CST 2015 / NF_kappaB
.pdf
CELL SIGNALING TECHNOLOGY |
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NF-κB Signaling |
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IL-1 |
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TNF |
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Growth Factors: |
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BMP, EGF, HGH, |
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LPS, CpG, |
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Insulin, NGF, TGF-α |
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LT, CD40L, |
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Ag-MHC |
ssRNA, dsRNA |
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IL-1R |
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TNFR |
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BAFF/BLys |
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Ag |
TLRs |
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GF-Rs |
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TCR |
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MyD88 |
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TRADD |
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LTβR, |
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BCR |
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ub |
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CD40, |
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IRAK1/4 |
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ubc13 |
Ras |
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BR3 |
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TRAF2/5 |
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TRAF2 |
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For detailed signaling, |
Pellino |
TRAF2/6 |
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RIP |
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TRAF3 |
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see TLR Pathway. |
A20 |
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For detailed signaling, |
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ub |
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cIAP1/2 |
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CYLD |
PI3K |
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see BCR Pathway. |
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Ubc13TRAF6 |
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ITCH TAX1BP1 |
LUBAC |
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For detailed signaling, |
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RNF11 |
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PDK1 |
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see TCR Pathway. |
UEV1A |
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TAB1/2 |
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TAB2/3 |
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Stress: ROIs, |
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TAK1 |
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Akt |
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TAK1 |
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IKKγ/ |
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Cot |
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NIK |
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UV, metals, |
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ischemia, shear |
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ubTRAF6 |
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ELKS IKKβ |
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NEMO |
Tax |
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IKKα |
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ub |
β-TrCP |
ub |
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IKKγ/ |
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β-TrCP |
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ub |
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ub NEMO |
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IKKα IKKα |
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JNK |
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ub |
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ub |
p65/ |
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CK2 |
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Proteasomal |
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RelA/cRel IκBα/β/ε |
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IκBα |
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Degradation |
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RelA |
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NF-κB2 RelB |
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p38 |
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NF-κB1 |
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NF-κB2 |
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ub |
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IKKα/β/ε |
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p52 |
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Genotoxic |
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p100 |
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UV |
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p50 |
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NAP1 NAK |
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PKCζ |
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GSK-3β |
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Stress |
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Nuclear-cytoplasmic |
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RSK1 |
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MSK1 |
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Proteasomal |
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shuttling of non- |
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phosphorylated forms |
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p65/ |
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Processing |
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ub K63-ubiquitin |
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ub |
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CYLD |
PKA C |
RelA |
CK2 |
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IKKγ/ |
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ub K48-ubiquitin |
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NF-κB |
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NEMO |
IKKα |
IKKα |
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Bcl-3 |
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p50/52 |
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NF-κB2 RelB |
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IκBζ |
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p52 |
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Cytoplasm
Nucleus
RelA/cRel IκBα/ε
NF-κB1 p50
NF-κB |
p65/ |
ac |
PCAF |
SUMOIKKγ/ |
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IKKα IKKα |
CBP/ |
NEMO |
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p50/52 |
RelA |
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p300 |
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NF-κB |
NF-κB |
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SUMO |
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NF-κB2 RelB |
p50/52 |
p50/52 |
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p52 |
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HDAC |
PIASγ ATM |
PARP1 |
H3 |
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Survival, Proliferation, Inflammation, Immune Regulation |
Lymphogenesis, B Cell Maturation |
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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