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- •Leukemia
- •Normal haemopoiesis
- •Hemoblastosis
- •Haemopoiesis
- •Leukemia
- •Types of leukemia
- •Classification of leukemia
- •Classification of AML
- •Pictures of blood
- •Myeloid Maturation
- •Lymphoblast/Myeloblast
- •Epidemiology of acute leukemia
- •Etiology
- •Two-hit model of leukemogenesis
- •Clinical presentation
- •Stages of acute leukemia
- •Extramedullar clinical presentation of acute leukemia
- •Leukemia cutis and chloroma
- •Gum hyperplasia
- •Diagnostics of leukemia
- •Morphological method
- •Normal bone marrow
- •Acute leukemia
- •Acute lymphoblastic leukemia
- •Hodjkin`s lymphoma
- •Immunophenotyping
- •Cytochemical study
- •Cytogenetics and molecular genetics (FISH)
- •Prognosis in acute leukemia
- •Treatment of leukemia
- •Male patient., 85 years old
- •Physical examination at admission
- •Chronic myelogenous leukemia
- •Mechanism of formation of Philadelphia chromosome
- •Epidemiology оf CML
- •Phases of CML
- •Diagnostics of CML
- •Blood smear in CML
- •Bone marrow in CML
- •Blastic crisis
- •Cytogenetics
- •Treatment targets
- •Principles of treatment
- •Chronic lymphocytic leukemia
- •Epidemiology and etiology of CLL
- •Clinical presentation
- •Classification of CLL (Binet) (1989)
- •Diagnostic criteria
- •Chronic lymphocytic leukemia
- •Mature lymphocytes with normal structure. Gumprecht shadows
- •Bone marrow in CLL
- •Principles of treatment
- •Lymphomas
- •Hodgkin’s lymphoma
- •Clinical presentation
- •Stages of Hodgkin Lymphoma
- •Morphological classification
- •Diagnosis
- •Reed-Sternberg cells
- •Treatment
- •Non-Hodgkin’s lymphoma
- •Hodgkin’s vs
Reed-Sternberg cells
Treatment
•Radiation therapy
•Induction chemotherapy
•Salvage chemopherapy
•Stem cell transplantation
Non-Hodgkin’s lymphoma
Hodgkin’s vs
Non-Hodgkin’s lymphoma
Category |
Survival of |
Curability |
To treat or |
|
|
|
untreated |
|
not to treat |
|
|
patients |
|
|
|
|
|
|
|
Non- |
Indolent |
Years |
Generally |
Generally |
Hodgkin |
|
|
not curable |
defer Rx if |
lymphoma |
|
|
|
asymptomatic |
|
|
|
|
|
|
Aggressive |
Months |
Curable in |
Treat |
|
|
|
some |
|
|
|
|
|
|
|
Very |
Weeks |
Curable in |
Treat |
|
aggressive |
|
some |
|
|
|
|
|
|
Hodgkin |
All types |
Variable – |
Curable in |
Treat |
lymphoma |
|
months to |
most |
|
|
|
years |
|
|
|
|
|
|
|
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