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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_905_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Foreword
- •Preface
- •Prologue to First Edition
- •Prologue to Second Edition
- •Further Reading
- •Contents
- •Introduction
- •Editor and Contributors
- •About the Editor
- •Contributors
- •References
- •Conclusion
- •3: Surgical Decision-Making: More Questions than Answers?
- •Introduction
- •Intraoperative Decision-Making
- •Overlooked Behaviors Impacting Surgical Decision-making Outcomes
- •The Never Event
- •Conclusion
- •References
- •Introduction
- •Personality Characteristics
- •Conclusion
- •References
- •Introduction
- •Primum Non Nocere
- •The Never Event
- •Sleep
- •Conclusion
- •References
- •Introduction
- •Situation Awareness, Perception, Comprehension, Projection
- •Conclusion
- •References
- •Introduction
- •Augmented Reality During Surgery
- •Overall Surgical Complications
- •Surgical Risk Models
- •The MySurgeryRisk Platform
- •Sepsis
- •Pancreatic Fistula
- •Hepatic Surgery
- •Transplant
- •Frailty
- •Disposition
- •Anesthesia
- •Pain Management
- •Cancer Treatment
- •Gastric Cancer
- •Detecting Preinvasive Occult Pancreatic Ductal Adenocarcinoma
- •Colorectal Cancer
- •Conclusions
- •References
- •Technological Adjuncts
- •Perioperative Monitoring
- •Functional Coagulation Assay Driven Resuscitation
- •Acute Kidney Injury
- •Extracorporeal Membrane Oxygenation
- •Bedside Laparotomy
- •Nutritional Considerations
- •Patient Centered Care Goals
- •Summary
- •References
- •Postinjury Multiple Organ Failure (MOF)
- •Decision-Making Around Interventions
- •Interventional Radiology
- •Surgery
- •Decision-Making Around Surgical Critical Care
- •Pulmonary
- •Cardiac
- •Renal
- •Hepatic
- •References
- •Introduction
- •Postoperative Complications Requiring Reoperation
- •Infection Complications: Source Control
- •Missed Enterotomies
- •Summary
- •References
- •Introduction
- •Postoperative Enterocutaneous Fistulas
- •Summary
- •Necrotizing Soft Tissue Infections
- •Postoperative Necrotizing Soft Tissue Infections (NSTIs)
- •The Management
- •Summary
- •Intestinal Ischemia
- •Summary
- •Open Cholecystectomy
- •Summary
- •The Burst Abdomen
- •The Management
- •Summary
- •References
- •Introduction
- •Hemostatic Resuscitation: Damage Control Resuscitation (DCR)
- •System-Based Damage Control Surgery
- •Damage Control Laparotomy
- •Summary
- •References
- •Introduction
- •The Component Separation Techniques
- •Onlay Placement
- •Underlay Placement
- •Bridge Mesh Placement
- •Summary
- •References
- •Introduction
- •The Medically Complex Pediatric Surgical Patient
- •Testicular Torsion
- •Midgut Volvulus
- •Trauma
- •Ileocolic Intussusception
- •Use Cases
- •Use Case 1: Neonatal Abdominal Catastrophes
- •Anorectal Malformations
- •Myelomeningocele
- •Intestinal Atresia
- •Complicated Appendicitis (Abscess or Phlegmon Formation)
- •Complicated Inguinal Hernias
- •Inhaled Foreign Bodies
- •Ambiguous Genitalia
- •Use Case 2: Rare Renal Tumors
- •Use Case 3: Pediatric Traumatic Amputations
- •Complex Congenital Anomalies
- •Suggested Readings
- •15: Surgical Decision-Making: Melanoma
- •Introduction
- •Preoperative Decision-Making
- •Intraoperative Challenges
- •Challenging Referrals
- •Sentinel Node Biopsy After Previous Excision
- •References
- •Laparoscopic Banding
- •Band Slippage
- •Pouch Enlargement
- •Band Erosion/Perforation
- •Port Complications
- •Laparoscopic Sleeve Gastrectomy
- •Bleeding
- •Leak
- •Stenosis
- •Gastric Bypass
- •Intro
- •Early Complications
- •Bleeding
- •Leak
- •Inaccurate Construction
- •Late Complications
- •Small Bowel Obstruction
- •Stenosis
- •Fistula
- •References
- •Introduction
- •Multidisciplinary Team Meeting
- •Preoperative
- •Intraoperative
- •Postoperative
- •Case 1
- •Case 2
- •Case 3
- •Case 4
- •References
- •Introduction
- •Acute Pancreatitis
- •Diagnosis
- •Gallstone pancreatitis
- •Hemorrhagic Complications
- •The Pregnant Patient
- •Choledocholithiasis
- •Intraoperative Conduct
- •Common Bile Duct Injury
- •Pancreatic Trauma
- •Surgical Options
- •Post-Surgical Care
- •Liver Trauma
- •Hepatic Injury Grading
- •Management Options
- •Conclusion
- •References
- •Introduction
- •The Decision-Making Process
- •Conclusions
- •References
- •Background
- •Ostomy Surgery
- •Colon Cancer
- •Rectal Cancer
- •Colonic Stenting
- •References
- •Introduction
- •Imaging: CTA, MRI, TEE
- •Morphologic Aortic Assessment
- •Technique
- •Introduction
- •The Operation
- •Eversion Endarterectomy
- •Complications
- •Conclusion
- •Introduction
- •Procedural Steps
- •Conclusion
- •The May–Thurner Syndrome
- •Anatomy
- •Clinical Presentation
- •Imaging Studies
- •Conservative Treatment
- •Conclusions
- •Management After Access Is Created
- •References
- •Sect. 1: Introduction
- •Sect. 2: Modern Management of Acute Aortic Dissection
- •Sect. 3. Carotid Endarterectomy—Can We Make a Good Operation Better? Technical Considereations
- •Sect. 4: Use of Advanced Peripheral Arterial Techniques for Limb Salvage: Role of Intravascular Lithotripsy
- •Sect. 5. The May–Thurner Syndrome
- •Sect. 6: Evaluation of a Patient for Hemodialysis Access
- •Sect. 7: Summary and Future of Vascular Surgery
- •Introduction
- •Primary Survey
- •Airway
- •Breathing
- •Circulation
- •Disability
- •Exposure/Environment
- •Management priorities
- •Damage Control Resuscitation (DCR)
- •Traumatic Brain Injury (TBI)
- •Abdominal Injuries
- •Damage Control Laparotomy
- •Non-operative management
- •Thoracic Injuries
- •Orthopedic Management
- •Prophylactic Antibiotics
- •Multidisciplinary Care
- •Team Collaboration
- •Sugested Readings
- •Introduction
- •General Remarks
- •Emergency Management
- •Evaluation
- •Management
- •Antimicrobial Therapy
- •Dental Hard Tissues
- •Endodontium
- •Periodontium
- •Alveolar Bone
- •Substance-Saving Restorations
- •Interdisciplinary coNcept
- •Post-initial Treatment
- •Conclusions
- •References
- •Expected vs. Unexpected Deaths
- •Second Victim Syndrome
- •Guilt
- •Acceptance
- •Burnout
- •Conclusions
- •References
- •What Is Burnout?
- •At Risk Population
- •Burnout vs. Stress
- •Measuring Tools
- •Causes
- •Burnout Prevention
- •Recovering
- •Conclusion
- •References
- •References
- •Introduction
- •Conclusion
- •References
- •Further Readings
- •Introduction
- •References
- •Index

250
Fig. 21.8 Example of aortic measurement of TL and FL in the dissected aortic segment
I. A. Laskowski et al.
All TBAD patients are admitted to the intensive care unit for initial management and necessary evaluation. If additional better-quality
imaging is required prompt thin cut contrast
enhanced computed tomography of the thorax,
abdomen and pelvis (CTA) is performed. If absolute contraindications to iodinated contrast exist,
Magnetic Resonance Angiography (MRA)may
be utilized for further anatomic evaluation.
When isolated TBAD with organ malperfusion is present, an emergent repair using endovascular options is considered as the rst line of
therapy. In cases of frank aortic rupture, patients
either undergo emergent open repair or multidisciplinary approach by vascular and cardiothoracic senior team members used to evaluate
endovascular options and formulate treatment
plan.
For patients with non-complicated, high risk
features dissection with presence of two lumens,
immediate medical management with blood pressure and impulse control is implemented. High
risks feature TBAD is dened in cases when total
aortic lumen is >40 mm, false lumen >22 mm,
proximal aortic tear >10mm, there is presence of
ongoing chest pain regardless of blood pressure
control, history of poor compliance with medical
management of hypertension, and evidence of
organ malperfusion on imaging [31]. Following
qualication for surgical intervention timing of
repair is dened as hyperacute when treated
within rst 24h of presentation, acute-days 1–14
and subacute for those treated between day 15
and 90th day of presentation. Majority of our
patients undergo repair during acute phase for
isolated TBAD, and subacute for the residual dissection following TAD repair.
Imaging: CTA, MRI, TEE
All patients undergo baseline imaging evaluation
that consisted of computed tomography angiography (CTA) with multiplanar reconstruction or
gadolinium-enhanced magnetic resonance angiography when needed. Interprocedurally, all
patients undergo transesophageal echocardiography for baseline assessment of aortic arch and
ascending and proximal descending aorta for
evaluation of a possibility of retrograde Type A
dissection, new pericardial effusion, or any other
acute changes.

21 Surgical Decision-Making in Vascular Surgery: Practical Approaches to New Innovative Techniques…
251
Morphologic Aortic Assessment
Preoperative imaging was used for morphologic
assessment of the entire aorta with assessment of
aortic false lumen patency status, aortic arch
involvement, and proximity to left subclavian
artery, patency of aortic branch vessels with
determination of the take-off from true or false
lumen, and degree and symmetry of end-organ
perfusion. Femoral access is evaluated in detail
with particular attention to the extent of dissection and patency and diameter of iliac arteries,
quality and diameter of femoral arteries with
potential involvement in dissection, presence of
atherosclerotic disease, and the level of femoral
bifurcations bilaterally. This is especially important since we routinely use preclose technique
with Perclose, Proglide devices (Abbott
Cardiovascular Systems, IL, USA).
Preoperative Planning andAortic
Dissection
As a rst step of preoperative planning of aortic dissection, we assess proximal extent of the dissection
based on Ishimaru Zones. We always want to select
aortic segment free of pathology as close to 2cm in
length for the proximal landing zone of the aortic
stent graft. For elective cases, we attempt to preserve ow into left subclavian artery that is achieved
by either revascularization with carotid to subclavian bypass grafting or with the use of Thoracic
Branch Endograft (Gore and Ass, Flagstaff, AZ,
USA). In all cases of FL visceral branch origin, we
protect the branch vessels with a Glide Wire or end
lumen catheter during distal aortic stenting with
subsequent branch vessel patency and adjunct
branch vessel stenting as needed (Fig.21.8).
Technique
We perform all aortic dissection cases under general anesthesia in the hybrid operating room with
the use of digital subtraction angiography. All
patients undergo neuromonitoring with somatosensory evoked potential (SSEP) and motor
evoked potential (MEP) throughout the case. We
do not use cerebrospinal uid drainage on routine
basis. Bilateral ultrasound-guided percutaneous
access with use of preclose Perclose ProGlide system technique is applied for the main device delivery. If ilio-femoral dissection is present,
preferentially the non-dissected side is used for the
device deployment. For initial vascular access, a
Bentson wire (Boston Scientic, Marlborough,
MA, USA) with 100 cm Pig tail catheter (Cook
Medical) support is advance to ascending aorta
with subsequent exchange for a 300 cm double
curve Lunderquist® extra-stiff wire (Cook
Medical). Contralateral diagnostic Pigtail catheter
is advanced in a similar fashion and positioned in
the ascending aorta. Femoral venous access is routinely established for temporary percutaneous pacing wires that are placed in the right ventricle.
They are used for rapid cardiac pacing during stent
deployment and during aortic angioplasty with
rate set to 180 to 200bpm. In the next step, aortic
arch angiogram is performed and using information from the preoperative CTA, intraoperative
conrmation of the position of arch vessels is
made and nal level of the proximal deployment
of the rst stent is selected. In cases where L SCA
is involved and when GORE Thoracic Branch
Endograft (TBE) is used, we obtain additional
through and through wire access from the left
wrist and out of the large sheath of the main device
delivery as per Gore device IFU.In all other cases,
our to go to device is Zenith TX2 when deployed
into the native aorta or Zenith Alpha (Cook
Medical) covered stents when deployment is into
preexisting Dacron graft of either ascending aortic
repair or an elephant trunk repair. For all cases
requiring left SCA coverage that do not meet anatomic criteria for TBE, we perform carotid -tosubclavian bypass usually a day or two prior to the
aortic stenting procedure.
Once proximal stent graft is in place, we continue
to deploy covered stents to the level just proximal to
celiac trunk. We do that to assure that all secondary
tears of the aortic dissection ap are excluded as distally as possible. In our experience, this prevents
ongoing false lumen ow that may lead to early
repair failure. Once all covered stents are in place,
we proceed with Zenith Dissection uncovered stents

252
I. A. Laskowski et al.
deployment in the remaining abdominal aorta all the
way to the level of iliac bifurcation. At this point for
those patients that Petticoat approach is intended,
this completes the procedure.
Since in our experience, STABILISE technique has excellent outcomes we attempt it in all
patients with TBAD that meet anatomic criteria
of aortic diameters. We use modied criteria rst
established by Melissano and his group [32].
That part of the procedure is performed with a
46 mm Coda molding balloon (Cook), and the
entire stented segment of the aorta to the infrarenal segment is angioplastied while rapid cardiac
pacing is employed (Fig. 21.7). The goal is to
dilate true aortic lumen to the total aortic diameter as per measurements from the preoperative
imaging. In the next step, we perform conrmatory intravascular ultrasound of the entire aorta to
determine presence of residual false lumen and
we repeat aortic angioplasty at these levels until
false lumen obliteration was achieved.
We routinely employ wire protection of all
aortic branch vessels that come off the false
lumen during aortic angioplasty (Fig.21.9).
After intervention patients are observed in the
intensive care unit with routine neurovascular
checks and to maintain mean arterial pressures in
the 90–100mmHg range for rst 72h. Patients
are on standard DVT prophylaxis, and antiplatelet regimen with aspiring 81mg daily is implemented in those cases where TBED or adjunct
branch vessel stenting was performed.
Patient undergo repeat CTA chest abdomen
and pelvis evaluation before discharge to assess
aortic remodeling results with particular attention to false, true and total lumen diameters,
false lumen ow, and presence of endoleaks,
type A retrograde dissection, and all organ
perfusion.
To date, over 30 patients were treated using
this approach with no intraoperative mortality
and no aortic rupture in the course of aortic molding balloon. When compared to Petticoat,
STABILISE technique achieved signicantly
smaller false lumen diameter and resultant abrogation of false lumen ow on follow-up imaging
(Fig.21.10). In addition, we did not observe retrograde type A dissection, open conversion, and
new aortic branch vessel compromise or occlusion. We also did not observe neurologic complications both during the intervention and in the
postoperative period. Realizing that more studies
are needed to fully evaluate this approach, we
feel that our treatment algorithm allows therapeutic options for patients with this challenging
condition.
Fig. 21.9 Branch vessel wire protection and stenting after completion of aortic remodeling

21 Surgical Decision-Making in Vascular Surgery: Practical Approaches to New Innovative Techniques…
Fig. 21.10 Aortic remodeling after STABILISE technique on pre- and postoperative CTA imaging
253
Carotid Endarterectomy—Can
WeMake aGood Operation Better?
Technical Considerations
Introduction
In the year 1913, James Ramsey Hunt, a young
neurology attending from Columbia University
presented a paper at the New York Academy of
Medicine highlighting the role of carotid arteries
in the causation of stroke [33]. Till that time, it
was believed that stroke was essentially an intracranial pathology—hemorrhage, thrombosis, or
tumor. Based on autopsy studies of brain and
neck, Ramsey Hunt linked extracranial carotid
artery disease to intracranial pathology. Miller
Fisher, a Canadian neuropathologist who later
headed the department in Harvard coined the
term TIA (Transient Ischemic Attack) and furthered our understanding of stroke disorders. He
postulated that one day, surgeons may be able to
remove the “offending plaque.” He also explained
the mechanism of stroke in atrial brillation (cardioembolic). Egas Moniz from Portugal developed cerebral angiography making it possible to
visualize the extracranial arteries and the intracranial vascular system. By late 1940s and early
1950s, the medical community became aware of
the signicance of carotid disease, there was
angiography to conrm and visualize the disease,
but there was uncertainty about how to treat this.
Historically, Eastcott, Pickering, and Rob are
credited to have done the rst published carotid
surgery in Saint Mary’s Hospital in London in
1954 on a woman with carotid stenosis and TIA
[34]. It is now conrmed that a surgeon in
Argentina Raul Carrea performed in 1951 [35].
(Technically, the procedure was carotid artery
reconstruction. Michael DeBakey performed
carotid endarterectomy (CEA) in 1953, but did
not publish it till much later) (Fig.21.11) [37].
By 1980s, CEA became one of the most common procedures done in United States reaching
180,000 operations per year. Like so many other
procedures in history of medicine, the results
varied greatly from less than 3% stroke rate in
some institutions to greater than 20% in some.
This got the attention of media, causing public
uproar. That was the force behind two large NIH
sponsored studies here in US (NASCET—North
American Symptomatic Carotid Endarterectomy
Trial and ACAS—Atherosclerosis Carotid
Artery Study) and almost similar study in Europe
[38]. The conclusion of all three trials indicated

254
Fig. 21.11 Carotid endarterectomy techniques—historical perspective
I. A. Laskowski et al.
that CEA is indicated in symptomatic patients a
with hemodynamically signicant carotid stenosis, provided the operation is performed with
combined stroke and mortality rates of 3–5%.
The neurologic community and surgeons were
now held to a high standard of care, very much
similar to cardiac surgeons doing CABG and
transplant surgeons doing kidney transplantation. This was the beginning of accountability
and a sort of code of conduct for the surgeons
which also standardized the management of
carotid disease—screening, diagnosis, indications, and expected outcomes.
The Operation
Carotid endarterectomy is a procedure which
requires high technical skill as well as an understanding of brain physiology. This is an operation
that has to be done technically perfect and physiologically right. The surgical team concept where
every individual has the assigned role including
the anesthesiologist, neuromonitoring personnel,
circulating and the scrub nurse, the surgeon and
his assistant—all doing work in synchrony. The
postoperative care is as important as the surgery
itself. Creation of clinical pathway (Carotid pathway) further streamlines the postoperative care
by the PACU nurses who are knowledgeable
about certain unique features of carotid surgery.
For instance, hypotension calls for starting a
pressor and not uid bolus (as required in almost
all other surgery cases). Similarly, the nursing
staff should be aware of the signicance of neck
hematoma or hoarseness, laryngeal stridor, or
new neurologic decit, all of which require escalation of care and urgent intervention.
Regarding the conduct of surgery itself, some
pointers are worth noting. Regarding type of anesthesia, whether regional or general has been looked
at, extensively. There is no difference in outcome
between those who use general anesthesia and
those who use regional cervical block. It comes
down to individual surgeon’s preference, and the
capability of anesthesia team to give a good
regional block. Irrespective of the type of anesthesia, the conduct of operation requires, that in addition to doing a complete endarterectomy, a) there
is adequate brain perfusion at all times and b)
attention to technical steps to prevent embolization
of atheromatous debris during surgery.
Assessment of Cerebral Tolerance to Internal
Carotid Artery Clamping.

21 Surgical Decision-Making in Vascular Surgery: Practical Approaches to New Innovative Techniques…
255
Brain is a remarkable organ, weighing 2% of
the body weight, receives 15% of the cardiac output. Blood ow is 750-1000mls/minute. The normal resting ow is 50mls/100g of tissue/minute.
When brain blood ow drops to 30mls/100 g/
min., there is ischemia and reduction of ow to
20mls/100g/min or lower, thus results in cerebral
infarction. It is important to maintain adequate
ow when the internal carotid is clamped. There
are ways of assessing the safety of internal carotid
artery clamping:
1. Preoperative imaging studies—Helps to
assess contralateral carotid, vertebral arteries,
and circle of Willis. If contralateral carotid is
occluded or if there is incomplete circle of
Willis, shunting will be needed.
2. Operating on a wake patient (regional anes-
thesia)—Assessment of motor and cognitive
function with clamping (not possible if general anesthesia is used).
3. Continuous EEG monitoring, evoke poten-
tials monitoring (wave amplitude and
pattern).
4. Measurement of cerebral blood ow (very
cumbersome, not practical).
5. Measurement of stump pressure (50 mmHg
acceptable, shunt required if lower).
The procedure begins with positioning, preparation, and draping of the elds. Head should be
extended and turned away from the side of operation. It is important not to hyperextend the
neck. Elderly patient may have degenerative disease of the spine. Hyperextension in these situations may cause vascular (vertebral artery) and
nerve compression. It is important to seal the
operative area with impervious barrier to prevent
any escape of oxygen into the eld from nasal
cannula which if occurs can be a serious re hazard. The eld should be dried. Incision is oblique
along the anterior border of sternomastoid. The
external jugular vein coursing supercial to the
muscle is ligated and divided. The muscle is
retracted with retractors. Too aggressive retraction and placing the retractor blades too deep
may by itself cause stretch injury to recurrent
laryngeal nerve. The common carotid artery is
exposed rst. Some of the tributaries of IJV will
need ligation. Middle thyroid vein in the lower
part of the neck and facial vein is generally at the
level of carotid bifurcation. If nerves are seen
coursing anterior to the carotid artery, the most
common being Ansa cervicalis, gentle dissection, and retraction are preferable to transection.
Occasionally, the recurrent laryngeal nerve may
course across the common carotid (nonrecurrent
recurrent laryngeal nerve). The common carotid
artery (CCA) is dissected rst and controlled
with vessel loop. Keeping close to CCA, the dissection proceeds cephalad, external carotid
artery (ECA), and the very rst branch of it,
superior thyroid is controlled with vessel loops.
Care should be taken to avoid dissection or rough
manipulation of the carotid bulb, since this is the
area of disease and rough handling, can cause
embolization of atheromatous debris. The internal carotid artery (ICA) beyond the plaque
should be dissected and controlled. Enough
length of internal carotid should be dissected in
case shunt is needed. It is important to identify
the hypoglossal nerve which runs obliquely from
lateral to medial about two inches cephalad to
carotid bifurcation, however it can be lower.
Once CCA, ECA, and ICA controlled, the patient
is heparinized, adequacy of heparinization monitored with activated clotting time (ACT) which
should be between 230 and 270 sec. ICA is
clamped rst followed by ECA and
CCA.Arteriotomy begins in healthy CCA below
the diseased area and is extended into the bulb
on a slightly lateral location (arteriotomy too
medial on the bulb may result in distortion of the
bulb when closed and extended anteriorly in ICA
beyond the plaque). Endarterectomy is begun
after developing an appropriate plane (ideally
between the inner and outer media). The entire
plaque is removed. The arteriotomy should
extend beyond the ending of endarterectomy. No
part of the plaque should be left behind (complete endarterectomy), particularly on the internal carotid. If there is an intimal ledge, anchoring
sutures may be used to tack the area to avoid dissection when ow is restored. Endarterectomy
from ECA is done by eversion technique. All the
debris, shards, and bers are removed until the

256
I. A. Laskowski et al.
surface is smooth. The arteriotomy is closed
with either a Dacron patch or bovine pericardial
patch.
Unclamping Sequence (see diagram).
In order to prevent any embolization of particulate matter and/or air, proper unclamping
sequence should be followed. This has ve steps
[36]
STEP 1. Unclamp the ICA and allow back bleed-
ing (last few stiches are kept loose to allow
this)
STEP 2. Re-clamp the ICA at its origin
STEP 3. Unclamp the ECA and let it bleed out
STEP 4. Unclamp the CCA directing the blood to
ECA with ICA still clamped. Sutures are tied
STEP 5. Unclamp the ICA
Heparin is neutralized with protamine sulfate.
After assuring complete hemostasis, incision is
closed in layers (Fig.21.12).
Eversion Endarterectomy
This is another technique popularized by the
Albany group. In this technique, after dissection
and clamping CCA, ECA, and ICA, the internal
is transected obliquely from the carotid bulb.
Fig. 21.12 Carotid endarterectomy unclamping
sequence
After creating proper endarterectomy plane, the
ICA wall is gently rolled back (everted) to sufcient length till the endpoint of the disease and
plaque is removed. Similar maneuver is done on
the common and external carotid. After completion, the ICA is anastomosed to the bulb. The
advantages of this procedure being, no patch is
required. Disadvantage is that if the disease is
extensive, eversion is technically difcult or
inadequate. It is also harder to use a shunt if
required. Eversion endarterectomy requires experience and appropriate patient selection.
Complications
Every surgical procedure has complications, but
hazards can be disastrous and thus safeguards
during carotid endarterectomy are a must [39].
The goal is to minimize the incidence and under
ideal situation, it should reach near zero. Some of
the complications unique and specic to carotid
endarterectomy are as follows:
1. Bleeding: Bleeding can happen after any
operative procedure. When happens after
CEA, it can have catastrophic consequences.
Even moderate hematoma in the neck can
cause venous compression, which results in
laryngeal edema manifested initially by
hoarseness and stridor soon after. This is a
surgical emergency. It is important to remove
the neck staples/sutures and sutures of the
underlying layer to decompress the hematoma
by bedside in PACU while preparations are
made to return to OR.As soon as the hematoma is evacuated and the neck decompressed,
patient will immediately feel better. The grave
mistake is to attempt intubation of a patient in
respiratory distress and stridor. Because of the
laryngeal edema, the entrance to trachea will
be pinhole, the anesthesiologist will not be
able to intubate and aggressive attempts to
intubate without rst decompressing the neck
will result in increasing anxiety on part of the
patient, further anoxia and cardiac arrest.
2. Hypotension: Hypotension is seen in more
than half of patients soon after the operation.

21 Surgical Decision-Making in Vascular Surgery: Practical Approaches to New Innovative Techniques…
257
This is explained on the basis of irritability
and alteration of the carotid baroreceptors
which are a group of highly specialized cells
located at the carotid bifurcation when stimulated baroreceptors cause hypotension and
bradycardia. This is seen immediately or soon
after the patient goes to Post Anesthesia Care
Unit (PACU). It is important for the PACU
nurse and other staff to be aware of this phenomenon. Unlike all other surgical procedures, where post-operative hypotension may
indicate hypovolemia and calls for uid bolus
or blood, post-carotid endarterectomy
hypotension needs pressor agents. The most
commonly used agent is phenylephrine
(Neosynephrine) given as a drip with dose
titrated to keep systolic blood pressure around
110–129mmHg. Hypotension generally lasts
for about 4–6hours as the body’s autoregulation sets in by that time. If hypotension is not
recognized or acted upon immediately, there
is potential for the endarterectomized segment
to thrombose with disastrous consequences.
Hence the need for all CEA patients to be
monitored for 6–8hours in PACU.
3. Hypertension and Cerebral Hyper-perfusion
Syndrome: Patients who have history of
hypertension should be monitored in PACU
and also afterwards to assure good control of
blood pressure to normal range. Hypertension
may facilitate bleeding at fresh surgical site. If
that happens, measures described above
should be followed in addition to controlling
the blood pressure. In patients who had signicantly compromised blood ow before
operation (high grade stenosis of one carotid
with total occlusion of contralateral carotid),
intraoperative, peri-operative, and postoperative hypertension can lead to cerebral hyperperfusion syndrome. This is analogous to
swelling of the limb and development of compartment syndrome which occurs after restoration of blood ow in situations of acute and
profound limb ischemia. There is vasodilatation of the cerebral vascular bed in response to
severely reduced ow. After CEA, there is
sudden ooding of the brain with increased
ow and if there is element of hypertension,
this can lead to trans-vascular escape of uid,
cerebral edema, microhemorrhages and even
intracerebral hemorrhage This is a serious
complication with an incidence of about 0.5%
of carotid endarterectomy cases, resulting in
high morbidity and mortality [37]. Cerebral
hyper-perfusion syndrome can happen within
a few hours after surgery to a week or 10 days
if patient has uncontrolled hypertension.
Typically, patient complains of severe headache on the side of operation may have seizures or neurologic decits similar to stroke
[40]. Emergent CT scan, strict control of
hypertension, barbiturates, and antiseizure
drugs form the treatment strategy. Elective
CEA should be postponed in patients with
uncontrolled hypertension until their blood
pressure is appropriately treated.
4. Nerve injury: Both cranial and other nerve
injuries can happen in carotid operations4.
The hypoglossal, vagus, and glossopharyngeal nerves are in close proximity to the
artery. The recurrent laryngeal nerve is the
most common to be injured. This can happen
by excessive stretch by self-retaining retractors, or direct injury can occur by electrocautery, or transection during dissection CCA
and ECA.Hoarseness and difculty swallowing saliva can occur if there is paralysis of
ipsilateral vocal cord. This is very disabling in
addition to medicolegal implications.
Otolaryngology consult should be sought
early for proper evaluation of extent of disability and for intervention. Minor recurrent
laryngeal nerve trauma will recover in a few
weeks. The other nerve prone to injury is
hypoglossal nerve which crosses from lateral
to medial side. In most cases, it is about an
inch or two higher cephalad to the carotid
bifurcation. In some, it can cross lower, closer
to carotid bifurcation. Transection can result
in tongue deviated to the side of injury and
affects the movement of tongue and ability to
chew the food. Bilateral hypoglossal nerve
injury results in paralysis of the tongue, causing obstruction of oropharyngeal area. Patient
will require tracheostomy. Careful history
should be taken in any patient who has had

258
I. A. Laskowski et al.
CEA in the past who requires endarterectomy
on the opposite side. In cases where hypoglossal or recurrent laryngeal nerve injury appears
to have occurred, preoperative ENT evaluation is important. Injury to glossopharyngeal
is rare, since it is not generally seen during
carotid endarterectomy. However, in those
situations where the bifurcation is high, or the
disease is extensive that longer segment of
ICA needs to be exposed, care should be taken
to avoid injury to this nerve that courses anterior to ICA.Even clamp trauma to this nerve
can cause signicant pharyngeal dysfunction
causing difculty on swallowing. The recovery also is slow and some patients may require
feeding tube or even PEG for feeding for
3–5weeks which is the time it takes for the
muscles of deglutition to recover. The other
nerve prone for injury is the cervical and mandibular branch of the facial nerve. These can
be injured when the neck incision extends
higher than usual or from vigorous retraction
by self-retaining retractors when the nerve
gets compressed between the retractor blade
and the mandible causes deviation of the
angle of the mouth on the ipsilateral side. This
is a signicant complication because of cos-
metic deformity. Injury to ansa cervicalis generally does not result in any sequalae. Very
rarely, the spinal accessory nerve can be
injured (it courses across sternocleidomastoid
muscle high) resulting in difculty in raising
the shoulder. Hence it is important for the
operating surgeon to be knowledgeable of
relation of carotid artery to all the nerves and
possible anatomic variations (Fig.21.13).
5. Neurologic decit after CEA: This is perhaps
the most devastating to the patient and the surgeon. Neurologic decit immediately after
CEA is most likely due to technical factors
and warrants immediate action. If the patient
wakes up in the operating room with a neurologic decit, the incision should be opened for
direct inspection of the carotid artery. The
arteriotomy should be reopened to directly
inspect if there is an intimal ap, residual
plaque, clamp trauma or platelet thrombi, etc.,
all of which should be addressed.
Intraoperative duplex scan of the artery will
be helpful. If no technical problems noted,
then embolization of the plaque material/atheromatous debris to the brain is the most
probable cause. This calls for urgent CT to
rule out a bleed and consultation with neuro-
Fig. 21.13 Relation of nerves of the face and neck to carotid artery-surgical considerations

21 Surgical Decision-Making in Vascular Surgery: Practical Approaches to New Innovative Techniques…
259
interventional experts. They have the ability
to intervene and retrieve clot and debris from
intracranial branches of ICA.All stroke centers have neuro- intervention specialists.
Conclusion
Carotid endarterectomy has been a time-tested
operation for symptomatic carotid disease and in
select asymptomatic patients. With meticulous
attention to every detail like proper patient selection, appropriate indication, tailoring the type of
anesthesia to patient’s medical status, neuromonitoring, good surgical technique, and postoperative care by trained team guided by clinical
pathway protocols, this procedure can be performed with stroke and death rates of 1% or
lower. Acknowledging the vital importance of
teamwork and practicing it as a habit has beneted patients enormously. This indeed is testament to modern surgery.
Advanced Peripheral Arterial
Techniques forLimb Salvage: Role
ofIntravascular Lithotripsy
Introduction
Peripheral artery disease (PAD) is an important
cause of cardiovascular morbidity and mortality,
affecting over 230 million people worldwide
[41–46]. Vascular calcication is a common feature in patients with PAD, especially in the set-
ting of diabetes mellitus and/or end-stage renal
disease, leading to poor prognosis and increased
risk of major amputation. To date, limited therapeutic options are available to address severely
calcied PAD including atherectomy and cutting
balloons [42–46]. However, these devices have
not been effective in plaque modication and
vessel expansion as the presence of vascular calcication can interfere with the delivery of endovascular therapies, where it is responsible for
suboptimal vessel expansion and increased risk
of vascular complications including dissection
and perforation. Consequently, there are higher
use of provisional stents and increased risk of
suboptimal stent-related restenosis. Moreover,
although atherectomy has been shown to improve
luminal diameter and reduce the need for bailout
stenting, vascular complications such as distal
atheroembolization remain a signicant challenge [47–49].
Derived from renal lithotripsy, intravascular
lithotripsy (IVL) is a novel technique that uses
high-energy ultrasound waves to improve plaque
modication and vessel compliance (Fig. 21.14)
[50]. It uses pulsatile sonic pressure waves that
pass through soft tissue and selectively interact
strongly with high-density calcium, producing signicant shear stresses that have the ability to fracture the calcium. Furthermore, it is designed to
modify both intimal and medial calcium across a
wide range of vascular applications to increase vessel compliance, restore vessel mobility, and provide new versatile treatment options for patients.
The Shockwave Medical Peripheral IVL
System (Shockwave Medical, Fremont, CA)
Fig. 21.14 Mechanism of action of the peripheral intravascular lithotripsy. Reproduced with permission from
Shockwave Medical
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