CST 2015 / poster-vesicle-trafficking
.pdf
Vesicle Trafficking in Presynaptic
Neurons: Synchronous Release
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SYT |
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A |
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VAMP |
SYT |
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VAMP |
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SYT |
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VAMP VAMP |
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SYT |
SYT |
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VAMP |
VAMP |
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SYT |
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SYT |
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VAMP |
VAMP |
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VAMP |
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VAMP |
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SYT1 |
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SYT1 |
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2 |
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- |
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VAMP |
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VAMP |
Clathrin |
AP |
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Recycling |
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SYT1 |
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Vesicle |
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SYT1 |
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AP180 |
Amphiphysin |
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Dynamin |
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SYT1 |
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Docking |
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(NT) |
VAMP |
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Rab |
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Munc13 |
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Munc18- |
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SNAP25 |
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RIM-BP |
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RIM |
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Ca2+ |
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Syntaxin |
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Channel |
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C
B
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Priming |
SYT1 |
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(NT) |
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Munc13 |
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VAMP |
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RIM-BP |
Rab |
P25ANS |
1 Munc18-1 |
RIM |
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nStaxiny |
Ca2+
Channel
D
Munc13 |
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RIM |
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BP |
- |
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RIM |
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Rab
Super
Priming 
(NT)
VPMA |
SYT1 |
Complexin |
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1 |
Munc18 |
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- |
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1 |
Ca2+
Channel
Ca2+
Ca2+
Ca2+
Munc13
RIM |
Rab |
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RIM-BP |
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Fusion
and
Release
2+ |
2+ |
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Ca |
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Ca |
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SYT1 |
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VAMP |
Syntaxin |
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SNAP25Munc18 |
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- |
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1 |
Complexin
1
Ca2+ |
(NT) |
Channel |
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DAT
SERT 
EAAT
NT
Re-uptake
Postsynaptic Neuron
Pathway Diagram Key
Ion Channel/Transport
GTPase
Vesicle Formation/Trafficking
Select Reviews
This pathway diagram has been assembled by key opinion leaders in the field of Vesicle Trafficking in Presynaptic Neurons in collaboration with Cell Signaling Technology (CST) scientists. CST Pathways are reviewed and updated frequently to provide succinct and current overviews of the subject area. We would like to thank Prof. Taulant Bacaj, Stanford School of Medicine, Stanford, CA for contributing to this diagram.
Blakely, R.D. and Edwards, R.H. (2012) Cold Spring Harb. Perspect. Biol. 4, a005595. | Jahn, R. and Fasshauer, D. (2012) Nature 490, 201–207. | Saheki, Y. and De Camilli, P. (2012) Cold Spring Harb. Perspect. Biol. 4, a005645. | Südhof, T.C. (2013) Neuron 80, 675−690. | Südhof, T.C. (2013) Nat. Med. 19, 1227–1231. | Südhof, T.C. (2012) Neuron 75, 11–25.
© 2014 Cell Signaling Technology, Inc. Cell Signaling Technology® and CST™ are trademarks of Cell Signaling Technology, Inc.
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14PSTREFMNONE0211ENG_00