CST 2015 / MAPK_p38
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CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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Signaling Pathways Activating
p38 MAP Kinase
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DNA Damage, |
Inflammatory Cytokines, FasL |
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TGF-β |
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Oxidative Stress, UV |
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GPCR |
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Gαo |
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TRADD TRAF2 |
RIP Daxx |
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MEKK1-4 |
MLK2/3 |
ASK1/2 |
TAB1 |
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TAO1/2/3 |
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DLK |
TAK1 |
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MKK3/6 |
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MKK4 |
Apoptosis |
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Endocytic |
EEA1 |
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SB203580 |
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Trafficking |
Rho-GDI |
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p38 MAPK |
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eEF2K |
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PRAK |
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HSP27 |
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Translation |
MNK1/2 |
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MAPKAPK-3 |
Cytokine-induced |
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mRNA stability |
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cPLA2 |
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Tau |
p90RSK |
MAPKAPK-2 |
TNF-α biosynthesis |
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Cytoplasm |
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Nucleus |
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p38 MAPK |
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MAPKAPK-3 |
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PRAK |
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MAPKAPK-2 |
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CREB NF-κB |
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MSK1/2 |
p65 |
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Pax6 |
p53 |
Stat1 |
Max |
Myc |
Elk-1 CHOP MEF2 |
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ATF-2 ETS1 |
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ATF1 |
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RARα HMGN1 |
Histone H3 ER81 |
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Transcription |
Cytokine Production, |
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Apoptosis, etc. |
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Pathway Diagram Keys |
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Kinase |
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Enzyme |
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G-protein |
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Direct Inhibitory |
Tentative Inhibitory |
Translocation |
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Phosphatase |
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pro-apoptotic |
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Acetylase |
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Modification |
Modification |
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Transcriptional |
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Multistep Stimulatory |
Separation of Subunits |
Stimulatory Modification |
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Transcription Factor |
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pro-survival |
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Deacetylase |
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Modification |
or Cleavage Products |
Transcriptional |
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Caspase |
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GAP/GEF |
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Ribosomal subunit |
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Multistep Inhibitory |
Joining of Subunits |
Inhibitory Modification |
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Modification |
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Receptor |
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GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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