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References

225
stump of the SFA (endarterectomized) or off the graft itself as was the case here. Since this was an in situ conguration, the vein graft hood should be large enough that when you are sutur­ing at directly onto a prosthetic graft material, it should not scar down. However, if a reversed saphenous vein bypass graft is used, it may end up scaring at the prosthetic vein interface, and an anastomosis to native artery should be considered.
Pseudoaneurysms may also be a sign of infec­tion, usually indolent, if late as is the case here [4]. Oftentimes, the graft is non-incorporated and may or may not have perigraft uid present. It is beyond the scope of this commentary, but in situ options exist for repair, including rifampin­soaked Dacron as well as using ePTFE.Overall, aortofemoral bypasses are durable procedures but do certainly have complications. One quite rare and one common late complication is noted
here, but this procedure should remain an option for vascular surgeons in their treatment of aor­toiliac disease.
References
1. Gloriczki P, Cross A, Stenson AW, Carr M, Bower TC, et al. Ischemic injury to spinal cord a lumbar-sacral plexus as after aorto-iliac reconstruction. Am J Surg. 1991;162:131–6.
2. Bredahl K, Jensen LP, Schroeder TV, Sillesen H, Nielsen H, Eiberg JP. Mortality and complica­tions after aortic bifurcated bypass procedures for chronic aortoiliac occlusive disease. J Vasc Surg. 2015;62(1):75–82.
3. Rosenthal D. Spinal cord ischemia after abdomi­nal aortic operation: is it preventable? J Vasc Surg. 1999;30(3):391–7.
4. Seabrook GR, Schmitt DD, Bandyk DF, Edmiston CE, Krepel CJ, Towne JB.Anastomotic femoral pseudoan­eurysm: an investigation of occult infection as an etio­logic factor. J Vasc Surg. 1990;11(5):629–34.
Part XII
Aorto-Mesenteric Bypass
Mesenteric Revascularization inPatients withAcute onChronic Bowel Ischemia
53
Patient A: History andPhysical Examination
A 70-year-old female was seen in the outpatient clinic in June 2002 with symptoms of postpran­dial abdominal pain, anorexia, gas pains, loss of weight, and diarrhea of 6–9 months duration. Medical comorbidities included Type II diabetes mellitus, coronary artery disease with remote coronary artery bypass graft, hyperlipidemia, hypothyroidism, and stage III chronic kidney dis­ease. She underwent CTA of the abdomen and pelvis which showed 70% stenosis of the celiac artery and occlusion of the rst two centimeters of the superior mesenteric artery. She was admit­ted to the hospital as an emergency because of right lower quadrant pain in July 2002.

Patient A: Procedure

She was started on IV heparin and underwent antegrade aorto-superior mesenteric bypass graft with 8mm PTFE interring prosthesis via midline transperitoneal approach in July 2002. After the division of the left triangular ligament, left lobe of the liver was retracted toward the right. Dissection was done by opening the gastrohe­patic omentum, the esophagus with nasogastric tube was retracted toward the left, and deep blades of the retractor system (Bookwalter III retractor system, Symmetry Surgical, Antioch,
TN) were inserted to expose the right crus of the diaphragm. The muscular bers of the right crus were separated with long Metzenbaum scissors so that a 5–6cm long opening was made in the crus. The preaortic fascia over the aorta was divided, and supraceliac aorta was exposed and mobilized in its anterior aspect and on each side for a length of 3–4cm.
Superior mesenteric artery was exposed at the
root of the small bowel mesentery after mobiliz­ing the ligament of Treitz. It was exposed on the left side of the superior mesenteric vein, and it had no pulse. A tunnel was made posterior to the posterior wall of the body of the stomach but anterior to the body of the pancreas through the right side of the transverse mesocolon. Intravenous heparin (8000units) was adminis­tered by the anesthesia team; a Satinsky clamp was applied to supraceliac aorta near its occlud­ing lumen. Aortotomy incision 5.5–2 cm long was made, and edges of the aorta were divided by curved scissors to open the aortotomy. An 8 mm INTERING PTFE (W.L. Gore Inc., Newark, DE) was anastomosed end to side to the supraceliac aorta and end to end to the divided superior mesenteric artery. Patient had excellent superior mesenteric artery pulse distal to the bypass. The pale caecal wall at the time of lapa­rotomy became pink in color. In the ensuing few months, patient had weight gain and was relieved of her symptoms of intestinal angina. In 2010 patient presented with ischemic ulceration with
© Springer Nature Switzerland AG 2020 S. S. Hans, Challenging Arterial Reconstructions, https://doi.org/10.1007/978-3-030-44135-7_53
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53 Mesenteric Revascularization inPatients withAcute onChronic Bowel Ischemia
osteomyelitis of the left big toe with gangrenous changes. She underwent CO2 with low-dose con­trast arteriography of the abdominal aorta and lower extremities (Fig.53.1). CO2 was preferred as patient’s chronic kidney disease has pro­gressed to stage IV. She underwent left femoral endarterectomy and a left femoral popliteal bypass graft on June 2010. An 8mm PTFE pros­thesis was used as greater saphenous vein in the left leg has been used for coronary bypass graft. In July 2010, patient had below-knee amputation
following failure of the left femoral popliteal bypass graft. Patient subsequently expired in October 2010.
Patient B: History andProcedure
A 60-year-old female in August 1989 underwent aorto-bifemoral graft and proximal anastomosis end to end with a 14 × 7 mm knitted Dacron graft. Patient’s main symptoms were intermittent
Fig. 53.1 Postoperative (abdominal aortogram) showing patent aorto-superior mesenteric artery bypass and few
enlarged visceral collaterals

Discussion

231
Fig. 53.2 Aortogram showing juxtarenal aortic occlusion
with occlusion of proximal superior mesenteric artery and small IMA
claudication; she was found to have juxtarenal aortic occlusion and occlusion of proximal 3cm segment of superior mesenteric artery, a patent inferior mesenteric artery, and a right common femoral artery occlusion (Fig. 53.2). After the proximal anastomosis was completed (proximal anastomosis end to end) and distal aorta was sutured shut above the inferior mesenteric artery, the terminal 6 inches of the small intestine became ischemic. Greater saphenous vein was harvested from the right upper thigh, and a 5- centimeter length of the greater saphenous vein in a reversed fashion was sutured to the proximal right limb of the Dacron graft and to the superior mesenteric artery (retrograde approach) (Fig.53.3). The small bowel regained its normal color. Patient was seen 8 years later with symptoms of abdominal pain and some weight loss. Aortogram was performed which showed occlusion of the graft. Patient was offered antegrade bypass, but she refused any further surgical intervention.
Fig. 53.3 Retrograde bypass from the Dacron graft to the
superior mesenteric artery
Discussion
The diagnosis of chronic mesenteric ischemia is increasing because of better awareness of its symptoms and readily availability of duplex ultrasound scan for evaluating patients with sus­pected mesenteric artery occlusive disease. The optimal method of treatment and type of revascu­larization (open versus endovascular) and type of surgical repair (transaortic endarterectomy ver­sus aortomesenteric bypass grafting; antegrade versus retrograde bypass) remain controversial [1]. In most series, long-term patency after revas­cularization with objective means is lacking. Endovascular therapy is signicantly less inva­sive but is only successful in patients with ste­notic lesions of the visceral arteries. Antegrade synthetic aortomesenteric bypass is associated with long-term graft patency and satisfactory functional outcome as reported by Jimenez etal. in 47 patients with in-hospital mortality of 11% and with primary assisted and secondary 5-year graft patency of 69% [2].
232
53 Mesenteric Revascularization inPatients withAcute onChronic Bowel Ischemia
Both patients in this report had a follow-up of 8 years. The rst patient had an abdominal aor­tography and study of the lower extremities for ischemic lesions of the left foot. The second patient in this report had subsequent occlusion of the graft (retrograde bypass graft), but the exact time of the occlusion cannot be determined.
Invited Commentary from Frank M.Davis, MD, andPeter K.Henke, MD
The diagnosis and management of chronic mes­enteric ischemia (CMI) remains a challenge and has a considerable morbidity and risk of mortal­ity for patients aficted with this condition. Although the exact incidence of CMI remains unknown, current estimates indicate that this condition accounts for less than 1 per 100,000 hospital admissions in the United States; how­ever, recent investigations suggest that CMI admissions are increasing [3, 4]. For patients aficted with CMI, classic symptoms include abdominal pain, weight loss, and “food fear.” The abdominal pain is often postprandial and begins within a few minutes to 30minutes after meals, persisting for as long as 5–6 hours. Unintentional weight loss can progress to mal­nutrition and cachexia, which is often present at the time of intervention. In some patients, clini­cal presentation of CMI can be less specic with vague abdominal pain, nausea, vomiting, or change in bowel habits, without the classic post­prandial component. Lastly, a minority of patients can remain completely asymptomatic as prior autopsy studies have shown that 6–10% of people have a greater than 50% stenosis in at least one mesenteric artery; in those with periph­eral vascular disease, the incidence may be as high as 27% [5]. CMI patients often have tradi­tional atherosclerotic risk factors with tobacco history, hypertension, and hyperlipidemia docu­mented in more than 60% to 70% [6, 7]. Given the variable nature of symptoms combined with the potential overlap with other disease pro­cesses, the diagnosis of CMI remains elusive and can delay treatment.
One of the most devastating complications of CMI is mesenteric arterial thrombosis resulting in acute mesenteric ischemia (AMI). Acute arte­rial thrombosis superimposed on preexisting severe atherosclerotic disease represents that sec­ond most common cause of AMI as up to 20% of AMI patients have demonstrated a history of CMI, with symptoms of abdominal pain, food avoidance, or weight loss [8, 9]. For patients who progress from CMI to AMI, the classic symptom includes “abdominal pain of out proportion to exam” for early mesenteric ischemia. Yet this may be absent in 20–25% of cases, depending on the cause and timing of presentation [10]. Until transmural ischemia has developed, there is rela­tively little peritoneal irritation, thus minimizing tenderness to palpation. Further, in contrast to patients who develop AMI secondary to an embolic event, patients who develop acute on chronic mesenteric ischemia often have bowel infarction that is more insidious in onset because extensive collaterals are able to maintain viability until there is nal closure of a critically stenotic vessel or collateral. As such, a high index of sus­picion in the setting of a compatible history and physical examination serves as a cornerstone of prompt treatment. Regarding the diagnostic algo­rithm for AMI, there has been a paradigm shift. Older models advocated early and aggressive use of diagnostic arteriography; however, this has now largely been supplanted with computed tomographic angiography (CTA) when AMI is suspected. The use of ultrafast multidetector CTA (MDCTA) for the evaluation of both acute and chronic mesenteric ischemia is well described [11]. The widespread availability of the newest generation of CT scanners has advanced the diag­nostic algorithm for AMI, providing a signicant amount of information about the central arterial and venous circulations.
Once a diagnosis of acute on chronic mesen­teric ischemia is achieved, the goal of therapy for patients is the prompt restoration of blood ow to the visceral organs. Patients presenting with signs and symptoms of AMI require urgent abdominal exploration, assessment of bowel viability, and revascularization. Several techniques for the res­toration of intestinal perfusion are available

References

233
including endarterectomy, antegrade arterial bypass, retrograde arterial bypass, or hybrid revascularization. For arterial bypass in an emer­gent setting, a single bypass to the SMA is all that is required, and graft orientation is inuenced mainly by the degree of atherosclerosis and occlusive disease present in the inow vessels and by the overall lie of the graft. As such, a ret­rograde graft orientation is common with its ori­gin from the right common iliac artery in a “lazy C” conguration. This avoids any aortic clamp­ing with the increased hemodynamic stress and usually provides a good lie to prevent kinking. Alternatively, a hybrid open retrograde mesen­teric stenting can be performed for acute athero­sclerotic SMA thrombosis. This technique combines a less invasive mesenteric revascular­ization without compromising important general surgical principles. Recent small single center studies have demonstrated acceptable outcomes with a hybrid approach [7]. A solely endovascu­lar treatment modality is not generally applied due to the potential need for bowel resection. As described previously, operative bypass to the SMA is traditionally required owing to the extent of disease. In recent years, mortality after revas­cularization for AMI has declined from 50% in the 1990s to 30% in the 2000s; however, mortal­ity remains high in patients with AMI even after successful surgical revascularization [3]. Factors associated with increased mortality were renal insufciency, age older than 70years, metabolic acidosis, symptom duration, and need for bowel resection during second-look operations [12]. Lastly, owing to high recurrence rates, both short­and long-term follow-up is critical for maintain­ing the patency of open and especially endovascular revascularized vessels [13].
Within this current chapter, the authors detail two cases of acute on chronic mesenteric isch­emia and associated operative repair. These cases highlight the variable nature of patient presenta­tion for AMI as well as the diversity of surgical procedures available to treat this potentially
lethal condition. The technical issues are well delineated and outcomes overall good.
References
1. Scali ST, Ayo D, Giles K, Gray S, etal. Outcomes of antegrade and retrograde open mesenteric bypass for acute ischemia. J Vasc Surg. 2019;69:129–40.
2. Jimenez JZ, Huber TS, Ozaki CK, Flynn TC, etal. Durability of antegrade synthetic aortomesenteric bypass for chronic mesenteric ischemia. J Vasc Surg. 2002;35:1078–84.
3. Schermerhorn ML, Giles KA, Hamdan AD, Wyers MC, Pomposelli FB. Mesenteric revascularization: management and outcomes in the United States, 1988–2006. J Vasc Surg. 2009;50(2):341–8.. e341
4. Mitchell EL, Moneta GL. Mesenteric duplex scanning. Perspect Vasc Surg Endovasc Ther. 2006;18(2):175–83.
5. Valentine RJ, Martin JD, Myers SI, Rossi MB, Clagett GP. Asymptomatic celiac and superior mesenteric artery stenoses are more prevalent among patients with unsuspected renal artery stenoses. J Vasc Surg. 1991;14(2):195–9.
6. Pecoraro F, Rancic Z, Lachat M, etal. Chronic mes­enteric ischemia: critical review and guidelines for management. Ann Vasc Surg. 2013;27(1):113–22.
7. Kasirajan K, O’Hara PJ, Gray BH, et al. Chronic mesenteric ischemia: open surgery versus per­cutaneous angioplasty and stenting. J Vasc Surg. 2001;33(1):63–71.
8. Mansour MA.Management of acute mesenteric isch­emia. Arch Surg. 1999;134(3):328–30;discussion 331
9. Endean ED, Barnes SL, Kwolek CJ, Minion DJ, Schwarcz TH, Mentzer RM Jr. Surgical management of thrombotic acute intestinal ischemia. Ann Surg. 2001;233(6):801–8.
10. Howard TJ, Plaskon LA, Wiebke EA, Wilcox MG, Madura JA. Nonocclusive mesenteric isch­emia remains a diagnostic dilemma. Am J Surg. 1996;171(4):405–8.
11. Horton KM, Fishman EK. Multidetector CT angiog­raphy in the diagnosis of mesenteric ischemia. Radiol Clin N Am. 2007;45(2):275–88.
12. Kougias P, Lau D, El Sayed HF, Zhou W, Huynh TT, Lin PH.Determinants of mortality and treatment out­come following surgical interventions for acute mes­enteric ischemia. J Vasc Surg. 2007;46(3):467–74.
13. Kanamori KS, Oderich GS, Fatima J, etal. Outcomes of reoperative open or endovascular interventions to treat patients with failing open mesenteric recon­structions for mesenteric ischemia. J Vasc Surg. 2014;60(6):1612–9.. e1611–2
Part XIII
Infrainguinal Arterial Bypass Graft
Femoral-Peroneal Bypass forCritical Limb Ischemia inaPatient withUnstable Angina
54
History andPhysical Examination
A 76-year-old male with history of signicant coronary artery disease (prior coronary artery bypass graft, coronary stenting, pacemaker) was admitted to the emergency room with ischemic rest pain with associated paresthesias involving the right foot. Other medical comorbidities included hypertension, chronic renal failure (cre­atinine 2.1% mg), and nicotine abuse. Examination of the right lower extremity pulses revealed that all the pulses were absent below the right femoral artery level. Doppler arterial study showed absent ow in the right dorsalis pedis and posterior tibial artery with unrecordable ankle brachial index and toe brachial index. Patient developed increasing symptoms of cardiac isch­emia (angina) at rest and was started on IV hepa­rin and underwent urgent coronary vascularization with stenting of circumex branch of coronary artery.

Procedure

After the patient was stabilized from cardiac standpoint, he underwent right lower extremity arteriography which showed occlusion of the right supercial femoral artery from the midseg­ment to involve the popliteal artery. Posterior tibial artery and anterior tibial arteries were also occluded. The runoff was by a patent peroneal
artery which showed 60% stenosis in its midseg­ment (Fig. 54.1). Right greater saphenous vein had been used for coronary bypass graft in the past. Patient underwent right proximal supercial femoral to peroneal artery bypass using contra­lateral non-reversed greater saphenous vein. The valve lysis was performed with retrograde valvu­lotome following proximal anastomosis. Peroneal artery was exposed in its middle to distal segment via a medial approach using tourniquet occlu­sion, and distal anastomosis to the peroneal artery inferior to the stenotic area was performed (Fig.54.2). Peroneal artery was slightly less than 2 millimeters in diameter. Patient had a satisfac­tory postoperative course. Patient was seen in October 2019 with patent right femoral-peroneal bypass with normal velocities on duplex imag­ing, and a follow-up CTA showed patent right femoral-peroneal bypass (Fig.54.3).

Discussion

Greater saphenous vein is a proven conduit of choice for infrainguinal arterial bypass because of its length, size compatibility, and durability. Ipsilateral greater saphenous vein is inadequate in 20% of patients [1]. The optimal alternative conduit for lower extremity revascularization in such circumstances remains an issue of ongoing debate. Prosthetic grafts are clearly inferior to autogenous conduits for infragenicular
© Springer Nature Switzerland AG 2020 S. S. Hans, Challenging Arterial Reconstructions, https://doi.org/10.1007/978-3-030-44135-7_54
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54 Femoral-Peroneal Bypass forCritical Limb Ischemia inaPatient withUnstable Angina
Fig. 54.1 Preoperative arteriogram showing occlusion of
the distal two third of right supercial femoral artery and popliteal artery. Occlusion of posterior tibial and anterior
Fig. 54.2 Exposure of the distal peroneal artery arteriotomy with blue silastic loops and anastomosed with distal anas-
tomosis with not reversed contralateral saphenous vein
reconstructions. Chew etal. reported 226 autog­enous infrainguinal reconstructions in 203 patients using contralateral greater saphenous vein (31%), single segment lesser saphenous vein (5%), single segment arm vein (19%), and autog­enous composite vein (45%) [1]. They observed that the 5-year patency rates were signicantly better for contralateral greater saphenous vein. Conte et al. noted that patients requiring lower extremity arterial bypass present increasingly complex medical and surgical challenge in recent years characterized by increasing age, increased proportion of women, and higher prevalence of
tibial artery with runoff with peroneal artery with midseg­ment stenosis
the National Surgical Quality Improvement Program database identied 6978 patients from 2012 to 2015 who underwent infrainguinal arte­rial bypass; of those, 327 (4.7%) had severe chronic kidney disease and 550 (7.9%) were on hemodialysis [3]. They concluded that chronic kidney disease is a signicant predictor of peri­operative morbidity and mortality following lower extremity arterial bypass [3]. Patients with severe chronic kidney disease have worse postop­erative outcomes with increased mortality. Those on hemodialysis have worse survival and postop­erative outcomes [3].
diabetes and renal disease [2]. Ambur etal. from