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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5672_Библиотеки_им_академика_М_И_Перельмана
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254
Metals in Medicine, Volume 2
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Several morpho-
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Impact of Metallic Nanoparticles for Tissue Engineering and Regenerative Medicine
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are better suited to encourage axon elongation.
82
impact on several bodily metabolic processes that either directly or indirectly
reactivity, translocation into cells, biocompatibility, medical imaging capa-
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in side a porous degradable matrix that acts as an ECM.
• Serve as osteogenesis stimuli.
• A bacterial-killing impact.
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Metals in Medicine, Volume 2
an interconnected porosity structure, and acceptable mechanical properties,
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and have a positive impact on both osteogenesis and angiogenesis. Si ions
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bone repair and regeneration in clinical settings.
88,89
It is also observed
demonstrated.
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Wound healing is still a hotly debated topic in modern medicine given the
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clinical concern.
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Due
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therapy.
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For instance,
E. coli
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Metals in Medicine, Volume 2
Candida albicans
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Ag are represented in Figure 8.4.
FIGURE 8.4
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8.3 SILVER NANOPARTICLES
FIGURE 8.5
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Metals in Medicine, Volume 2
Due to uses in biomedicine, AgNPs are receiving more and more attention.
are largely dependent on their physicochemical qualities. As a result, AgNP
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• XPS - X-ray photoelectron spectroscopy
• DLS - Dynamic light scattering
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• SEM - Scanning electron microscopy
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are key components in determining their cytotoxicity .
102–104
AgNPs have been
AgNPs have biological and medicinal uses such as antimicrobial, antibiotic,
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or positive and methicillin-resistant methicillin-resistant Staphylococcus
aureus (MRSA) strains by the silver nanocrystalline chlorhexidine (AgCHX)
complex.
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antibacterial clothing, and implantable devices coatings.
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in bacterial proteins, disrupt their metabolic response, and cause cell death.
According to Gurunathan et al.,
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probiotics, AgNPs, or AgNP mixtures
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organisms such as Pseudomonas aeruginosa, Shigella flexneri, S. aureus,
and Streptococci. When compared to either AgNPs or antimicrobials alone,
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traditional chemotherapy, and nanotechnology may hold the key.
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decreased metabolic activity , and cell viability , and enhanced oxidative stress
that resulted in DNA damage by damaging the mitochondria and producing
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According to a
arrested cells, apoptosis is induced.
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inorganic, and polymer materials, to enhance the optical properties.
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2
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concentration could be made
biological applications like optical labeling.
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techniques, including physical, chemical, and biological ones, have been
methods that combine chemical, physical, and biological techniques (Fig.
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the precursor salt.
121
FIGURE 8.6
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