Phases of CML

Diagnostics of CML

•Peripheral blood smear (leukocytosis with moderate basophilia and eosinophilia, normochromic normocytic anemia, platelet changes, presence of immature cells)

•Bone marrow biopsy:

Ph-chromosome (cytogenetics)

BCR/ABL (FISH)

Hypercellular bone marrow

Blood smear in CML

Bone marrow in CML

Blastic crisis

Cytogenetics

Treatment targets

Hematological remission (normalization of peripheral blood smear and disappearance of symptoms)

Cytogenetic remission (0% Ph1-positive cells)

Molecular remission (negative PCR for BCR- ABL gene)