Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:
Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_905_Библиотеки_им_академика_М_И_Перельмана.pdf
Скачиваний:
0
Добавлен:
31.08.2026
Размер:
32 Мб
Скачать
14 Surgical Decision-Making inDicult Situations inPediatric Surgery
165
there is no evidence of obstruction, shock, or peritonitis from the gangrenous bowel. Early reduction aims to prevent bowel necrosis, decrease the likelihood of testicular atrophy, and stabilize the patient.
If the incarcerated hernia cannot be reduced, or if the infant is suspected of having a strangulated inguinal hernia, then an emergency exploration is advised.
Inhaled Foreign Bodies
This is very common especially in the age group of 1 to 3 years, as toddlers are inquisitive and may ingest or inhale foreign bodies, with or with­out the knowledge of their caretaker. This may result in acute respiratory distress causing imme­diate airway compromise and the need for urgent investigation. Many times these objects are radio­lucent and may not be picked up in radiographs. However, if there is an unexplained acute respira­tory deterioration in a toddler with lung collapse or overination, emergency bronchoscopic assessment and removal of the foreign body are life-saving measures and ensure good short- and long-term prognosis.
However, if a pediatric bronchoscope is not available or pediatric surgical expertise is not available, then as a temporizing measure, the for­eign body can be advanced post carina to tide over the crisis and stabilize the patient from respiratory distress.
Ambiguous Genitalia
The birth of a baby with ambiguous genitalia presents a psychosocial emergency for the par­ents. Although immediate surgical intervention is usually not required, a thorough physical exami­nation and appropriate investigation help to assign a gender at birth. A multidisciplinary team involving a pediatric surgeon, a neonatologist, an endocrinologist, a geneticist, and a psychologist is required. The prevailing cultural environment and the existing law of the land need to be taken into consideration when caring for such babies. The age at surgery and the choice of surgery to be performed depend on multiple genetic, anatomic, psychological, and even medicolegal factors. Such decisions must be made jointly by the mul-
tidisciplinary team in the best interest of the child.
When faced with a neonate presenting with an abdominal catastrophe, several key factors are taken into account when making surgical decisions:
1. Clinical Assessment: The neonate’s clinical
condition and stability are the primary con­cern. Initial assessments include vital signs, physical examination, and laboratory tests to evaluate the severity of the condition and any associated systemic disturbances.
2. Imaging Studies: Diagnostic imaging, par-
ticularly ultrasound and radiographic stud­ies, may be used to assess the nature and extent of the abdominal pathology. These imaging studies can provide valuable infor­mation about the location and severity of the issue, aiding in surgical planning.
3. Consultation and Multidisciplinary
Approach: Neonatal abdominal catastrophes often benet from a multidisciplinary approach involving neonatologists, pediatric surgeons, radiologists, and other specialists. Collaboration ensures comprehensive evalu­ation and the development of a well-rounded treatment plan.
4. Stabilization: If the neonate’s condition is
unstable, initial measures may include resus­citation, correction of uid and electrolyte imbalances, and addressing any associated systemic complications to optimize the patient’s condition for surgery.
5. Assessment of Surgical Feasibility: The sur-
gical team evaluates the feasibility of inter­vention based on the specic pathology. Factors such as the presence of bowel isch­emia, perforation, and associated congenital anomalies are carefully considered.
6. Timing of Surgery: Timing is critical in neo-
natal abdominal catastrophes. Expedited sur­gical intervention may be necessary in cases of intestinal perforation, necrotizing entero­colitis, or strangulated hernias to prevent fur­ther deterioration. In other cases, surgical timing may depend on the neonate’s stability and the need for preoperative optimization.
166
B. S. Ratta et al.
7. Surgical Technique: The choice of surgical technique is inuenced by the underlying pathology. For example, in the case of gas­troschisis or omphalocele, the goals include a gentle reduction of bowel contents and clo­sure of the abdominal wall defect. In condi­tions such as necrotizing enterocolitis or intestinal atresia, the surgical approach may involve resection of necrotic bowel segments and anastomoses.
8. Postoperative Care Planning: Anticipating the postoperative needs of the neonate is cru­cial. This includes considerations such as ongoing monitoring, nutritional support, wound care, and potential long-term compli­cations or squeal of the surgical intervention.
9. Family Communication and Informed Consent: Open communication with the fam­ily is vital. The surgical team should provide clear and empathetic explanations of the con­dition, the proposed surgical intervention, and the potential outcomes. Informed con­sent, acknowledging the risks and benets of surgery, is an essential part of the decision­making process.
10. Ethical Considerations: In some instances, complex ethical considerations may arise, especially in situations where the prognosis is poor and the potential for long-term mor­bidity is high. The involvement of an ethics committee or consultant may be necessary to navigate these challenging scenarios. Ultimately, surgical decision-making in neo­natal abdominal catastrophes must be holistic.

Use Case 2: Rare Renal Tumors

Surgical decision-making for rare renal tumors in children involves a multidisciplinary approach and careful consideration of several factors spe­cic to the type of tumor. Rare renal tumors in children may include conditions such as Wilms’ tumor, clear cell sarcoma, malignant rhomboid tumor, renal cell carcinoma, and others.
Here is how surgical decision-making may be approached in the context of rare renal tumors in children:
1. Diagnostic Evaluation: As with any surgical
decision-making process, a thorough diag­nostic evaluation is crucial. Imaging studies, such as ultrasound, CT scans, and MRI, help in characterizing the tumor size, location, and extent of local invasion. Biopsy may be considered in cases of diagnostic uncertainty.
2. Tumor Biology and Aggressiveness:
Understanding the specic biology and aggressiveness of the rare renal tumor is par­amount. Some tumors may be more aggres­sive and require more immediate surgical intervention, while others may necessitate a more nuanced approach based on their behavior and potential for metastasis.
3. Staging and Risk Stratication: Tumor stag-
ing and risk stratication play vital roles in determining the appropriate surgical approach. The extent of local disease, involvement of regional lymph nodes, and presence of distant metastases are key con­siderations in the overall treatment plan.
4. Evaluation of Metastatic Disease: In some
cases of rare renal tumors, the presence of metastatic disease may signicantly inu­ence the surgical approach. This evaluation may involve additional imaging and, in some cases, a biopsy of suspected metastatic lesions.
5. Nephrectomy vs. Nephron-Sparing Surgery:
The decision between nephrectomy and nephron-sparing surgery depends on the tumor’s size, location, and the child’s overall renal function. Preservation of renal function is a crucial consideration, especially in cases where the tumor is amenable to partial resec­tion, especially in bilateral cases.
6. Surgical Approach and Extent of Resection:
The choice of surgical approach, including open, laparoscopic, or robotic-assisted tech­niques, is inuenced by the tumor’s charac­teristics and the child’s anatomy. For
14 Surgical Decision-Making inDicult Situations inPediatric Surgery
167
aggressive tumors, achieving clear margins while minimizing the risk of tumor spillage is essential.
7. Lymph Node Assessment: In cases where regional lymph node involvement is a con­cern, the surgical team may consider lymph node sampling or dissection to accurately stage the disease and guide adjuvant treat­ment decisions.
8. Role of Adjuvant Therapy: Surgical decision­making also encompasses considerations regarding the potential role of adjuvant ther­apy, such as chemotherapy or radiation, fol­lowing surgical resection. The surgical team collaborates closely with medical and radia­tion oncologists to plan a comprehensive treatment strategy.
9. Long-Term Functional and Oncologic Outcomes: Anticipating the long-term func­tional and oncologic outcomes is critical. Close follow-up, monitoring for potential late effects of treatment, and ongoing sur­veillance for disease recurrence are integral components of the overall surgical decision­making process.
10. Psychosocial Support and Family Involvement: The surgical team works closely with the child and family, providing comprehensive psychosocial support and ensuring that the family is actively involved in shared decision- making throughout the treatment journey.
11. Research and Clinical Trials: In the context of rare renal tumors, consideration of partici­pation in clinical trials and research proto­cols may inuence surgical decision-making. Access to novel therapies and a deeper understanding of the underlying tumor biol­ogy can be facilitated through participation in collaborative research efforts.
Surgical decision-making in the context of rare renal tumors in children requires a tailored, patient-centered approach that accounts for the specic tumor biology, risk stratication, and the child’s long-term well-being. Collaboration among pediatric surgeons, urologic oncologists, pediatric oncologists, and other specialists is
essential for optimizing treatment outcomes and ensuring comprehensive care for these complex and challenging conditions.

Use Case 3: Pediatric Traumatic Amputations

Pediatric traumatic amputations present unique challenges in surgical decision-making and man­agement. When addressing pediatric traumatic amputations, several key considerations come into play:
1. Extent and Type of Amputation: The specic type and level of traumatic amputation sig­nicantly inuence surgical decision­making. Whether it involves partial foot amputation, below-knee amputation, above­knee amputation, or upper extremity amputa­tion, the anatomical site and tissue viability guide the surgical approach.
2. Vascular and Soft Tissue Assessment: Vascular and soft tissue assessment is critical to determine the adequacy of blood supply and tissue viability in the residual limb. Reconstructive options, including replanta­tion, revision amputation, and tissue cover­age procedures, depend on the condition of the residual limb and the child’s overall vas­cular status.
3. Replantation Considerations: In cases of traumatic amputation, particularly in upper extremity injuries, it is advisable to evaluate replantation. Factors such as the mechanism of injury, ischemia time, and the presence of associated injuries are carefully considered while evaluating replantation.
4. Multidisciplinary Team Collaboration: Surgical decision-making for pediatric trau­matic amputations involves multidisciplinary collaboration with orthopedic, plastic, recon­structive, and vascular surgeons and thera­pists to address the complex functional and psychosocial needs of the child.
5. Bone and Joint Integrity: The preservation of bone and joint integrity is an essential con­sideration, particularly for growing children.
168
B. S. Ratta et al.
Limb-length inequalities, joint stability, and long-term functional outcomes are carefully evaluated when planning surgical interven­tions, such as revision amputation or recon­structive procedures.
6. Functional Rehabilitation Potential: Assessing the child’s potential for functional rehabilitation and prosthetic tting plays a crucial role in surgical decision-making. Preservation of length, functional muscle units, and sensation in the residual limb are important for optimizing prosthetic out­comes and long- term functional independence.
7. Psychosocial and Developmental Impact: Recognizing the psychosocial and develop­mental impact of traumatic amputations on children is integral to surgical decision­making. Involving child life specialists, psy­chologists, and social workers is critical in addressing the emotional and developmental needs of the child and family throughout the treatment.
8. Prosthetic Considerations: Anticipating the child’s prosthetic needs and preferences inuences surgical decision-making. Creating a residual limb that is well-suited for prosthetic tting and incorporating the child’s input in the decision-making process is essential for optimizing postamputation quality of life.
9. Long-Term Follow-Up and Support: Surgical decision-making for pediatric traumatic amputations encompasses long-term follow­ up and support. Monitoring for complica­tions, addressing the child’s growth-related needs, and providing ongoing psychosocial support are integral components of postam­putation care.
10. Patient and Family-Centered Care: It is important to engage the child and family in shared decision-making. This helps in addressing their concerns and providing comprehensive education about the surgical options. This helps in managing expectations of outcomes. It is crucial to ensure patient and family-centered care throughout the treatment process.
11. Research and Innovation: Embracing ongo-
Use Case 4: Dicult Situations inPediatric Urology Arise When Dealing withComplex Conditions That Require Surgical Intervention
Several key difcult situations in pediatric urol­ogy, along with their associated challenges in surgical decision-making, include the following:
1. Multifactorial Genitourinary Anomalies: (a) Challenge: Children with multiple geni-
(b) Surgical Decision-Making: Such cases
2. Rare Congenital Anomalies: (a) Challenge: cloacal exstrophy or persistent
ing research and innovation in the eld of pediatric traumatic amputations inuences surgical decision-making. Access to novel technologies, prosthetic advancements, and participation in clinical trials contribute to advancing the care and outcomes for pedi­atric amputees. Surgical decision-making for pediatric traumatic amputations requires a comprehensive and individualized approach that considers the child’s unique physiological, anatomical, developmental, and psychosocial needs. Collaboration among multidisciplinary teams, active involvement of the child and family, and a focus on long- term functional and psycho­social outcomes are fundamental in addressing the complexities of pediatric traumatic amputations.
tourinary anomalies present a complex surgical challenge due to the need for comprehensive and integrated treatment plans.
involve a multidisciplinary team approach, considering the overall impact on genitourinary function, potential long­term complications, and the need for staged procedures.
cloaca presents unique challenges due to the scarcity of experience with similar cases and limited evidence-based guidelines.
14 Surgical Decision-Making inDicult Situations inPediatric Surgery
169
(b) Surgical Decision-Making: Rare congen-
ital anomalies require a highly individual­ized approach, with innovation, adaptation of surgical techniques, and close collaboration with a network of spe­cialized experts in the eld.
3. Bladder Exstrophy and Epispadias Complex:
(a) Challenge: This condition involves sig-
nicant surgical and reconstructive chal­lenge, impacting both anatomical and psychological aspects.
(b) Surgical Decision-Making: The multidis-
ciplinary team plays a critical role in decision-making, considering not only the surgical aspects but also the potential long-term impact on urinary continence, sexual function, and psychosocial well-being.
4. Intraoperative Complications:
(a) Challenge: Unforeseen intraoperative
complications, such as vascular injury or inadequate tissue viability, can signi­cantly affect the surgical plan and the long-term outcome.
(b) Surgical Decision-Making: Real-time
decisions in response to intraoperative complications require alternative surgical approaches, extended procedures, and prompt communication with the medical team to reduce potential adverse effects.
5. Neurogenic Bladder Dysfunction:
(a) Challenge: This condition involves bal-
ancing the need for bladder drainage and preservation of renal function, often com­plicated by associated neurological issues.
(b) Surgical Decision-Making: Regarding
operative interventions or conservative management, it involves careful consider­ation of the child’s neurological status, renal function, potential for bladder reconstruction, and long-term impact on quality of life.
Complex Congenital Anomalies
Children with complex or rare congenital anoma­lies, such as craniofacial malformations, congen­ital diaphragmatic hernia, or imperforate anus,
present intricate surgical challenges. Decision­making involves the coordination of multidisci­plinary teams, including pediatric surgeons, neonatologists, anesthesiologists, geneticists, and other specialists, to create comprehensive treatment plans tailored to the individual child’s needs.
Surgical decision-making in these cases requires considering long-term functional and cosmetic outcomes, the potential for staged inter­ventions, and careful management of periopera­tive risks.
These diverse use cases reect the breadth of challenges encountered in pediatric surgical decision- making, emphasizing the need for expertise, collaboration, and ethical consider­ations in optimizing outcomes for pediatric patients across the spectrum of complex clinical scenarios.
In conclusion, the use cases discussed exem­plify the intricate nature of surgical decision­making in pediatric cases, emphasizing the crucial role of comprehensive assessment, multi­disciplinary collaboration, ethical considerations, and optimizing outcomes for young patients. The challenges presented in these scenarios span a spectrum of congenital anomalies, oncological conditions, traumatic injuries, and complex sur­gical pathologies, highlighting the diverse and ever-evolving landscape of pediatric surgical care.
One resounding theme across these use cases is the imperative of meticulous preoperative eval­uation, advanced imaging, and detailed surgical planning to address the unique anatomical con­siderations and physiological fragility of pediat­ric patients. Understanding the intricacies of neonatal and pediatric physiology is essential in navigating complex surgical interventions ensur­ing optimal outcomes while minimizing the risk of complication.
Furthermore, these use cases emphasize the importance of multidisciplinary collaboration, wherein pediatric surgeons work closely with pediatric anesthesiologists, neonatologists, pedi­atric oncologists, pediatric intensivists, and other sub-specialists to formulate comprehensive treat­ment plans. The synergy between surgical exper-
170
B. S. Ratta et al.
tise and multidisciplinary input is fundamental in addressing the holistic needs of pediatric patients, particularly in cases involving complex congeni­tal anomalies, oncological resection, and long­term surgical management.
Ethical considerations permeate every aspect of pediatric surgical decision-making, encompassing discussions on informed consent, family- centered care, and the pursuit of patient­centered outcomes. The ethical dimensions of pediatric surgery are particularly pronounced in cases involving rare congenital anomalies, end­of-life decision-making, and complex surgical interventions with the potential for long-term impact on a child’s quality of life.
Moreover, these use cases shed light on the evolving landscape of pediatric surgical innova­tions, including minimally invasive techniques, advancements in neonatal surgical care, and the integration of cutting-edge technologies into pediatric surgical practice. As the eld of pediat­ric surgery continues to progress, embracing these innovations while upholding the highest standards of safety and efcacy becomes para­mount in ensuring the best possible outcomes for young patients.
The cases highlighted in this discussion also showcase the signicance of ongoing research, education, and training in pediatric surgical decision- making. Continuous efforts to advance the understanding of pediatric surgical patholo­gies, rene surgical techniques, and disseminate best practices are vital in equipping pediatric sur-
geons with the knowledge and skills necessary to navigate the complexities of challenging clinical scenarios.
Finally, these use cases serve as a testament to the resilience and unwavering dedication of sur­gical teams in confronting the most formidable challenges in caring for pediatric patients. The commitment to optimizing long-term quality of life, providing compassionate family-centered care, and pushing the boundaries of surgical innovation exemplies the extraordinary pursuit of excellence in pediatric surgery.

Suggested Readings

Almond PS, etal. Principles and practice of pediatric sur-
gery. Lippincott Williams & Wilkins; 2012. Caty MG, Azizkhan RG, Lillehei CW.Pediatric surgery.
2-volume set. Saunders; 2011. Holcomb GW, etal. Ashcraft’s pediatric surgery. 6th ed.
Elsevier; 2019. Hollier L, Schwartz MR, Caldamone A, editors. Pediatric
surgery. 7th ed. Elsevier; 2020. Karp N. Ethical decision making in pediatric surgical
practice. Oxford University Press; 2021. Levitt MA, Peña A.Handbook of pediatric surgical patient
care. Springer; 2017. Mattei P.Pediatric surgical decision making. In: Pediatric
surgery. Cham: Springer; 2019. Oldham KT, Colombani PM, Foglia RP.Surgery of infants
and children: scientic principles and practice. 7th ed.
Elsevier; 2012. St. Peter SD, Snyder CL, Ostlie DJ.Textbook of pediatric
surgical oncology. Springer; 2018. Zamzow E.Core curriculum for neonatal intensive care
nursing. Elsevier Health Sciences; 2018.

Surgical Decision-Making: Melanoma

RondiKaumann andCameronSchlegel
15

Introduction

The care of the melanoma patient has evolved considerably over the last 10years. Improvements in systemic therapies have paved the way for dis­cussions about whether and when to de-escalate surgical intervention. Single-agent and dual­agent immunotherapies are widely used in the adjuvant setting and have a high response rate and good long-term survival [1]. The develop­ment of targeted therapies for patients with tumors exhibiting specic mutations offers yet another strategy to downstage locally advanced disease or improve survival in patients with meta­static disease [2, 3]. As systemic therapies have improved long-term survival in patients with melanoma, the complexity around surgical decision- making has increased. Surgical excision of localized and locoregional disease remains the optimal strategy for cure, and resection of meta­static disease has a growing role in select patients. Against this backdrop, the experience, judgment, and decision-making of the surgeon play a piv­otal role in the multidisciplinary care of the patient with melanoma.
R. Kauffmann (*) · C. Schlegel Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University Medical Center, Nashville, TN, USA e-mail: rondi.kauffmann@vumc.org;
cameron.schlegel@vumc.org

Preoperative Decision-Making

The Role ofSentinel Lymph Node Biopsy
Immunotherapy has revolutionized the way mel­anoma is treated. Its role in the perioperative set­ting is rapidly evolving and thus must be considered in operative planning. Ipilimumab is a human antibody against CTLA 4 that improves overall survival in Stage III high-risk melanoma patients and is the rst approved immunotherapy for melanoma [4]. Subsequently, multiple other agents have been found to improve recurrence­free survival for Stage III/IV melanoma patients, including PD-1 inhibitors nivolumab (approved in 2017) and pembrolizumab (approved in 2019), as well as BRAF/MEK-targeted therapy (dab­rafenib and trametinib, approved in 2018) [57].
With data supporting the role of immunother­apy in advanced-stage melanoma, natural ques­tions have arisen to its role in earlier-stage melanoma patients. Patients with Stage IIB/C disease have similar prevalence to those patients with Stage III disease but a greater risk of recur­rence and melanoma-specic death when com­pared to Stage IIIA patients, closely mirroring the trajectory of Stage IIIB patients [8, 9]. Keynote 716 was published in 2022 and evalu­ated the role of immunotherapy in patients with Stage IIB/C disease. The addition of adjuvant pembrolizumab signicantly reduced the risk of disease or death in Stage IIB/C patients when
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2024 R. Lati (ed.), Surgical Decision-Making, https://doi.org/10.1007/978-3-031-67391-7_15
171
172
R. Kaumann and C. Schlegel
compared to placebo alone [9]. CheckMate 76K was published shortly thereafter, demonstrating improvement in recurrence-free survival with nivolumab adjuvant treatment in Stage IIB/C patients, with a 58% reduction in risk of death or disease recurrence in patients treated with nivolumab vs placebo [10].
Given the potential role of immunotherapy in earlier, non-lymph node-positive disease, the role of sentinel lymph node biopsy in these patients with thicker melanomas has been called to ques­tion and remains under active discussion [11]. Arguments in favor of sentinel lymph node biopsy include its prognostic impact, locore­gional control, adjuvant therapy options, and consideration of immunotherapy tolerance. Thus, all patients should be discussed and considered by a multidisciplinary team.
Sentinel lymph node biopsies may signi­cantly inform patient conversation and potential immunotherapy decisions. In a recent paper using SEER data to model estimated 5-year melanoma­specic risk, the inclusion of sentinel lymph node biopsy in Stage IIB/C melanoma patients improved adjuvant therapy decision-making [12]. When considering adjuvant therapy, certain agents, specically BRAF/MEK inhibitors, remain approved only for Stage III disease, and thus completion of lymph node staging in this patient population remains crucial [7].
Patient factors, including their ability to undergo surgical therapy and subsequent immu­notherapy, must be considered in a multidisci­plinary discussion prior to proceeding with surgical therapy. Lymph node biopsy is often per­formed under general anesthesia and adds time to the procedure, particularly in high-risk or elderly patients. In addition, there is a range of tolerance of immunotherapy depending on agent(s) and duration, with grades 3 and 4 adverse events ranging from 10% to 16% in the previous quoted Stage IIB/C data [9, 10]. Multi-disciplinary dis­cussion prior to operative intervention is impor­tant, and consideration of sentinel lymph onde biopsy may be adjusted by patient frailty, co-morbidities that may predict poor systemic therapy tolerance, or those who are not interested in systemic therapy. Improvement in locore-
gional control is an additional consideration, par­ticularly in patients who may not be candidates for further systemic therapy.
Options fortheBad Operative Candidate
A diagnosis of cancer in an elderly patient pres­ents a unique challenge to the surgeon. Not only do patients in this population have a higher likeli­hood of presenting with multiple other comorbid medical conditions that render them more fragile and complex, but they are also more likely to have lower health literacy and higher rates of depression [13]. Discussions regarding quality of life and not just quantity of life should be a prior­ity for all patients who are faced with undergoing cancer treatment but are particularly important for elderly patients for whom life expectancy at baseline is shorter than their younger counter­parts. Goals of care including cure, minimizing toxicities, and feeling well enough to participate in activities of daily living (ADLs) should be dened early [14, 15]. In some cases, this discus­sion may lead to a decision for nonoperative management, or less aggressive surgical manage­ment. For patients who are poor operative candi­dates or wish to avoid surgery for other reasons and have early-stage melanoma (melanoma in situ or T1aN0 invasive), data supports the use of Mohs micrographic surgery as an alternative to standard wide local excision with a slight sur­vival advantage for Mohs micrographic surgery in a retrospective study using the National Database [16]. Older patients often have less physiologic reserve and can be expected to respond to surgery differently than younger patients and require longer recovery time. Thus, while standard of care stipulates the performance of sentinel node biopsy for invasive melanomas >1.01mm in depth, the surgeon should carefully consider the risks and benets of sentinel node biopsy in elderly patients with melanoma. It has been observed that sentinel node involvement by melanoma is less common in elderly patients, even those with thick melanomas, which may be due to atrophy of dermal lymphatic channels in
15 Surgical Decision-Making: Melanoma
Table 15.1 For older adults, geriatric assessment reduces cancer treatment side effects
Components of a geriatric assessment Domain Example Physical performance ·Assess balance, gait speed, and strength Functional status ·Assess difculty with activities such as bathing, dressing, and eating Comorbidities ·Assess the presence of other illnesses, as well as hearing and visual impairments Cognition ·Assess orientation, memory, and concentration Nutrition ·Assess weight and change in weight over 6months Social support ·Assess the presence of social support in activities of daily living when needed Polypharmacy ·Assess the number of regularly scheduled medications and high-risk medications Psychological status ·Assess depression and anxiety
Was originally published by the National Cancer Institute (https://www.cancer.gov/news- events/cancer- currents-
blog/2021/cancer- geriatric- assessment- fewer- side- effects)
173
older patients [17]. Assessment of overall patient condition relative to comorbidities using a health measurement tool such as the Karnofsky perfor­mance status can help the surgeon decide whether performance of sentinel node biopsy, which usually requires spinal or general anesthesia, is worth the additional surgical and anesthetic risk relative to primary wide local excision alone [18]. It is interesting to note that the pivotal trial upon which the use of sentinel node biopsy is based (MSLT-1) excluded patients aged >75years [19]. Despite this, other studies have shown the utility and feasibility in elderly patients [20]. For elderly patients who proceed with surgery, care­ful planning to minimize time in the hospital, addressing the risk of sundowning, ease of trans­portation burdens, and ensuring adequate assis­tance postoperatively are vital [14].
Upon initial pre-surgical evaluation of an elderly patient with melanoma, it is important to assess the chronologic vs. physiologic age of the patient. Recognizing that age is just a number and a healthy 85-year-old may tolerate surgery and systemic therapy better than a 55-year-old with multiple comorbidities, this preoperative evaluation provides important information about comorbidities, medication use, and ability to per­form activities of daily living. In the adjuvant set­ting, an ongoing multidisciplinary discussion about treatment plans is imperative. Many clini­cal trials exclude patients with signicant comor­bidities or older age [21]. Because elderly patients with cancer are also more likely to have accumu­lated comorbidities, the optimal doses of treat­ments or expected side effects are not necessarily
known in this population [22]. Results from a clinical trial showed that use of a formal geriatric assessment is an important component of multi­disciplinary cancer treatment planning [23]. This is a health measurement tool for elderly patients, which provides clinicians with information that can be used to guide treatment choices for elderly patients with advanced cancer. In that trial, patients whose care was informed by the geriatric assessment experienced fewer side effects of treatment and were less likely to experience falls during the course of their cancer treatment. While there were no differences in survival between the intervention and nonintervention arms, the reduced side effects and risk of falls would be expected to be associated with improved quality of life. While the tool was evaluated in the con­text of a medical oncology treatment plan, it has clear utility for surgeons as well. The compo­nents of the geriatric assessment are shown below, with the full assessment accessible in the publication of the original trial (Table15.1) [23].

Intraoperative Challenges

The Non-mapping Sentinel LymphNode
The use of dual tracer technique has signicantly improved the accuracy and consistency of senti­nel lymph node biopsies. Success rates of lym­phoscintigraphy to identify sentinel lymph nodes is estimated to be around 95% [19, 24]. This is higher in patients with extremity melanomas
174
R. Kaumann and C. Schlegel
(95.3% in the axilla, 99.3% in the groin) but sig­nicantly lower for mapping of the head and neck, with rates of sentinel node identication as low as 84.5% [19]. A variety of factors should be considered when this is encountered.
One variable is the frequency and volume of lymphoscintigrams performed at an institution. Like many procedures, these injections and map­ping come with a learning curve, with signicant improvements in accuracy with increasing vol­umes. Morton etal. found the rate of false nega­tives was 10.3% during their rst 25 cases, falling to 5.2% afterward [19]. Ensuring adequate train­ing and volume to improve lymphoscintigram accuracy should be considered when planning these cases.
Despite adequate training, we know that the surgeon will encounter scenarios where no senti­nel lymph node is identied on initial lymphos­cintigram. SPECT/CT has been shown to increase the identication of sentinel lymph nodes, with detection rates by SPECT/CT averaging 98.28%, compared to 95% for planar lymphoscintigraphy [24]. Additional nodal basins are identied by SPECT/CT in 17.87–38.1% of patients compared to planar lymphoscintigraphy alone [24, 25]. Surgeons also felt that the addition of SPECT/CT changed the location and shortened the length of incision in 16–81% and 6–45% of patients, respectively [25]. While time and resources must also be considered when ordering these preopera­tive tests, if access to a SPECT/CT is available, it may signicantly increase node identication and can be of particular use for head and neck melanomas.
Melanoma staging and previous perioperative treatment discussions must also be taken into account when no sentinel lymph node is identi­ed. In patients with Stage IIB/C tumors where immunotherapy may already play a role in peri­operative treatment, as previously discussed, consideration of medical oncology referral if not already complete, staging imaging, and close sur­veillance should be considered. All patients should undergo close lymph node basin monitor­ing, and integrating ultrasound surveillance in non-mapping patients should be considered on a case-by-case basis.
Challenges inMelanoma Excision: TheClosure
While much of our consideration of melanoma excision focuses on the removal and margin sta­tus of the melanoma itself, equally important and complex is the consideration of closure. While one should try to anticipate challenges with clo­sure as often as possible preoperatively with a multidisciplinary team, intraoperative situations arise in which previous closure plans must change based on tissue and size of defect.
Janis etal. described the concept of a recon­structive ladder (Fig.15.1). Rather than a specic sequence of closure options, this provides a framework to review the possibilities surgeons may consider when faced with a challenging clo­sure [26, 27]. If primary closure cannot be achieved, a temporary wound dressing or perma­nent secondary intention closure may be an option. Considerations should include whether wound contracture will cause signicant morbid­ity or movement limitations, as in adjacent or overlying a joint, as well as scarring and long­term cosmesis. Delayed reconstruction, in any form, is an option when the surgeon nds them­selves without reconstructive help and may be a preferred option for certain melanomas to con­rm clearance of margins. This is particularly true for locally recurrent or thicker lesions, mela­noma in situ with ill-dened borders, and desmo­plastic melanomas at higher risk of positive margins [27].
Skin grafts are an excellent option for recon­struction to allow for easy surveillance without signicant tissue rearrangement. Split-thickness skin grafts (STSG) are shallow skin harvests that can be meshed and placed in a variety of loca­tions. In some locations such as over joints where primary closure may appear possible, if this sig­nicantly limited the mobility of a joint, grafts may be another option to consider. Full-thickness skin grafts are alternatives to split-thickness, including the entirety of the dermis down to sub­cutaneous tissues. These grafts undergoing less secondary contraction compared to STSG but have a higher risk of complete or partial failure [28].