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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5672_Библиотеки_им_академика_М_И_Перельмана
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Metals in Medicine, Volume 2
22
b. Paclitaxel:
ovary, breast, esophageal, pulmonary, and cervical malignan-
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to their role in causing cell death, mitochondria have recently
instance, the nanocomposite exhibited enhanced activity over
medicines and NPs that are untargeted.
-
numerous siRNA in metabolism, cell death, spread to distal organs, and
immunosuppression in malignancy has been documented.
24
SiRNA has been
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13.5 AN INNOVATIVE METHOD TO PREVENT TRANSCRIPTION IS
DNA INTERFERENCE (DNAI)
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Role of Gold Nanoparticles as Novel Agents for Cancer Diagnosis and Therapy
405
cell lines (breast cancer).
25
apoptosis. Other applications include rectal, sublingual, and buccal delivery
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13.6 TREATMENTS (PTT, PDT, AND RT)
PTT:
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a high photothermal conversion capacity that are delivered into the body,
the morphological and physical properties, such as the dimensions and shape
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26,27
PDT:
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Metals in Medicine, Volume 2
nearby O
2
21,28
Radiation therapy (RT)
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dose administered to the tumor locations until cell death occurs. Addition-
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13.7 DIAGNOSTICS
diagnosis and precision imaging-guided therapy at the same time, has thus
nuclear imaging and computed tomography (
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Role of Gold Nanoparticles as Novel Agents for Cancer Diagnosis and Therapy
407
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designed to communicate and target the analyte.
antigen (PSA) and miRNA-targeted gold NPs that have been correctly
31
32
× 10
Copri-
nopsis cinerea -
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Metals in Medicine, Volume 2
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change can be measured using a smartphone application.
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TABLE 13.2
Morphology Size (nm) Application
Nanostar 40
Nanosphere 5–10 Drug delivery and bioactivity
Nanocapsule 50
Nanocore 5.3 ± 0.7 Anticancer activity
Nanostar 7–10
Nanocapsule 30–40 Imaging
Nanosphere 5
Nanocube 50
Nanosphere 100
Nanosphere 73.8
Nanosphere 2.04 ± 0.18 Drug delivery
Nanosphere 19 Gene delivery
Nanocluster 2 Disease detection
Nanosphere 20–37 Anticancer and antimicrobial activity
Nanosphere 31
Nanobipyramid – Diagnosis
Nanosphere 15 Diagnosis
13.8 GREEN AU-NPS IN CANCER THERAPY
permeability, minimal cytotoxicity, and excellent stability, green synthe-
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Role of Gold Nanoparticles as Novel Agents for Cancer Diagnosis and Therapy
409
cancer. Au-NPs typically disperse across the lymphatic system, enabling the
Due to their ability to accumulate in tumors at the cellular level and their
present application in targeted medication administration green synthetic
an aquatic bacterial species (Vibrio alginolyticus
against colorectal cancer through apoptosis-induced cellular death. Flax-
seeds (Linum usitatissimum
Thymus vulgaris
Curcuma longa), is credited
mediator during biosynthesis, Au-NPs can take on a spherical shell shape
cell lines or glioma cells (C-6), and they only released curcumin under
physiological conditions.
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Metals in Medicine, Volume 2
Additionally, the given Au-NPs generated a considerable decrease in the
-
ated on people as an antibreast cancer medication.
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Turbinaria decurrens
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37
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Tecomaria capensis-
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Furthermore, since the next-generation sequencing (NGS) data processes
do not yet have these methodologies integrated into industry-standard
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Role of Gold Nanoparticles as Novel Agents for Cancer Diagnosis and Therapy
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to multiplexedly detect proteins and nucleic acids at high throughput have
the potential to make substantial advancements in molecular diagnostics.
tissue, single-cell level or organ level.
is a developing revolution that parallels the assay process by simultane-
sequencing cost.
to more traditional methods, these technologies seek to drastically decrease
pathogenic process begins.
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in physiological processes.
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Metals in Medicine, Volume 2
13.9NEW NANOBIOTECHNOLOGICAL PERSPECTIVES IN DIAGNOSIS
It is not designed to achieve genetic heterogeneity in tissue specimen because
that have been detected and clinical–epidemiological data. Regarding
39
various applications, including medical imaging and diagnostic procedures,
40
41
Contrast in ultrasonic imaging relies
on impedance mismatch caused by objects like metals, ceramics, or micro-
42
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tion as the nanobased contrast mediators continue to evolve, giving them a
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Role of Gold Nanoparticles as Novel Agents for Cancer Diagnosis and Therapy
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Nucleic acid chemistry and photolithography have enabled the devel-
devices.
43,44
Using the same expertise that made assimilated circuits possible,
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diagnostic, genotyping, and biomarker-guided therapy targeting have all
45,47,48
Additionally , developments
in proteomics have been made possible by improvements in lithographic
resolution.
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cial techniques.
50
early response to the therapy, biosensors that are exceedingly sensitive and
51,52
For a
clinical samples. Peptide nucleic acid probes are used in highly sensitive
(PCR).
53–55
diagnostic applications. A multiplexed method is desired to precisely sense
56–58
judicious treatment assortment based on bigger data groups, and quicker
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