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☆
4 General Approach toPsychopharmacological Treatment During thePerinatal Period
77
As reported by an editorial published many years ago by Robinow, but still quite truthful: “The stark reality is that pregnancy in the context of a history of mental
illness often leaves the mother, the baby, and their doctors between Scylla and Charybdis” (Robinow 2006).
It would be desirable as well as appropriate that both the investments in clinical psychopharmacological research programs and the dissemination of reliable infor­mation on fetal and gestational safety of PDs were seen also as an essential tool for the improvement of women’s mental health care during the perinatal period.

References

Anand A, Phillips K, Subramanian A, etal. Prevalence of polypharmacy in pregnancy: a system-
atic review. BMJ Open. 2023;13:13e067585. Andrade C. Genes and unmeasured and unknown confounds in studies of neurodevelop-
mental outcomes after antidepressant prescriptions during pregnancy. J Clin Psychiatry.
2020;81(3):20f–3463. Anya AWW, Stevens DS, Gossen PJJ, etal. Risk of mood disorders during pregnancy and the
impact of medication. A systematic review. J Affect Disorders. 2019;249:96–103. Bind RH, Sawyer K, Pariante C.Depression in pregnancy: biological, clinical, and psychosocial
effects. In: Percudani M, Bramante A, Brenna V, Pariante C, editors. Key topics in perinatal
mental health. Springer; 2022. Cohen LS, Altshuler L, Harlow BL, Nonacs R, Newport DJ, Viguera AC, Suri R, Burt VK,
Hendrick V, Reminick AM.Relapse of major depression during pregnancy in women who
maintain or discontinue antidepressant treatment. JAMA. 2006;295(5):499–507. Erratum in:
JAMA. 2006;296(2):170 Eleftheriou G, Zandonella-Callegher R, Butera R.Consensus panel recommendations for the phar-
macological management of pregnant women with depressive disorders. J Environ Res Public
Health. 2023;20:6565. Eleftheriou G, Zandonella Gallagher R, Butera R, etal. Consensus panel recommendations for
the pharmacological management of breastfeeding women with postpartum depression. Int J
Envirom Res Public Health. 2024;21:551. Frayne J, Ellies R, Nguyen T. Experiences of decision making about psychotropic medication
during pregnancy and breastfeeding in women living with severe mental illness: a qualitative
study. Arch Womens Ment Health. 2023;26:379–87. Freeman MP.Perinatal psychiatry: an emerging specialty. J Clin Psychiatry. 2014;75(10):1086–7. Grigoriadis S, Vonder Porten EH, Mamisashvili L, Roerecke M, Rehm J, Dennis CL, Koren G,
et al. Antidepressant exposure during pregnancy and congenital malformations: is there an
association? A systematic review and meta-analysis of the best evidence. J Clin Psychiatry.
2013;4(4):e293–308. Grigoriadis S, Wilton AS, Kurdyak PA, etal. Perinatal suicide in Ontario, Canada: a 15-year pop-
ulation-based study. CMAJ. 2017;189:E1085. Howard LM, Khalifeh K.Perinatal mental health: a review of progress and challenges. World
Psychiatry. 2020;19:313–27. Huybrechts KF, Palmsten K, Mogun H, Kowal M, Avorn J, Setoguchi-Iwata S, Hernández-Díaz
S.National trends in antidepressant medication treatment among publicly insured pregnant
women. Gen Hosp Psychiatry. 2013;35(3):265–71. Huybrechts K, Palmsten K, Avorn J, etal. Antidepressant use in pregnancy and the risk of cardiac
defects. N Engl J Med. 2014;370(25):2397–407. LactMed. Retrieved on 10th January, 2025; 2023. Available at https://www.nlm.nih.gov/pubs/fact-
sheets/lactmedfs.html
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Louik C, Lin AE, Werler MM, Hernández-Díaz S, Mitchell AA.First-trimester use of selec-
tive serotonin-reuptake inhibitors and the risk of birth defects. N Engl J Medicine.
2007;356(26):2675–83. Erratum in: N Engl J Med 2015; 373(7):686 McAllister-Williams RH, Baldwin DS, et al. Endorsed by the British Association for
Psychopharmacology. British Association for Psychopharmacology (BAP). Consensus guid-
ance on the use of psychotropic medication preconception, in pregnancy and postpartum 2017.
J Psychopharmacol. 2017;31(5):519–52. Orsolini L, Bellantuono C.Psychotropic drugs in pregnancy and breastfeeding (chapter 16). In:
Percudani M, Bramante A, Brenna V, Pariante C, editors. Key topics in perinatal mental health.
Springer Nature Switzerland; 2022. Orsolini L, Valchera A, Vecchiotti R, Tomasetti C, Iasevoli F, Fornaro M, De Berardis D, Perna
G, Pompili M, Bellantuono C.Suicide during perinatal period: epidemiology, risk factors and
clinical correlates. Front Psych. 2016;7:138. Percudani M, Bramante A, Brenna V, Pariante C, editors. Key topics in perinatal mental health.
Springer Nature Switzerland; 2022. Robinow DR.Antidepressant treatment during pregnancy. Between Scylla and Charybdis. Am J
Psychiatry. 2006;163(6):954–6. Robinson R, Lahti-Pulkkinen M, Heinonen K.Fetal programming of neuropsychiatric disorders
by maternal pregnancy depression: a systematic mini-review. Paediatr Res. 2019;85:134–45. Smith CJ, Payne WM.Epidemiology of studies of effects on lithium salts are confounded by the
inability to control for other potentially teratogenic factors. Human Exp Toxicol. 2024;43:1–16. Stein A, Pearson RM, Goodman SH, Rapa E, Rahman A, McCallum M, Howard LM,
Pariante CM. Effects of perinatal mental disorders on the fetus and child. Lancet.
2014;384(9956):1800–19. Stevenson K.Fetal programming and epigenetics. Curr Opin Endocr Metab Res. 2020;12:1–6. Suarez EA, Bateman BT, Hernandez-Diaz S.Association of antidepressant use during pregnancy
with risk of neurodevelopmental disorders in children. JAMA Int Med. 2022;182(11):1149–60. Viguera A. Polypharmacy for perinatal mood and anxiety disorders. Lancet Psychiatry.
2024;11(8):575–7. Viguera AC, Whiteld T, Baldessarini RJ, Newport DJ, Stowe Z, etal. Risk of recurrence in women
with bipolar disorder during pregnancy: prospective study of mood stabilizer discontinuation.
Amer J Psychiatry. 2007;164(12):1817–24. Wang S, Ding C, Du C, Zhu Z, Zhang D, Yi O.Associations between maternal prenatal depression
and neonatal behavior and brain function–evidence from the functional near-infrared spectros-
copy. Psychoneuroendocrinology. 2022;146:105896. WHO. Guideline: protecting, promoting and supporting breastfeeding in facilities providing
maternity and newborn services. Geneva: World Health Organization; 2017. Wisner KL.The last therapeutic orphan: the pregnant woman. Am J Psychiatry. 2012;169(6):554–6.
C. Bellantuono
The Role ofPaternal Mental Health During thePerinatal Period: FromPreconception toPostpartum
GiuliaFrancesconi, RosaVolgare, UmbertoVolpe, andLauraOrsolini

5.1 Introduction

Paternal health and lifestyle behaviors are critically unrepresented in reproductive health discussions. Despite being formally acknowledged as a vital component of reproductive health, paternal involvement in clinical practice and assessment is often overlooked (Montagnoli etal. 2021). Paternal traits and behaviors may inu­ence offspring’s physical and mental health through both direct genetic inheritance and epigenetic modications, as well as through indirect mechanisms that overly affect the maternal environment. Direct effects include epigenetic changes in sperm caused by lifestyle choices such as diet and smoking, which can alter gene expres­sion patterns and affect offspring’s phenotypes across generations (Donkin and Barrès 2018; Sharp etal. 2019) impacting on the behavioral and cognitive charac­teristics (Yeshurun and Hannan 2019). Indirect paternal effects inuence the mater­nal environment through behaviors such as smoking, alcohol consumption, and stress, which can harm both the mother and the child or affect maternal behaviors that are important for the child’s health (Scheffers-van Schayck etal. 2019; Braun etal. 2020). These modications can affect offspring phenotypes, including suscep­tibility to chronic diseases such as obesity and diabetes (Fleming etal. 2018).
Recently, increasing attention has been given to paternal mental health. Evidence from several human studies suggested that preconception paternal mental health may be associated with adverse health outcomes in their offspring through both genetic and non-genetic mechanisms (Coleman etal. 2020). Depression in fathers before conception is linked to late preterm births, excessive infant crying, and potential changes in newborn’s brain structure, such as accelerated white matter
5
G. Francesconi · R. Volgare · U. Volpe · L. Orsolini (*) Unit of Clinical Psychiatry, Department of Experimental and Clinical Medicine (DIMSC), Polytechnic University of Marche, Ancona, Italy e-mail: l.orsolini@staff.univpm.it
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2025 F. Uguz, L. Orsolini (eds.), Perinatal Psychopharmacology,
https://doi.org/10.1007/978-3-031-99720-4_5
79
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development (van den Berg etal. 2009; Karlsson etal. 2020; Spry etal. 2020). A recent study revealed that men diagnosed with depression before pregnancy had offspring with increased attention-decit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) risks (Chen etal. 2020). It is possible that precon­ceptional paternal depression persisted to the postnatal stage to affect children via altered parenting styles with fewer positive activities, such as reading, singing, and hugging, and a higher level of conict in the father-child relationships making it difcult to satisfy the child’s attachment in their early years and potentially affect­ing the development of a psychopathology later in childhood or adulthood. Family factors, such as maternal depression and couple conicts, could also mediate the association between paternal postnatal depression and child outcomes (Tan et al.
2023). The underlying biological mechanisms are still unclear. Special attention
should also be paid to the use of psychoactive drugs, with selective serotonin reup­take inhibitors (SSRIs) and valproic acid among the most studied substances, that have been hypothesized to be associated with the occurrence of neurodevelopmen­tal disorders in children born from fathers who used these substances in the pre­conception period (Evans-Hoeker et al. 2018; Yang et al. 2018; Montagnoli etal. 2021).

5.2 Paternal Mental Health

Fathers have become increasingly more involved in parenting due to mothers’ grow­ing active roles in the workforce, cultural changes regarding masculinity and father­hood, and greater equality in gender roles. While maternal mental health issues such as depression, stress, and anxiety are well-documented contributors to adverse child outcomes (Barona etal. 2017; Cook etal. 2018; Tuovinen etal. 2018; Vehmeijer etal. 2019), the impact of paternal mental health remains less clear (Sweeney and MacBeth 2016; Gentile and Fusco 2017; Cui etal. 2020; Challacombe etal. 2023). Several studies indicated that preconception paternal mental health may signi­cantly impact offspring’s mental, cognitive, and behavioral health through genetic and non-genetic mechanisms (Yeshurun and Hannan 2019; Coleman etal. 2020). Preconception paternal mental health, including depression and anxiety, seemed to correlate with offspring risks for mental health conditions such as ADHD, ASD, and emotional disturbances. These effects could be due to altered parenting styles (e.g., fewer positive interactions, and increased conicts) due to psychiatric pathologies (Chen etal. 2020; Tan etal. 2023). Maternal mental health appears to correlate with paternal mental health. Paulson and Bazemore (2010) reported a correlation between paternal and maternal depression during the prenatal and postnatal periods, suggest­ing that paternal depression could inuence maternal depression, which could adversely affect fetal and infant development through a spillover effect. Additionally, females mated with stressed males exhibit altered maternal care, further impacting offspring health, suggesting a bidirectional inuence on child outcomes (Chen etal.
2020; Zutshi etal. 2021; Tan etal. 2023). Paternal mental health is also important
when considering fertility. Depression has been diagnosed in up to 49% of male
5 The Role of Paternal Mental Health During the Perinatal Period…
81
partners suffering from infertility, while female partners of depressed men are less likely to conceive. Although human and animal studies have demonstrated the asso­ciation between father’s mental health and an increased risk of adverse health out­comes in their offspring, the underlying biological mechanisms are unclear. Further research is therefore needed, although recently paternal mental health has become an emerging area of research interest, with a special focus on depression.
5.2.1 Paternal Mental Health: Depressive Disorders
Approximately 10% of fathers have symptoms that meet the criteria for depressive episodes of varying severity in the perinatal period (Fisher 2016) which is approxi­mately half the rate of maternal postpartum depression (14–18%) (Liu etal. 2022). Perinatal paternal depression (PPD) can begin as early as the rst trimester of preg­nancy to 1 year after the birth of the child, though it most commonly emerges around 4 weeks postpartum (DSM-5-TR) (APA 2013). Several paternal factors may increase the risk of depression during the peripartum period. These include unem­ployment, legal problems, addiction, neurotic personality traits, nancial strain, an unplanned pregnancy, and distress related to the imminent birth. Additionally, a lack of social support, avoidant coping strategies, low self-esteem, exposure to negative life events, poor sleep quality, and perceived stress can further contribute to this risk (Wang etal. 2021). Among these, maternal depression emerged as the most signi­cant factor inuencing paternal peripartum depression, with severe depression in the partner appearing to increase the father’s risk of major depressive disorder (MDD) up to 50% (Wee etal. 2011). Similarly, a positive family and/or personal history of depression appears to inuence the occurrence of depression (Goodman
2004). Several studies conrmed that marital dissatisfaction is a robust risk factor
for paternal perinatal depression. There is also some evidence suggesting that infant factors, such as difcult temperament and feeding challenges, may play a role in increasing the risk of paternal depression, though research in this area is less exten­sive. The mechanisms determining the onset of perinatal depression in fathers are currently not completely dened. Certainly, the disruption of the circadian rhythm and sleep deprivation for childcare represent potential determinants. The nightly activities and care needs of the child can negatively impact fathers’ productivity in their work, which is typically uninterrupted. This dynamic makes it challenging for fathers to adjust to their new role, often leading to increased frustration (Sokół- Szawłowska 2020).
Depression in men may manifest differently compared to the female counterpart. Clinical studies reported that men usually display increased irritability, impulsivity, persistent sadness, anxiety, dysphoria, low self-esteem, stiffness of affect, feelings of isolation, social withdrawal, disrupted eating patterns, insomnia, tendency to abuse substances (sometimes as part of autotherapy), self-harm ideation, and, in some cases, suicidal thoughts (Addis 2008; Da Costa etal. 2019; Bruno etal. 2020). The different clinical picture can make diagnosis difcult as well as man’s tendency to downplay his mental state. It is important to consider that when comparing men
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and women, men are less likely to report their experiences of depression in the same way that women do and they also less likely seek treatment, mainly due to poor social support, inability to express feelings of sadness/depression for the fear to be judged and/or for internal stigma (Carlberg etal. 2018). As a result, paternal perina­tal depression has been underreported, underrecognized, underdiagnosed, and undertreated.
The most common assessment screening tool is the Edinburgh Postnatal Depression Scale (EPDS) (Kozinszky and Dudas 2015). Other tools available to assess paternal depression are represented by the Gotland Male Depression Scale (GMDS) (Sigurdsson etal. 2015), the Masculine Depression Scale (Magovcevic and Addis 2008), the Male Depression Risk Scale (Herreen et al. 2022), and the Beck Depression Inventory-II (BDI-II). Diagnosis is needed since depressive symp­tomatology may signicantly alter the father-infant relationship modifying the child’s development and response to stress, with studies showing an association between a father’s depressed mood and negative temperament in the child, a higher emotional dysregulation (Ramchandani etal. 2008), and a higher occurrence of both internalizing (sadness, anxiety, or physical symptoms like stomachaches) and externalizing (aggression, oppositional behavior, property destruction, or misbehav­ior like stealing) problems (Cross etal. 2024). Furthermore, it has also been demon­strated an association between a father’s depressed mood and the emergence of reduced social skills, and higher rates of psychiatric disorders in children, particu­larly at school age (Gentile and Fusco 2017). There is also evidence that fathers’ depression during their offspring’s childhood can be associated with offspring’s mental health problems, most frequently anxiety and depression, during the transi­tion to adulthood (Fisher 2016). Furthermore, depressed fathers display a worse quality in the interaction with their children. They are less prone to play face-to-face with the child, impairing the child’s communication skills. Depressed fathers more likely manifest their violence toward family members compared to healthy fathers and tend to be less engaged in offering a cognitive stimulation for their children (Sweeney et al. 2016; Sundstom et al. 2017; Sokół-Szawłowska 2020; Cross etal. 2024).
Moreover, one should argue that depression is often accompanied by poor nutri­tion, substance use, stress, and lack of exercise, which may also lead to alterations in sperm that can, in turn, adversely affect offspring (Yeshurun etal. 2019; Hoek etal. 2020). Conversely, the involvement of a non-depressed father may protect against some of the offspring risks associated with maternal depression (Melrose 2010).
Relatedly, paternal depression puts the mother at increased risk for depression as well, indirectly contributing to a further increased childhood risk for psychopathol­ogy. This can result in a higher prevalence of psychopathological symptoms during preschool years and an increase in psychiatric diagnoses by the time they reach school age (Cross etal. 2024). Interestingly, some ndings contradict these associa­tions. Higher paternal depressive symptoms during the prenatal period were associ­ated with fewer child behavioral difculties, particularly lower externalizing symptoms like conduct and hyperactivity problems. Interestingly, indeed, greater
5 The Role of Paternal Mental Health During the Perinatal Period…
83
paternal depression and anxiety symptoms measured during childhood seemed to correlate with higher child Intelligence Quotient (IQ) (Jones etal. 2023). Therefore, one should argue that there are complex and nuanced relationships between paternal mental health and child development, mostly still not fully investigated and under­stood, which suggests a careful approach and the need for more longitudinal studies to fully understand these dynamics. Finally, a recent study showed evidence of an association between preconception parental mental health disorders and preterm birth, with persistent common mental disorder symptoms across adolescence and young adulthood showing the greatest impact. Little evidence of an association between paternal antenatal mental health disorders and small for gestational age was found. The underlying process has not yet been identied (Spry etal. 2020).
5.2.2 Paternal Mental Health: Anxiety Disorders
Anxiety appears to be more prevalent than depression among new fathers. A sys­tematic review conducted by Leach etal. (2016) found that anxiety seemed to affect around 4–16% of fathers during the prenatal period and around 2–18% in the post­natal period. Paternal anxiety is highly comorbid with depression, and it may include a variable set of symptoms including worries, fear, physical complaints, and cognitive symptoms. Fathers are at risk for increased anxiety levels during preg­nancy, postpartum, and throughout child development, with levels comparable to mothers. Risk factors include having children with chronic illnesses, low- birthweight infants, or co-parents with mental health issues, as well as low social support and poor marital quality (Luoma etal. 2013; Cimino etal. 2015). Paternal anxiety cor­relates with child internalizing and externalizing behaviors and other psychiatric conditions, highlighting a clear longitudinal connection between paternal anxiety and adverse child outcomes. Anxious fathers often exhibit overprotective, overin­volved parenting styles, which can model and reinforce anxiety in children. These behaviors, even occurring in infancy, may hinder children’s development of inde­pendence and increase their risk of psychopathology (Breaux etal. 2014; Möller et al. 2015; Fisher 2016). A recent study showed that fathers’ prenatal anxiety symptoms are associated with lower dehydroepiandrosterone (DHEA) levels and higher rates of internalizing symptoms in children. In conclusion, these ndings highlight the often overlooked importance of paternal factors during pregnancy in child development, suggesting that prenatal paternal anxiety symptoms may be associated with the child’s neuroendocrine function and, in turn, with internalizing symptoms that occur at least until middle childhood (Jones etal. 2024).
5.2.3 Paternal Mental Health: Bipolar Disorders
Bipolar disorder in fathers, characterized by episodes of mania, hypomania, and depression, impacts interparental and parent-child relationships and, ultimately, the child’s emotional health. Research mainly found higher rates of manic, hypomanic,
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and mixed episodes in fathers during the postpartum period, compared to the gen­eral population (Pinheiro etal. 2011). Children of fathers with bipolar disorder face a signicantly increased risk of bipolar and other mood, anxiety, and externalizing disorders. While bipolar disorder affects parenting behaviors and self-efcacy, gen­der-specic impacts on fathers’ parenting styles remain under-investigated. Maladaptive parenting style associated with bipolar disorder seems to be linked with the emergence of children’s internalizing and externalizing problems, despite more studies being needed to clarify this relationship (Fisher 2016).
5.2.4 Paternal Mental Health: Posttraumatic Stress Disorders
Research on posttraumatic stress disorder (PTSD) in fathers found that traumatic experiences, such as witnessing a difcult birth, dealing with a child’s serious ill­ness, or exposure to natural disasters and war, can lead to intrusive memories, avoid­ance, negative mood, and heightened arousal. These symptoms impair paternal functioning and parenting, negatively affecting children’s mental health (Nicholls and Ayers 2007). Fathers who develop PTSD from childbirth trauma may struggle with bonding and interparental relationships, affecting infant outcomes (Ribi etal.
2007). Fathers with PTSD often exhibit externalizing parenting behaviors, such as
irritability and detachment, contributing to their children’s anxiety, depression, and behavioral problems. One study showed that the child’s gender and age may be determinants of the type of behavioral problems resulting from paternal PTSD: pre­adolescent girls had somatic complaints and aggression, while adolescent girls showed more depressive symptoms; pre-adolescent boys were more anxious, while adolescent boys had somatic complaints and hyperactivity. Overall, paternal PTSD, regardless of its cause, signicantly hinders functional parenting and poses a risk to children’s emotional and behavioral health (Fisher 2016).
5.2.5 Paternal Mental Health: Obsessive-Compulsive Disorders
Obsessive-compulsive disorder (OCD) in fathers is one of the least explored pater­nal mental health conditions. This disorder is characterized by intrusive and recur­rent thoughts or images (obsessions) and/or ritualistic and repetitive behaviors that relieve anxiety (compulsions), causing signicant distress and being difcult to control. Currently, there is no data available on the prevalence of OCD in fathers, but it seems to be linked to maladaptive parenting styles. A study conducted by Yoshida etal. found that fathers with OCD or depression with severe obsessive traits tended to be signicantly more overprotective of their children than fathers without obsessive traits or with mild obsessive traits (Yoshida etal. 2005). However, the available evidence is insufcient to determine with certainty the impact of paternal OCD on parenting behavior and children’s mental health (Fisher 2016).
5 The Role of Paternal Mental Health During the Perinatal Period…
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5.2.6 Paternal Mental Health: Substance Use Disorders
Alcohol and other substances, such as tobacco, cannabis, alcohol, and recreational drugs, have been extensively demonstrated to exert teratogenic effects when con­sumed prenatally by the mother, contributing to developmental delays, physical anomalies, and growth defects in offspring. Paternal substance use seems to signi­cantly affect fertility, pregnancy outcomes, and offspring health through genetic and epigenetic mechanisms or via social, psychological, or behavioral inuences on the maternal environment (Abel 2004; Thomas etal. 2023).
Paternal smoking is a modiable risk factor that signicantly inuences preg­nancy and infant health. It is important to consider that paternal smoking has a direct effect on fetal development through secondhand smoke. While no studies report a direct association between paternal smoking and small for gestational age or decreased birth weight of the offspring, it is known that paternal smoking, even light smoking, increases the risk of heart defects. The father’s smoking habit is also associated with an increased risk of overweight and obesity (odds ratio [OR]=1.41, 95% condence interval [CI]=1.17–1.85), the development of childhood leukemia, and appears to negatively impact offspring lung function. It has also been linked to higher rates of ADHD in offspring (Carter etal. 2023).
Regular cannabis use during adolescence, a critical period for testicular develop­ment, has been linked to reduced sperm concentration, lower total sperm count, signicant testicular atrophy, impaired reproductive hormones, and male infertility (Durairajanayagam 2018; Montagnoli etal. 2021). Cannabis use before conception has also been associated with increased pregnancy loss, decreased birth weight in children, and behavioral and neurodevelopmental problems in offspring. These effects are thought to result from changes in cholinergic synaptic function and related behavioral outcomes (Slotkin etal. 2020).
Opioids appeared to impair male fertility by altering reproductive hormones and spermatogenesis. Their use is associated with reduced testicular volume and erectile dysfunction. Additionally, cocaine and opioid addiction in fathers has been linked to low birth weight, early mortality, and ADHD in children (Fang et al. 2018; Montagnoli etal. 2021). Paternal morphine exposure has been shown to increase behavioral vulnerability to addiction in male offspring through long-lasting neural adaptations in reward pathways (Toussaint etal. 2022).
Paternal alcohol consumption also affects fertility and pregnancy outcomes (Finelli etal. 2021). Alcohol consumption impairs the quality of spermatozoa by reducing their number, motility, and morphology. These effects have been observed even after 1 month of abstinence, suggesting that alcohol-induced changes in sper­matozoa may last for weeks or months (Roach etal. 2024). In addition, preconcep­tion paternal alcohol consumption alters the hormone balance, essential for reproduction (Bedi etal. 2022; American Addiction Centre 2025). The effects of paternal alcohol use extend beyond the embryonic stage, negatively impacting preg­nancy outcomes and the health of offspring. Paternal alcohol use has been linked to higher rates of miscarriage, stillbirth, and low birth weight. Additionally, paternal alcohol use disorder (AUD) has been associated with increased risks of congenital
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anomalies and infant mortality (Klonoff-Cohen etal. 2003). Children of fathers who drank heavily before conception have also been found to exhibit higher rates of behavioral and mental health problems, mostly represented by ADHD, hyperactiv­ity, anxiety, depression, and sleep disorders (Easey and Sharp 2021; Lo etal. 2024; Jansen etal. 2024). These effects often manifest early in life, with risks peaking at ages 2, 4, and 6. Interestingly, girls appear to show higher rates of emotional reactiv­ity and cognitive challenges compared to boys who are more likely to display somatic complaints and rule-breaking behaviors (Luan etal. 2022). The association between fathers’ alcohol consumption and an increased risk of neurodevelopmental disorders is also signicant. A recent study by May etal. (2023) suggested that paternal alcohol use may increase the risk of fetal alcohol spectrum disorders (FASD)—a condition characterized by cognitive difculties (problems with learn­ing, memory, attention, and problem-solving skills), behavioral disorders (impulsiv­ity, hyperactivity, and difculty with self-regulation), problems in interpersonal interactions, and physical abnormalities (distinctive facial features, growth delays, and organ anomalies) (Berlina 2024). May etal. (2023) found that fathers of chil­dren with FASD are more likely to have a history of heavy drinking. On average, these fathers consume 9.2 drinks per occasion, compared to 4.8 drinks in control groups, and exhibit signicantly higher rates of AUD.Although the mechanisms remain unclear, this association raises the possibility that paternal alcohol use may inuence FASD risk through genetic or environmental factors, or by affecting fam­ily dynamics and maternal health. A recent Swedish study (Khemiri etal. 2023) explored the impact of paternal AUD on the offspring’s risk of intellectual disability (ID), a neurodevelopmental disorder with altered cognitive, social, and physical development (DSM 2013). The exact mechanisms remain unclear, but probably the paternal alcohol use near conception may induce genetic mutations or epigenetic changes, contributing to ID risk. Moreover, the relationship between paternal alco­hol consumption and child outcomes appears to be dose-dependent: the more a father drinks, the greater the risks for his children (Luan etal. 2022).
5.3 The Impact ofPaternal Psychopharmacotherapy
Most studies evaluating the safety of parental drug exposure during pregnancy and conception primarily focus on maternal exposure. However, recent publications have also highlighted the potential impact of paternal drug exposure on pregnancy outcomes. Antipsychotics, anxiolytics, hypnotics, sedatives, and antidepressants are frequently prescribed to fathers (Wensink etal. 2021) with some studies showing an association between the use of some of these medications and the occurrence of negative changes in sperm quality, as well as an increased risk of fetal mortality and impaired fetal growth (Baumgartner etal. 2001; Safarinejad 2008; Engeland etal.
2013; Akasheh etal. 2014). In a prospective study by Wensink etal. (2022), rates of
preterm births were slightly higher in the drug-exposed groups (>6%) than in the unexposed group (5%). Birth defects were generally similar between the two groups (3.3–3.9% exposed vs 3.3% unexposed). The only drug group that showed a slightly