Signal Transduction

References

 1. Gilbert SF. The embryological origins of the gene theory. J Hist Biol. 1978;11:307–351.

 2. Gilbert SF. In friendly disagreement: Wilson, Morgan, and the embryological origins of the gene theory. Am Zoologist. 1987;27:797–806.

 3. Morgan TH. The Physical Basis of Heredity. Philadelphia: J.B. Lippincott; 1919.

 4. Morgan TH. The relation of genetics to physiology and medicine. In:

Nobel Lectures, Physiology or Medicine 1922–1941. Amsterdam: Elsevier; 1965:313–328.

 5. Arias AM. New alleles of Notch draw a blueprint for multifunctionality. Trends Genet. 2002;18:168–170.

 6. Poulson DF. Chromosomal deficiencies and the embryonic development of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1937;23:133–137.

 7. Poulson DF. Histogenesis, organogenesis and differentiation in the embryo of Drosophila melanogaster meigen. In: Demerec M, ed. Biology of Drosophila. New York: Wiley; 1950:168–274.

 8. Hartenstein V. Genetic analysis of early neurogenesis: dedicated to the scientific contributions of Jose A. Campos-Ortega (1940–2004). Dev Dyn. 2006;235:2003–2008.

 9. Campos-Ortega JA, Hartenstein V. Early neurogenesis in wildtype

Drosophila melanogaster. Roux’s Arch Dev Biol. 1984;193:308–325.

10.Doe CQ, Goodman CS. Early events in insect neurogenesis II. The role of cell interactions and cell lineage in the determination of neuronal precursor cells. Dev Biol. 1985;111:206–219.

11.Simpson P. The Notch Receptors. Austin TX: R G Landes; 1994.

730

Notch

12.Lissemore JL, Starmer WT. Phylogenetic analysis of vertebrate and invertebrate Delta/Serrate/LAG-2 (DSL) proteins. Mol Phylogenet Evol. 1999;11:308–319.

13.Logeat F, Bessia C, Brou C, et al. The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci U S A. 1998;95:8108–8112.

14.Kidd S, Lieber T. Furin cleavage is not a requirement for Drosophila Notch function. Mech Dev. 2002;115:41–51.

15.Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306:269–271.

16.Hambleton S, Valeyev NV, Muranyi A, et al. Structural and functional properties of the human notch-1 ligand binding region. Structure. 2004;12:2173–2183.

17.Fiuza UM, Arias AM. Cell and molecular biology of Notch. J Endocrinol. 2007;194:459–474.

18.Nichols JT, Miyamoto A, Weinmaster G. Notch signaling – constantly on the move. Traffic. 2007;8:959–969.

19.O’Connor-Giles KM, Skeath JB. Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila. Dev Cell. 2003;5:231–243.

20.Okajima T, Irvine KD. Regulation of notch signaling by o-linked fucose. Cell. 2002;111:893–904.

21.Okajima T, Xu A, Lei L, Irvine KD. Chaperone activity of protein O- fucosyltransferase 1 promotes notch receptor folding. Science. 2005;307:1599–1603.

22.Bruckner K, Perez L, Clausen H, Cohen S. Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature. 2000;406:411–415.

23.Okajima T, Xu A, Irvine KD. Modulation of notch-ligand binding by protein O-fucosyltransferase 1 and fringe. J Biol Chem. 2003;278:42340– 42345.

24.Heitzler P, Simpson P. The choice of cell fate in the epidermis of Drosophila. Cell. 1991;64:1083–1092.

25.Schroeter EH, Kisslinger JA, Kopan R. Notch-1 signalling requires ligandinduced proteolytic release of intracellular domain. Nature. 1998;393: 382–386.

26.Mumm JS, Schroeter EH, Saxena MT, et al. A ligand-induced extracellular cleavage regulates -secretase-like proteolytic activation of Notch1. Mol Cell. 2000;5:197–206.

27.Radtke F, Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer. 2003;3:756–767.

28.Black RA, Rauch CT, Kozlosky CJ, et al. A metalloproteinase disintegrin that releases tumour-necrosis factorfrom cells. Nature. 1997;385: 729–733.

731

Signal Transduction

29.Wolfe MS. The -secretase complex: membrane-embedded proteolytic ensemble. Biochemistry. 2006;45:7931–7939.

30.Shen J, Kelleher III RJ. The presenilin hypothesis of Alzheimer’s disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A. 2007;104:403–409.

31.Kovall RA, Hendrickson WA. Crystal structure of the nuclear effector of Notch signaling, CSL, bound to DNA. EMBO J. 2004;23:3441–3451.

32.Fortini ME, Artavanis-Tsakonas S. The suppressor of hairless protein participates in notch receptor signaling. Cell. 1994;79:273–282.

33.Struhl G, Adachi A. Nuclear access and action of notch in vivo. Cell. 1998;93:649–660.

34.Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA. Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev. 2002;16:1397–1411.

35.Tutter AV, Fryer CJ, Jones KA. Chromatin-specific regulation of LEF-1--catenin transcription activation and inhibition in vitro. Genes Dev. 2001;15:3342–3354.

36.Olave I, Reinberg D, Vales LD. The mammalian transcriptional repressor RBP (CBF1) targets TFIID and TFIIA to prevent activated transcription. Genes Dev. 1998;12:1621–1637.

37.Lecourtois M, Schweisguth F. The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling. Genes Dev. 1995;9:2598–2608.

38.Fischer A, Gessler M. Delta-Notch – and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors. Nucleic Acids Res. 2007;35:4583–4596.

39.Massari ME, Murre C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol Cell Biol. 2000;20:429–440.

40.Stern C, Tokunaga C. Autonomous pleiotropy in Drosophila. Proc Natl Acad Sci U S A. 1968;60:1252–1259.

41.Lai EC. Protein degradation: four E3s for the notch pathway. Curr Biol. 2002;12:R74–R78.

42.Fryer CJ, White JB, Jones KA. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell. 2004;16:509–520.

43.Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;433:760–764.

44.Poodry CA, Bryant PJ, Schneiderman HA. The mechanism of pattern reconstruction by dissociated imaginal discs of Drosophila melanogaster. Dev Biol. 1971;26:464–477.

45.Chen MS, Obar RA, Schroeder CC, Austin TW, Poodry CA, Wadsworth SC, Vallee RB. Multiple forms of dynamin are encoded by shibire, a Drosophila gene involved in endocytosis. Nature. 1991;351:583–586.

732

Notch

46.Hawryluk MJ, Keyel PA, Mishra SK, Watkins SC, Heuser JE, Traub LM. Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein. Traffic. 2006;7:262–281.

47.Le Borgne R, Remaud S, Hamel S, Schweisguth F. Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila. PLoS Biol. 2005;3(e96).

48.Bray SJ. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol. 2006;7:678–689.

49.Le Borgne R, Bardin A, Schweisguth F. The roles of receptor and ligand endocytosis in regulating Notch signaling. Development. 2005;132:1751– 1762.

50.Lobley A, Swindells MB, Orengo CA, Jones DT. Inferring function using patterns of native disorder in proteins. PLoS Comput Biol. 2007;3(e162).

51.Aguilar RC, Longhi SA, Shaw JD, et al. Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins. Proc Natl Acad Sci U S A. 2006;103:4116–4121.

52.Owen DJ, Collins BM, Evans PR. Adaptors for clathrin coats: structure and function. Annu Rev Cell Dev Biol. 2004;20:153–191.

53.Perry WL, Hustad CM, Swing DA, O’Sullivan TN, Jenkins NA, Copeland NG. The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice. Nat Genet. 1998;18:143–146.

54.Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development. 1995;121:2633–2644.

55.Ramain P, Khechumian K, Seugnet L, Arbogast N, Ackermann C, Heitzler P. Novel Notch alleles reveal a Deltex-dependent pathway repressing neural fate. Curr Biol. 2001;11:1729–1738.

56.Hori K, Fostier M, Ito M, et al. Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling. Development. 2004;131:5527–5537.

57.Cubas P, de Celis JF, Campuzano S, Modolell J. Proneural clusters of achaete-scute expression and the generation of sensory organs in the Drosophila imaginal wing disc. Genes Dev. 1991;5:996–1008.

58.Ghysen A. The projection of sensory neurons in the central nervous system of Drosophila: choice of the appropriate pathway. Dev Biol. 1980;78:521–541.

59.Usui-Ishihara A, Simpson P. Differences in sensory projections between macroand microchaetes in Drosophilid flies. Dev Biol. 2005;277: 170–183.

60.Rendel JM. A model relating gene replicas and gene repression to phenotypic expression and variability. Proc Natl Acad Sci U S A. 1969;64:578–583.

61.Hutterer A, Knoblich JA. Numb and -Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. EMBO Rep. 2005;6:836–842.

733

Signal Transduction

62.Lowell S, Benchoua A, Heavey B, Smith AG. Notch promotes neural lineage entry by pluripotent embryonic stem cells. PLoS Biol. 2006;4(e121).

63.Shen Q, Goderie SK, Jin L, et al. Endothelial cells stimulate self-renewal and expand neurogenesis of neural stem cells. Science. 2004;304:1338–1340.

64.Varnum-Finney B, Xu L, Brashem-Stein C, et al. Pluripotent, cytokinedependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med. 2000;6:1278–1281.

65.Crosnier C, Vargesson N, Gschmeissner S, et al. Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Development. 2005;132:1093–1104.

66.Fre S, Huyghe M, Mourikis P, Robine S, Louvard D, Artavanis-Tsakonas S. Notch signals control the fate of immature progenitor cells in the intestine. Nature. 2005;435:964–968.

67.Milano J, McKay J, Dagenais C, et al. Modulation of notch processing by -secretase inhibitors causes intestinal goblet cell metaplasia and

induction of genes known to specify gut secretory lineage differentiation. Toxicol Sci. 2004;82:341–358.

68.van Es JH, van Gijn ME, Riccio O, et al. Notch/ -secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature. 2005;435:959–963.

69.Ohlstein B, Spradling A. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature. 2006;439:470–474.

70.Axelrod JD, Matsuno K, Artavanis-Tsakonas S, Perrimon N. Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science. 1996;271:1826–1832.

71.Brennan K, Klein T, Wilder E, Arias AM. Wingless modulates the effects of dominant negative notch molecules in the developing wing of Drosophila. Dev Biol. 1999;216:210–229.

72.Hayward P, Brennan K, Sanders P, et al. Notch modulates Wnt signalling by associating with Armadillo/ -catenin and regulating its transcriptional activity. Development. 2005;132:1819–1830.

73.Itoh F, Itoh S, Goumans MJ, Valdimarsdottir G, et al. Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. EMBO J. 2004;23:541–551.

74.Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y. Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol. 2004;6:547–554.

75.Klupper M, Wrana JL. Turning it up a Notch: cross-talk between TGFβ and Notch signalling. Bioessays. 2005;27:115–118.

76.Blokzijl A, Dahlqvist C, Reissman E, et al. Cross-talk between the Notch and TGF-β signalling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol. 2003;163:723–728.

734