CST 2015 / Jak_Stat_IL_6
.pdf
CELL SIGNALING TECHNOLOGY |
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Jak/Stat Signaling: IL-6 Receptor Family |
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IL-6 |
EGF |
p120 ras-GAP
E-Ras
Ras
Raf
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gp130 |
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Shc GRB2 |
SHP-2 |
Jak |
SOCS3 |
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Jak |
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Stat3 |
Stat3 |
PI3K |
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SHP-1 |
EGFR |
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SOCS
Src
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PI3K |
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MEK |
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Renewal |
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of ES Cells |
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Akt |
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Stat |
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Erk |
Mcl-1 |
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Akt |
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Tumor-like |
Erk |
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Crosstalk |
Properties |
mTOR |
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Apoptosis |
Tumor Cells |
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of ES Cells |
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Cytoplasm |
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Nucleus
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Erk |
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PIAS |
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Erk |
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Feedback |
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SUMO |
Inhibition |
C/EBPβ |
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NF-κB |
TF |
Stat3 |
PTP |
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AP-1 |
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etc. |
TF |
Stat3 |
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CIS, SOCS, Mcl-1, APPs, TIMP-1, |
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Accessory |
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ISRE/GAS |
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TF Motif |
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Pim-1, c-Myc, cytokines, TFs, etc. |
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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