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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_905_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Foreword
- •Preface
- •Prologue to First Edition
- •Prologue to Second Edition
- •Further Reading
- •Contents
- •Introduction
- •Editor and Contributors
- •About the Editor
- •Contributors
- •References
- •Conclusion
- •3: Surgical Decision-Making: More Questions than Answers?
- •Introduction
- •Intraoperative Decision-Making
- •Overlooked Behaviors Impacting Surgical Decision-making Outcomes
- •The Never Event
- •Conclusion
- •References
- •Introduction
- •Personality Characteristics
- •Conclusion
- •References
- •Introduction
- •Primum Non Nocere
- •The Never Event
- •Sleep
- •Conclusion
- •References
- •Introduction
- •Situation Awareness, Perception, Comprehension, Projection
- •Conclusion
- •References
- •Introduction
- •Augmented Reality During Surgery
- •Overall Surgical Complications
- •Surgical Risk Models
- •The MySurgeryRisk Platform
- •Sepsis
- •Pancreatic Fistula
- •Hepatic Surgery
- •Transplant
- •Frailty
- •Disposition
- •Anesthesia
- •Pain Management
- •Cancer Treatment
- •Gastric Cancer
- •Detecting Preinvasive Occult Pancreatic Ductal Adenocarcinoma
- •Colorectal Cancer
- •Conclusions
- •References
- •Technological Adjuncts
- •Perioperative Monitoring
- •Functional Coagulation Assay Driven Resuscitation
- •Acute Kidney Injury
- •Extracorporeal Membrane Oxygenation
- •Bedside Laparotomy
- •Nutritional Considerations
- •Patient Centered Care Goals
- •Summary
- •References
- •Postinjury Multiple Organ Failure (MOF)
- •Decision-Making Around Interventions
- •Interventional Radiology
- •Surgery
- •Decision-Making Around Surgical Critical Care
- •Pulmonary
- •Cardiac
- •Renal
- •Hepatic
- •References
- •Introduction
- •Postoperative Complications Requiring Reoperation
- •Infection Complications: Source Control
- •Missed Enterotomies
- •Summary
- •References
- •Introduction
- •Postoperative Enterocutaneous Fistulas
- •Summary
- •Necrotizing Soft Tissue Infections
- •Postoperative Necrotizing Soft Tissue Infections (NSTIs)
- •The Management
- •Summary
- •Intestinal Ischemia
- •Summary
- •Open Cholecystectomy
- •Summary
- •The Burst Abdomen
- •The Management
- •Summary
- •References
- •Introduction
- •Hemostatic Resuscitation: Damage Control Resuscitation (DCR)
- •System-Based Damage Control Surgery
- •Damage Control Laparotomy
- •Summary
- •References
- •Introduction
- •The Component Separation Techniques
- •Onlay Placement
- •Underlay Placement
- •Bridge Mesh Placement
- •Summary
- •References
- •Introduction
- •The Medically Complex Pediatric Surgical Patient
- •Testicular Torsion
- •Midgut Volvulus
- •Trauma
- •Ileocolic Intussusception
- •Use Cases
- •Use Case 1: Neonatal Abdominal Catastrophes
- •Anorectal Malformations
- •Myelomeningocele
- •Intestinal Atresia
- •Complicated Appendicitis (Abscess or Phlegmon Formation)
- •Complicated Inguinal Hernias
- •Inhaled Foreign Bodies
- •Ambiguous Genitalia
- •Use Case 2: Rare Renal Tumors
- •Use Case 3: Pediatric Traumatic Amputations
- •Complex Congenital Anomalies
- •Suggested Readings
- •15: Surgical Decision-Making: Melanoma
- •Introduction
- •Preoperative Decision-Making
- •Intraoperative Challenges
- •Challenging Referrals
- •Sentinel Node Biopsy After Previous Excision
- •References
- •Laparoscopic Banding
- •Band Slippage
- •Pouch Enlargement
- •Band Erosion/Perforation
- •Port Complications
- •Laparoscopic Sleeve Gastrectomy
- •Bleeding
- •Leak
- •Stenosis
- •Gastric Bypass
- •Intro
- •Early Complications
- •Bleeding
- •Leak
- •Inaccurate Construction
- •Late Complications
- •Small Bowel Obstruction
- •Stenosis
- •Fistula
- •References
- •Introduction
- •Multidisciplinary Team Meeting
- •Preoperative
- •Intraoperative
- •Postoperative
- •Case 1
- •Case 2
- •Case 3
- •Case 4
- •References
- •Introduction
- •Acute Pancreatitis
- •Diagnosis
- •Gallstone pancreatitis
- •Hemorrhagic Complications
- •The Pregnant Patient
- •Choledocholithiasis
- •Intraoperative Conduct
- •Common Bile Duct Injury
- •Pancreatic Trauma
- •Surgical Options
- •Post-Surgical Care
- •Liver Trauma
- •Hepatic Injury Grading
- •Management Options
- •Conclusion
- •References
- •Introduction
- •The Decision-Making Process
- •Conclusions
- •References
- •Background
- •Ostomy Surgery
- •Colon Cancer
- •Rectal Cancer
- •Colonic Stenting
- •References
- •Introduction
- •Imaging: CTA, MRI, TEE
- •Morphologic Aortic Assessment
- •Technique
- •Introduction
- •The Operation
- •Eversion Endarterectomy
- •Complications
- •Conclusion
- •Introduction
- •Procedural Steps
- •Conclusion
- •The May–Thurner Syndrome
- •Anatomy
- •Clinical Presentation
- •Imaging Studies
- •Conservative Treatment
- •Conclusions
- •Management After Access Is Created
- •References
- •Sect. 1: Introduction
- •Sect. 2: Modern Management of Acute Aortic Dissection
- •Sect. 3. Carotid Endarterectomy—Can We Make a Good Operation Better? Technical Considereations
- •Sect. 4: Use of Advanced Peripheral Arterial Techniques for Limb Salvage: Role of Intravascular Lithotripsy
- •Sect. 5. The May–Thurner Syndrome
- •Sect. 6: Evaluation of a Patient for Hemodialysis Access
- •Sect. 7: Summary and Future of Vascular Surgery
- •Introduction
- •Primary Survey
- •Airway
- •Breathing
- •Circulation
- •Disability
- •Exposure/Environment
- •Management priorities
- •Damage Control Resuscitation (DCR)
- •Traumatic Brain Injury (TBI)
- •Abdominal Injuries
- •Damage Control Laparotomy
- •Non-operative management
- •Thoracic Injuries
- •Orthopedic Management
- •Prophylactic Antibiotics
- •Multidisciplinary Care
- •Team Collaboration
- •Sugested Readings
- •Introduction
- •General Remarks
- •Emergency Management
- •Evaluation
- •Management
- •Antimicrobial Therapy
- •Dental Hard Tissues
- •Endodontium
- •Periodontium
- •Alveolar Bone
- •Substance-Saving Restorations
- •Interdisciplinary coNcept
- •Post-initial Treatment
- •Conclusions
- •References
- •Expected vs. Unexpected Deaths
- •Second Victim Syndrome
- •Guilt
- •Acceptance
- •Burnout
- •Conclusions
- •References
- •What Is Burnout?
- •At Risk Population
- •Burnout vs. Stress
- •Measuring Tools
- •Causes
- •Burnout Prevention
- •Recovering
- •Conclusion
- •References
- •References
- •Introduction
- •Conclusion
- •References
- •Further Readings
- •Introduction
- •References
- •Index

14 Surgical Decision-Making inDicult Situations inPediatric Surgery
165
there is no evidence of obstruction, shock, or
peritonitis from the gangrenous bowel. Early
reduction aims to prevent bowel necrosis,
decrease the likelihood of testicular atrophy, and
stabilize the patient.
If the incarcerated hernia cannot be reduced,
or if the infant is suspected of having a
strangulated inguinal hernia, then an emergency
exploration is advised.
Inhaled Foreign Bodies
This is very common especially in the age group
of 1 to 3 years, as toddlers are inquisitive and
may ingest or inhale foreign bodies, with or without the knowledge of their caretaker. This may
result in acute respiratory distress causing immediate airway compromise and the need for urgent
investigation. Many times these objects are radiolucent and may not be picked up in radiographs.
However, if there is an unexplained acute respiratory deterioration in a toddler with lung collapse
or overination, emergency bronchoscopic
assessment and removal of the foreign body are
life-saving measures and ensure good short- and
long-term prognosis.
However, if a pediatric bronchoscope is not
available or pediatric surgical expertise is not
available, then as a temporizing measure, the foreign body can be advanced post carina to tide
over the crisis and stabilize the patient from
respiratory distress.
Ambiguous Genitalia
The birth of a baby with ambiguous genitalia
presents a psychosocial emergency for the parents. Although immediate surgical intervention is
usually not required, a thorough physical examination and appropriate investigation help to
assign a gender at birth. A multidisciplinary team
involving a pediatric surgeon, a neonatologist, an
endocrinologist, a geneticist, and a psychologist
is required. The prevailing cultural environment
and the existing law of the land need to be taken
into consideration when caring for such babies.
The age at surgery and the choice of surgery to be
performed depend on multiple genetic, anatomic,
psychological, and even medicolegal factors.
Such decisions must be made jointly by the mul-
tidisciplinary team in the best interest of the
child.
When faced with a neonate presenting with an
abdominal catastrophe, several key factors are
taken into account when making surgical
decisions:
1. Clinical Assessment: The neonate’s clinical
condition and stability are the primary concern. Initial assessments include vital signs,
physical examination, and laboratory tests to
evaluate the severity of the condition and any
associated systemic disturbances.
2. Imaging Studies: Diagnostic imaging, par-
ticularly ultrasound and radiographic studies, may be used to assess the nature and
extent of the abdominal pathology. These
imaging studies can provide valuable information about the location and severity of the
issue, aiding in surgical planning.
3. Consultation and Multidisciplinary
Approach: Neonatal abdominal catastrophes
often benet from a multidisciplinary
approach involving neonatologists, pediatric
surgeons, radiologists, and other specialists.
Collaboration ensures comprehensive evaluation and the development of a well-rounded
treatment plan.
4. Stabilization: If the neonate’s condition is
unstable, initial measures may include resuscitation, correction of uid and electrolyte
imbalances, and addressing any associated
systemic complications to optimize the
patient’s condition for surgery.
5. Assessment of Surgical Feasibility: The sur-
gical team evaluates the feasibility of intervention based on the specic pathology.
Factors such as the presence of bowel ischemia, perforation, and associated congenital
anomalies are carefully considered.
6. Timing of Surgery: Timing is critical in neo-
natal abdominal catastrophes. Expedited surgical intervention may be necessary in cases
of intestinal perforation, necrotizing enterocolitis, or strangulated hernias to prevent further deterioration. In other cases, surgical
timing may depend on the neonate’s stability
and the need for preoperative optimization.

166
B. S. Ratta et al.
7. Surgical Technique: The choice of surgical
technique is inuenced by the underlying
pathology. For example, in the case of gastroschisis or omphalocele, the goals include
a gentle reduction of bowel contents and closure of the abdominal wall defect. In conditions such as necrotizing enterocolitis or
intestinal atresia, the surgical approach may
involve resection of necrotic bowel segments
and anastomoses.
8. Postoperative Care Planning: Anticipating
the postoperative needs of the neonate is crucial. This includes considerations such as
ongoing monitoring, nutritional support,
wound care, and potential long-term complications or squeal of the surgical
intervention.
9. Family Communication and Informed
Consent: Open communication with the family is vital. The surgical team should provide
clear and empathetic explanations of the condition, the proposed surgical intervention,
and the potential outcomes. Informed consent, acknowledging the risks and benets of
surgery, is an essential part of the decisionmaking process.
10. Ethical Considerations: In some instances,
complex ethical considerations may arise,
especially in situations where the prognosis
is poor and the potential for long-term morbidity is high. The involvement of an ethics
committee or consultant may be necessary to
navigate these challenging scenarios.
Ultimately, surgical decision-making in neonatal abdominal catastrophes must be
holistic.
Use Case 2: Rare Renal Tumors
Surgical decision-making for rare renal tumors in
children involves a multidisciplinary approach
and careful consideration of several factors specic to the type of tumor. Rare renal tumors in
children may include conditions such as Wilms’
tumor, clear cell sarcoma, malignant rhomboid
tumor, renal cell carcinoma, and others.
Here is how surgical decision-making may be
approached in the context of rare renal tumors in
children:
1. Diagnostic Evaluation: As with any surgical
decision-making process, a thorough diagnostic evaluation is crucial. Imaging studies,
such as ultrasound, CT scans, and MRI, help
in characterizing the tumor size, location,
and extent of local invasion. Biopsy may be
considered in cases of diagnostic
uncertainty.
2. Tumor Biology and Aggressiveness:
Understanding the specic biology and
aggressiveness of the rare renal tumor is paramount. Some tumors may be more aggressive and require more immediate surgical
intervention, while others may necessitate a
more nuanced approach based on their
behavior and potential for metastasis.
3. Staging and Risk Stratication: Tumor stag-
ing and risk stratication play vital roles in
determining the appropriate surgical
approach. The extent of local disease,
involvement of regional lymph nodes, and
presence of distant metastases are key considerations in the overall treatment plan.
4. Evaluation of Metastatic Disease: In some
cases of rare renal tumors, the presence of
metastatic disease may signicantly inuence the surgical approach. This evaluation
may involve additional imaging and, in some
cases, a biopsy of suspected metastatic
lesions.
5. Nephrectomy vs. Nephron-Sparing Surgery:
The decision between nephrectomy and
nephron-sparing surgery depends on the
tumor’s size, location, and the child’s overall
renal function. Preservation of renal function
is a crucial consideration, especially in cases
where the tumor is amenable to partial resection, especially in bilateral cases.
6. Surgical Approach and Extent of Resection:
The choice of surgical approach, including
open, laparoscopic, or robotic-assisted techniques, is inuenced by the tumor’s characteristics and the child’s anatomy. For

14 Surgical Decision-Making inDicult Situations inPediatric Surgery
167
aggressive tumors, achieving clear margins
while minimizing the risk of tumor spillage
is essential.
7. Lymph Node Assessment: In cases where
regional lymph node involvement is a concern, the surgical team may consider lymph
node sampling or dissection to accurately
stage the disease and guide adjuvant treatment decisions.
8. Role of Adjuvant Therapy: Surgical decisionmaking also encompasses considerations
regarding the potential role of adjuvant therapy, such as chemotherapy or radiation, following surgical resection. The surgical team
collaborates closely with medical and radiation oncologists to plan a comprehensive
treatment strategy.
9. Long-Term Functional and Oncologic
Outcomes: Anticipating the long-term functional and oncologic outcomes is critical.
Close follow-up, monitoring for potential
late effects of treatment, and ongoing surveillance for disease recurrence are integral
components of the overall surgical decisionmaking process.
10. Psychosocial Support and Family
Involvement: The surgical team works
closely with the child and family, providing
comprehensive psychosocial support and
ensuring that the family is actively involved
in shared decision- making throughout the
treatment journey.
11. Research and Clinical Trials: In the context
of rare renal tumors, consideration of participation in clinical trials and research protocols may inuence surgical decision-making.
Access to novel therapies and a deeper
understanding of the underlying tumor biology can be facilitated through participation
in collaborative research efforts.
Surgical decision-making in the context of
rare renal tumors in children requires a tailored,
patient-centered approach that accounts for the
specic tumor biology, risk stratication, and the
child’s long-term well-being. Collaboration
among pediatric surgeons, urologic oncologists,
pediatric oncologists, and other specialists is
essential for optimizing treatment outcomes and
ensuring comprehensive care for these complex
and challenging conditions.
Use Case 3: Pediatric Traumatic Amputations
Pediatric traumatic amputations present unique
challenges in surgical decision-making and management. When addressing pediatric traumatic
amputations, several key considerations come
into play:
1. Extent and Type of Amputation: The specic
type and level of traumatic amputation signicantly inuence surgical decisionmaking. Whether it involves partial foot
amputation, below-knee amputation, aboveknee amputation, or upper extremity amputation, the anatomical site and tissue viability
guide the surgical approach.
2. Vascular and Soft Tissue Assessment:
Vascular and soft tissue assessment is critical
to determine the adequacy of blood supply
and tissue viability in the residual limb.
Reconstructive options, including replantation, revision amputation, and tissue coverage procedures, depend on the condition of
the residual limb and the child’s overall vascular status.
3. Replantation Considerations: In cases of
traumatic amputation, particularly in upper
extremity injuries, it is advisable to evaluate
replantation. Factors such as the mechanism
of injury, ischemia time, and the presence of
associated injuries are carefully considered
while evaluating replantation.
4. Multidisciplinary Team Collaboration:
Surgical decision-making for pediatric traumatic amputations involves multidisciplinary
collaboration with orthopedic, plastic, reconstructive, and vascular surgeons and therapists to address the complex functional and
psychosocial needs of the child.
5. Bone and Joint Integrity: The preservation of
bone and joint integrity is an essential consideration, particularly for growing children.

168
B. S. Ratta et al.
Limb-length inequalities, joint stability, and
long-term functional outcomes are carefully
evaluated when planning surgical interventions, such as revision amputation or reconstructive procedures.
6. Functional Rehabilitation Potential:
Assessing the child’s potential for functional
rehabilitation and prosthetic tting plays a
crucial role in surgical decision-making.
Preservation of length, functional muscle
units, and sensation in the residual limb are
important for optimizing prosthetic outcomes and long- term functional
independence.
7. Psychosocial and Developmental Impact:
Recognizing the psychosocial and developmental impact of traumatic amputations on
children is integral to surgical decisionmaking. Involving child life specialists, psychologists, and social workers is critical in
addressing the emotional and developmental
needs of the child and family throughout the
treatment.
8. Prosthetic Considerations: Anticipating the
child’s prosthetic needs and preferences
inuences surgical decision-making.
Creating a residual limb that is well-suited
for prosthetic tting and incorporating the
child’s input in the decision-making process
is essential for optimizing postamputation
quality of life.
9. Long-Term Follow-Up and Support: Surgical
decision-making for pediatric traumatic
amputations encompasses long-term follow up and support. Monitoring for complications, addressing the child’s growth-related
needs, and providing ongoing psychosocial
support are integral components of postamputation care.
10. Patient and Family-Centered Care: It is
important to engage the child and family in
shared decision-making. This helps in
addressing their concerns and providing
comprehensive education about the surgical
options. This helps in managing expectations
of outcomes. It is crucial to ensure patient
and family-centered care throughout the
treatment process.
11. Research and Innovation: Embracing ongo-
Use Case 4: Dicult Situations
inPediatric Urology Arise When
Dealing withComplex Conditions
That Require Surgical Intervention
Several key difcult situations in pediatric urology, along with their associated challenges in
surgical decision-making, include the following:
1. Multifactorial Genitourinary Anomalies:
(a) Challenge: Children with multiple geni-
(b) Surgical Decision-Making: Such cases
2. Rare Congenital Anomalies:
(a) Challenge: cloacal exstrophy or persistent
ing research and innovation in the eld of
pediatric traumatic amputations inuences
surgical decision-making. Access to novel
technologies, prosthetic advancements, and
participation in clinical trials contribute to
advancing the care and outcomes for pediatric amputees. Surgical decision-making
for pediatric traumatic amputations requires
a comprehensive and individualized
approach that considers the child’s unique
physiological, anatomical, developmental,
and psychosocial needs. Collaboration
among multidisciplinary teams, active
involvement of the child and family, and a
focus on long- term functional and psychosocial outcomes are fundamental in
addressing the complexities of pediatric
traumatic amputations.
tourinary anomalies present a complex
surgical challenge due to the need for
comprehensive and integrated treatment
plans.
involve a multidisciplinary team
approach, considering the overall impact
on genitourinary function, potential longterm complications, and the need for
staged procedures.
cloaca presents unique challenges due to
the scarcity of experience with similar
cases and limited evidence-based
guidelines.

14 Surgical Decision-Making inDicult Situations inPediatric Surgery
169
(b) Surgical Decision-Making: Rare congen-
ital anomalies require a highly individualized approach, with innovation,
adaptation of surgical techniques, and
close collaboration with a network of specialized experts in the eld.
3. Bladder Exstrophy and Epispadias Complex:
(a) Challenge: This condition involves sig-
nicant surgical and reconstructive challenge, impacting both anatomical and
psychological aspects.
(b) Surgical Decision-Making: The multidis-
ciplinary team plays a critical role in
decision-making, considering not only
the surgical aspects but also the potential
long-term impact on urinary continence,
sexual function, and psychosocial
well-being.
4. Intraoperative Complications:
(a) Challenge: Unforeseen intraoperative
complications, such as vascular injury or
inadequate tissue viability, can signicantly affect the surgical plan and the
long-term outcome.
(b) Surgical Decision-Making: Real-time
decisions in response to intraoperative
complications require alternative surgical
approaches, extended procedures, and
prompt communication with the medical
team to reduce potential adverse effects.
5. Neurogenic Bladder Dysfunction:
(a) Challenge: This condition involves bal-
ancing the need for bladder drainage and
preservation of renal function, often complicated by associated neurological
issues.
(b) Surgical Decision-Making: Regarding
operative interventions or conservative
management, it involves careful consideration of the child’s neurological status,
renal function, potential for bladder
reconstruction, and long-term impact on
quality of life.
Complex Congenital Anomalies
Children with complex or rare congenital anomalies, such as craniofacial malformations, congenital diaphragmatic hernia, or imperforate anus,
present intricate surgical challenges. Decisionmaking involves the coordination of multidisciplinary teams, including pediatric surgeons,
neonatologists, anesthesiologists, geneticists,
and other specialists, to create comprehensive
treatment plans tailored to the individual child’s
needs.
Surgical decision-making in these cases
requires considering long-term functional and
cosmetic outcomes, the potential for staged interventions, and careful management of perioperative risks.
These diverse use cases reect the breadth of
challenges encountered in pediatric surgical
decision- making, emphasizing the need for
expertise, collaboration, and ethical considerations in optimizing outcomes for pediatric
patients across the spectrum of complex clinical
scenarios.
In conclusion, the use cases discussed exemplify the intricate nature of surgical decisionmaking in pediatric cases, emphasizing the
crucial role of comprehensive assessment, multidisciplinary collaboration, ethical considerations,
and optimizing outcomes for young patients. The
challenges presented in these scenarios span a
spectrum of congenital anomalies, oncological
conditions, traumatic injuries, and complex surgical pathologies, highlighting the diverse and
ever-evolving landscape of pediatric surgical
care.
One resounding theme across these use cases
is the imperative of meticulous preoperative evaluation, advanced imaging, and detailed surgical
planning to address the unique anatomical considerations and physiological fragility of pediatric patients. Understanding the intricacies of
neonatal and pediatric physiology is essential in
navigating complex surgical interventions ensuring optimal outcomes while minimizing the risk
of complication.
Furthermore, these use cases emphasize the
importance of multidisciplinary collaboration,
wherein pediatric surgeons work closely with
pediatric anesthesiologists, neonatologists, pediatric oncologists, pediatric intensivists, and other
sub-specialists to formulate comprehensive treatment plans. The synergy between surgical exper-

170
B. S. Ratta et al.
tise and multidisciplinary input is fundamental in
addressing the holistic needs of pediatric patients,
particularly in cases involving complex congenital anomalies, oncological resection, and longterm surgical management.
Ethical considerations permeate every aspect
of pediatric surgical decision-making,
encompassing discussions on informed consent,
family- centered care, and the pursuit of patientcentered outcomes. The ethical dimensions of
pediatric surgery are particularly pronounced in
cases involving rare congenital anomalies, endof-life decision-making, and complex surgical
interventions with the potential for long-term
impact on a child’s quality of life.
Moreover, these use cases shed light on the
evolving landscape of pediatric surgical innovations, including minimally invasive techniques,
advancements in neonatal surgical care, and the
integration of cutting-edge technologies into
pediatric surgical practice. As the eld of pediatric surgery continues to progress, embracing
these innovations while upholding the highest
standards of safety and efcacy becomes paramount in ensuring the best possible outcomes for
young patients.
The cases highlighted in this discussion also
showcase the signicance of ongoing research,
education, and training in pediatric surgical
decision- making. Continuous efforts to advance
the understanding of pediatric surgical pathologies, rene surgical techniques, and disseminate
best practices are vital in equipping pediatric sur-
geons with the knowledge and skills necessary to
navigate the complexities of challenging clinical
scenarios.
Finally, these use cases serve as a testament to
the resilience and unwavering dedication of surgical teams in confronting the most formidable
challenges in caring for pediatric patients. The
commitment to optimizing long-term quality of
life, providing compassionate family-centered
care, and pushing the boundaries of surgical
innovation exemplies the extraordinary pursuit
of excellence in pediatric surgery.
Suggested Readings
Almond PS, etal. Principles and practice of pediatric sur-
gery. Lippincott Williams & Wilkins; 2012.
Caty MG, Azizkhan RG, Lillehei CW.Pediatric surgery.
2-volume set. Saunders; 2011.
Holcomb GW, etal. Ashcraft’s pediatric surgery. 6th ed.
Elsevier; 2019.
Hollier L, Schwartz MR, Caldamone A, editors. Pediatric
surgery. 7th ed. Elsevier; 2020.
Karp N. Ethical decision making in pediatric surgical
practice. Oxford University Press; 2021.
Levitt MA, Peña A.Handbook of pediatric surgical patient
care. Springer; 2017.
Mattei P.Pediatric surgical decision making. In: Pediatric
surgery. Cham: Springer; 2019.
Oldham KT, Colombani PM, Foglia RP.Surgery of infants
and children: scientic principles and practice. 7th ed.
Elsevier; 2012.
St. Peter SD, Snyder CL, Ostlie DJ.Textbook of pediatric
surgical oncology. Springer; 2018.
Zamzow E.Core curriculum for neonatal intensive care
nursing. Elsevier Health Sciences; 2018.

Surgical Decision-Making: Melanoma
RondiKaumann andCameronSchlegel
15
Introduction
The care of the melanoma patient has evolved
considerably over the last 10years. Improvements
in systemic therapies have paved the way for discussions about whether and when to de-escalate
surgical intervention. Single-agent and dualagent immunotherapies are widely used in the
adjuvant setting and have a high response rate
and good long-term survival [1]. The development of targeted therapies for patients with
tumors exhibiting specic mutations offers yet
another strategy to downstage locally advanced
disease or improve survival in patients with metastatic disease [2, 3]. As systemic therapies have
improved long-term survival in patients with
melanoma, the complexity around surgical
decision- making has increased. Surgical excision
of localized and locoregional disease remains the
optimal strategy for cure, and resection of metastatic disease has a growing role in select patients.
Against this backdrop, the experience, judgment,
and decision-making of the surgeon play a pivotal role in the multidisciplinary care of the
patient with melanoma.
R. Kauffmann (*) · C. Schlegel
Division of Surgical Oncology and Endocrine
Surgery, Vanderbilt University Medical Center,
Nashville, TN, USA
e-mail: rondi.kauffmann@vumc.org;
cameron.schlegel@vumc.org
Preoperative Decision-Making
The Role ofSentinel Lymph Node
Biopsy
Immunotherapy has revolutionized the way melanoma is treated. Its role in the perioperative setting is rapidly evolving and thus must be
considered in operative planning. Ipilimumab is a
human antibody against CTLA 4 that improves
overall survival in Stage III high-risk melanoma
patients and is the rst approved immunotherapy
for melanoma [4]. Subsequently, multiple other
agents have been found to improve recurrencefree survival for Stage III/IV melanoma patients,
including PD-1 inhibitors nivolumab (approved
in 2017) and pembrolizumab (approved in 2019),
as well as BRAF/MEK-targeted therapy (dabrafenib and trametinib, approved in 2018) [5–7].
With data supporting the role of immunotherapy in advanced-stage melanoma, natural questions have arisen to its role in earlier-stage
melanoma patients. Patients with Stage IIB/C
disease have similar prevalence to those patients
with Stage III disease but a greater risk of recurrence and melanoma-specic death when compared to Stage IIIA patients, closely mirroring
the trajectory of Stage IIIB patients [8, 9].
Keynote 716 was published in 2022 and evaluated the role of immunotherapy in patients with
Stage IIB/C disease. The addition of adjuvant
pembrolizumab signicantly reduced the risk of
disease or death in Stage IIB/C patients when
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2024
R. Lati (ed.), Surgical Decision-Making, https://doi.org/10.1007/978-3-031-67391-7_15
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R. Kaumann and C. Schlegel
compared to placebo alone [9]. CheckMate 76K
was published shortly thereafter, demonstrating
improvement in recurrence-free survival with
nivolumab adjuvant treatment in Stage IIB/C
patients, with a 58% reduction in risk of death or
disease recurrence in patients treated with
nivolumab vs placebo [10].
Given the potential role of immunotherapy in
earlier, non-lymph node-positive disease, the role
of sentinel lymph node biopsy in these patients
with thicker melanomas has been called to question and remains under active discussion [11].
Arguments in favor of sentinel lymph node
biopsy include its prognostic impact, locoregional control, adjuvant therapy options, and
consideration of immunotherapy tolerance. Thus,
all patients should be discussed and considered
by a multidisciplinary team.
Sentinel lymph node biopsies may signicantly inform patient conversation and potential
immunotherapy decisions. In a recent paper using
SEER data to model estimated 5-year melanomaspecic risk, the inclusion of sentinel lymph node
biopsy in Stage IIB/C melanoma patients
improved adjuvant therapy decision-making
[12]. When considering adjuvant therapy, certain
agents, specically BRAF/MEK inhibitors,
remain approved only for Stage III disease, and
thus completion of lymph node staging in this
patient population remains crucial [7].
Patient factors, including their ability to
undergo surgical therapy and subsequent immunotherapy, must be considered in a multidisciplinary discussion prior to proceeding with
surgical therapy. Lymph node biopsy is often performed under general anesthesia and adds time to
the procedure, particularly in high-risk or elderly
patients. In addition, there is a range of tolerance
of immunotherapy depending on agent(s) and
duration, with grades 3 and 4 adverse events
ranging from 10% to 16% in the previous quoted
Stage IIB/C data [9, 10]. Multi-disciplinary discussion prior to operative intervention is important, and consideration of sentinel lymph onde
biopsy may be adjusted by patient frailty,
co-morbidities that may predict poor systemic
therapy tolerance, or those who are not interested
in systemic therapy. Improvement in locore-
gional control is an additional consideration, particularly in patients who may not be candidates
for further systemic therapy.
Options fortheBad Operative
Candidate
A diagnosis of cancer in an elderly patient presents a unique challenge to the surgeon. Not only
do patients in this population have a higher likelihood of presenting with multiple other comorbid
medical conditions that render them more fragile
and complex, but they are also more likely to
have lower health literacy and higher rates of
depression [13]. Discussions regarding quality of
life and not just quantity of life should be a priority for all patients who are faced with undergoing
cancer treatment but are particularly important
for elderly patients for whom life expectancy at
baseline is shorter than their younger counterparts. Goals of care including cure, minimizing
toxicities, and feeling well enough to participate
in activities of daily living (ADLs) should be
dened early [14, 15]. In some cases, this discussion may lead to a decision for nonoperative
management, or less aggressive surgical management. For patients who are poor operative candidates or wish to avoid surgery for other reasons
and have early-stage melanoma (melanoma in
situ or T1aN0 invasive), data supports the use of
Mohs micrographic surgery as an alternative to
standard wide local excision with a slight survival advantage for Mohs micrographic surgery
in a retrospective study using the National
Database [16]. Older patients often have less
physiologic reserve and can be expected to
respond to surgery differently than younger
patients and require longer recovery time. Thus,
while standard of care stipulates the performance
of sentinel node biopsy for invasive melanomas
>1.01mm in depth, the surgeon should carefully
consider the risks and benets of sentinel node
biopsy in elderly patients with melanoma. It has
been observed that sentinel node involvement by
melanoma is less common in elderly patients,
even those with thick melanomas, which may be
due to atrophy of dermal lymphatic channels in

15 Surgical Decision-Making: Melanoma
Table 15.1 For older adults, geriatric assessment reduces cancer treatment side effects
Components of a geriatric assessment
Domain Example
Physical performance ·Assess balance, gait speed, and strength
Functional status ·Assess difculty with activities such as bathing, dressing, and eating
Comorbidities ·Assess the presence of other illnesses, as well as hearing and visual impairments
Cognition ·Assess orientation, memory, and concentration
Nutrition ·Assess weight and change in weight over 6months
Social support ·Assess the presence of social support in activities of daily living when needed
Polypharmacy ·Assess the number of regularly scheduled medications and high-risk medications
Psychological status ·Assess depression and anxiety
Was originally published by the National Cancer Institute (https://www.cancer.gov/news- events/cancer- currents-
blog/2021/cancer- geriatric- assessment- fewer- side- effects)
173
older patients [17]. Assessment of overall patient
condition relative to comorbidities using a health
measurement tool such as the Karnofsky performance status can help the surgeon decide whether
performance of sentinel node biopsy, which
usually requires spinal or general anesthesia, is
worth the additional surgical and anesthetic risk
relative to primary wide local excision alone
[18]. It is interesting to note that the pivotal trial
upon which the use of sentinel node biopsy is
based (MSLT-1) excluded patients aged >75years
[19]. Despite this, other studies have shown the
utility and feasibility in elderly patients [20]. For
elderly patients who proceed with surgery, careful planning to minimize time in the hospital,
addressing the risk of sundowning, ease of transportation burdens, and ensuring adequate assistance postoperatively are vital [14].
Upon initial pre-surgical evaluation of an
elderly patient with melanoma, it is important to
assess the chronologic vs. physiologic age of the
patient. Recognizing that age is just a number
and a healthy 85-year-old may tolerate surgery
and systemic therapy better than a 55-year-old
with multiple comorbidities, this preoperative
evaluation provides important information about
comorbidities, medication use, and ability to perform activities of daily living. In the adjuvant setting, an ongoing multidisciplinary discussion
about treatment plans is imperative. Many clinical trials exclude patients with signicant comorbidities or older age [21]. Because elderly patients
with cancer are also more likely to have accumulated comorbidities, the optimal doses of treatments or expected side effects are not necessarily
known in this population [22]. Results from a
clinical trial showed that use of a formal geriatric
assessment is an important component of multidisciplinary cancer treatment planning [23]. This
is a health measurement tool for elderly patients,
which provides clinicians with information that
can be used to guide treatment choices for elderly
patients with advanced cancer. In that trial,
patients whose care was informed by the geriatric
assessment experienced fewer side effects of
treatment and were less likely to experience falls
during the course of their cancer treatment. While
there were no differences in survival between the
intervention and nonintervention arms, the
reduced side effects and risk of falls would be
expected to be associated with improved quality
of life. While the tool was evaluated in the context of a medical oncology treatment plan, it has
clear utility for surgeons as well. The components of the geriatric assessment are shown
below, with the full assessment accessible in the
publication of the original trial (Table15.1) [23].
Intraoperative Challenges
The Non-mapping Sentinel
LymphNode
The use of dual tracer technique has signicantly
improved the accuracy and consistency of sentinel lymph node biopsies. Success rates of lymphoscintigraphy to identify sentinel lymph nodes
is estimated to be around 95% [19, 24]. This is
higher in patients with extremity melanomas

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R. Kaumann and C. Schlegel
(95.3% in the axilla, 99.3% in the groin) but signicantly lower for mapping of the head and
neck, with rates of sentinel node identication as
low as 84.5% [19]. A variety of factors should be
considered when this is encountered.
One variable is the frequency and volume of
lymphoscintigrams performed at an institution.
Like many procedures, these injections and mapping come with a learning curve, with signicant
improvements in accuracy with increasing volumes. Morton etal. found the rate of false negatives was 10.3% during their rst 25 cases, falling
to 5.2% afterward [19]. Ensuring adequate training and volume to improve lymphoscintigram
accuracy should be considered when planning
these cases.
Despite adequate training, we know that the
surgeon will encounter scenarios where no sentinel lymph node is identied on initial lymphoscintigram. SPECT/CT has been shown to increase
the identication of sentinel lymph nodes, with
detection rates by SPECT/CT averaging 98.28%,
compared to 95% for planar lymphoscintigraphy
[24]. Additional nodal basins are identied by
SPECT/CT in 17.87–38.1% of patients compared
to planar lymphoscintigraphy alone [24, 25].
Surgeons also felt that the addition of SPECT/CT
changed the location and shortened the length of
incision in 16–81% and 6–45% of patients,
respectively [25]. While time and resources must
also be considered when ordering these preoperative tests, if access to a SPECT/CT is available, it
may signicantly increase node identication
and can be of particular use for head and neck
melanomas.
Melanoma staging and previous perioperative
treatment discussions must also be taken into
account when no sentinel lymph node is identied. In patients with Stage IIB/C tumors where
immunotherapy may already play a role in perioperative treatment, as previously discussed,
consideration of medical oncology referral if not
already complete, staging imaging, and close surveillance should be considered. All patients
should undergo close lymph node basin monitoring, and integrating ultrasound surveillance in
non-mapping patients should be considered on a
case-by-case basis.
Challenges inMelanoma Excision:
TheClosure
While much of our consideration of melanoma
excision focuses on the removal and margin status of the melanoma itself, equally important and
complex is the consideration of closure. While
one should try to anticipate challenges with closure as often as possible preoperatively with a
multidisciplinary team, intraoperative situations
arise in which previous closure plans must change
based on tissue and size of defect.
Janis etal. described the concept of a reconstructive ladder (Fig.15.1). Rather than a specic
sequence of closure options, this provides a
framework to review the possibilities surgeons
may consider when faced with a challenging closure [26, 27]. If primary closure cannot be
achieved, a temporary wound dressing or permanent secondary intention closure may be an
option. Considerations should include whether
wound contracture will cause signicant morbidity or movement limitations, as in adjacent or
overlying a joint, as well as scarring and longterm cosmesis. Delayed reconstruction, in any
form, is an option when the surgeon nds themselves without reconstructive help and may be a
preferred option for certain melanomas to conrm clearance of margins. This is particularly
true for locally recurrent or thicker lesions, melanoma in situ with ill-dened borders, and desmoplastic melanomas at higher risk of positive
margins [27].
Skin grafts are an excellent option for reconstruction to allow for easy surveillance without
signicant tissue rearrangement. Split-thickness
skin grafts (STSG) are shallow skin harvests that
can be meshed and placed in a variety of locations. In some locations such as over joints where
primary closure may appear possible, if this signicantly limited the mobility of a joint, grafts
may be another option to consider. Full-thickness
skin grafts are alternatives to split-thickness,
including the entirety of the dermis down to subcutaneous tissues. These grafts undergoing less
secondary contraction compared to STSG but
have a higher risk of complete or partial failure
[28].
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