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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5672_Библиотеки_им_академика_М_И_Перельмана
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424
Metals in Medicine, Volume 2
FIGURE 13.11
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technologies have been applied in numerous research over the past ten years
-
array systems.
71,72
based predictors is not as good as previously assumed, even though enormous
-
73
A genome analysis
FIGURE 13.12 Protein-protein interactions.
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Metals in Medicine, Volume 2
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We need to learn more about the mysterious biomolecular characteristics
circumstances produce premalignant cells We need to use a study strategy
that incorporates the many components (molecular, cellular, and supracel-
TABLE 13.3 Gene Enrichment.
Enrichment
FDR
Number
of genes
Pathway
genes
Fold
enrichment
Pathways (click for details)
2 3 760.4
3 6 570.3 Basement membrane
2 5 456.2 Hydroxylation
3 11 311.1 Basement membrane, and G2F domain
4 17 268.4 Basement membrane, and hemidesmosome
2 10 228.1 Collagen trimer
2 13 175.5 Proteoglycan
3 22 155.5 Extracellular matrix
4 37 123.3 Basement membrane, and glycoprotein
complex
3 30 114.1
3 46 74.4 Collagen-containing extracellular matrix
4 77 59.2
3 61 56.1
4 90 50.7 Mixed, including m band, and basement
membrane
4 162 28.2
4 233 19.6 Supramolecular polymer
4 236 19.3
process
5 431 13.2 Supramolecular complex
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research indicates that this milieu is crucial in promoting and maintaining
cancer and aberrant cell development.
75
-
tion.
76,77
78
75
76,77
78
By
-
regulation, DNA repair, and signal transduction may become silenced as a
79,80
In these conditions,
an undiscovered process causes the stroma and epithelial cells to co-evolve
81,82
83–85
Actually, estrogens and progesterone can both
79
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Metals in Medicine, Volume 2
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87
-
-
several concerns regarding the study designs, data collecting and standard-
is increased as sometimes many more genes are being examined than there
are patients.
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-
13.11 CONCLUSION
-
include targeting via one or more ligands, therapy by their administration
and applications. For instance, both molecular imaging and targeted therapy
-
tionalities may be developed.
host stroma molecular data and tumor gene expression (radiation, surgery,
excretion, metabolism, and pharmacodynamics in in vivo animal models is
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Metals in Medicine, Volume 2
KEYWORDS
• nanoparticles
• cancer
• diagnosis
• gold nanoparticles
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