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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5672_Библиотеки_им_академика_М_И_Перельмана
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354
Metals in Medicine, Volume 2
Battke et al.
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31
As
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33
34,35
11.4 IN VITRO STUDIES
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pollen,
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and plant development.
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Multiple human cellular models,
29,30
peripheral blood,
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cervical,
37–39
liver,
40
FIGURE 11.2
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ovarian,
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and cutaneous melanoma
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34,42,43
11.5 ANIMAL CELLS
Oncorhynchus mykiss-
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When treated acutely or subacutely, the
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11.6 HUMAN CELLS
Several distinct cellular models have been reported to experience varying
on the cells by the NPs.
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Wilkinson et al..
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Pd-NPs induced apoptosis in PBECs in a dose-dependent
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HeLa cells
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Metals in Medicine, Volume 2
Pd-NPs. Researchers discovered that human liver HepG2 cancer cells
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impact on HepG2 cells. An increase in concentration caused cytopathic
nonatopic
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-
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have a substantial immunological modulatory impact in vitro.
43
and allergic contact dermatitis.
45–47
In addition to having the ability to
48,49
Pd-NPs may be more bioactive than
al.
47
2
to
cell system to evaluate this latter point. Both healthy and injured human skin
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Toxicological Effect of Platinum and Palladium Nanoparticles
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50
51
the existing evidence, Pd-NPs are particularly risky to the immune, renal, and
exposure and early consequences. Elemental Pd excretion, cytokine serum
test it on more sophisticated organisms in more complicated environmental
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Escherichia coli and Gram-positive Staphylococcus
aureus
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-
activity in cultured E. coli and S. aureus
54–56
Cronobacter sakazakii
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Sphingomonas sp. PH-07,
-
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more antimicrobial. Pt-Pd nanometal colloids as isolated particles lack antibac-
connection among metal NPs and an all-polyaniline matrix, and the increased
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Metals in Medicine, Volume 2
Vibrio fischeri,
and actively bio-remediating associated microorganisms cultivated in the lab
under biogeochemical circumstances mimicking those occurring in situ
V. fischeri
the Pd-NPs-exposed population than in the control group. Currently, there is
reduction and methanogenesis in a dose-dependent manner. An experimental
31
soil organic components such as humic acids. Rajakumar et al.
38
reported that
Plasmodium ber ghei
mice, Pd-NPs exhibited antiplasmodial action. At an inhibitory concentration
NPs. Using a laboratory microenvironment to simulate natural conditions,
community.
31
humic acids. Rajakumar et al.
38
P. berghei
points compared to untreated controls.
11.7 ANIMAL MODELS
types.
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looked at subchronic periods.
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-
the urine.
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are being excreted in large amounts through the urine tract, it suggests renal
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a tail vein.
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-
normal sex hormone levels in Wistar rats, revealing that they play a key role
11.8 MODIFICATIONS OF PLATINUM- AND PALLADIUM-BASED
MOLECULES
Research into transition metal-based anticancer medicines has attracted a lot
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Metals in Medicine, Volume 2
compared to cisplatin and oxaliplatin. When the novel medications are modi-
59
-
-
tive routes to transition metal-based medicines.
60,61
An increasing number
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361
metals, such as transition metals like platinum, the resultant molecules
on cancer cells and their ability to damage cell DNA and other molecular
targets, these complexes stand out among conventional pharmaceuticals. It is
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and highly
63
It is possible to
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-
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-
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NPs
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producing lipid, polymer, and inorganic NPs, there is hope that they may
cells. Problems on a larger scale, such as biodistribution, may be overcome
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Metals in Medicine, Volume 2
synthesis procedures, meaning that their NPs could not get beyond these
biological obstacles to drug delivery. NPs are versatile because they may
even avoid drug resistance.
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Some NPs may generate heat in response to an
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the tissue around the tumor. As a result, the cancer cells acquire an increased
healthy tissue.
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-
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When it comes to delivering
polymeric NPs to lend them strength. Liposomes are more adaptable and
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71,72
Aroplatin is a liposomal
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common are poly (amidoamine) and poly (pyrrolidone) (PPI) (propylene
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major HA receptor and is highly expressed in breast, lung, and pancreatic
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static binding to the polyamidoamine dendrimers.
11.9 Pl-Pd COMPOUNDS IN CLINICAL TRIALS
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