
Signaling to MAPK/Erk
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RTKs |
Gi-Coupled |
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Receptor |
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MP |
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Giβγ |
PLCβ |
Src GRB2 |
β-Arrestin GRK2 |
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Dynamin |
Src |
PI3Kγ |
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PKC |
Receptor Src-like
Internalization
RasGEF
SOS
Integrins |
Gq-Coupled |
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Receptor |
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Gs-Coupled |
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Receptor |
Src |
FAK |
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Gαq |
AC |
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PLCβ |
Gαs |
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PYK2 |
RACK1 |
GTP |
GTP |
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IP3 |
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RGS |
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PKC |
[Ca2+] |
RGS |
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CaMKII,-IV |
[cAMP] |
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Ras |
Ras |
Ras |
Syn |
EPAC PKA |
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GAP |
GRP |
GRF |
GAP |
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endosome |
Src |
c-Raf |
H+ |
β-Arrestin1 MEK |
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Erk |
JNK3 |
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IMP |
Focal Adhesions |
C-TAK1 |
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Catecholamines |
TH |
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Erk1/2 p90RSK |
p90RSK |
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PEA-15 |
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Cytoplasm |
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Nucleus |
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p90RSK |
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Ras |
c-Raf |
B-Raf |
Rap1 |
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c-Raf |
B-Raf |
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Heterodimer |
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MEK1/2 |
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MKP-3 |
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KSR |
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cPLA2 |
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Synapsins |
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Erk1/2 |
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cdc25 |
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Erk1/2 FoxO3 MSK1/2 MAPKAPK2
Pathway Diagram Keys |
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Transcription |
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Tumorigenesis |
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Progression |
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of Cell Cycle |
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Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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