CST 2015 / TGF_beta
.pdf
CELL SIGNALING TECHNOLOGY |
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www.cellsignal.com |
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TGF-β Signaling |
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TGF-β Ligands: |
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BMP Ligands: |
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TGF-βs, Activins, Nodals |
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BMP-2, -4, -7, MIS |
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Type II |
Type I |
Type I |
Type II |
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Receptor |
Receptor |
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Receptor |
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Receptor |
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Shc |
GRB2 |
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Smurf1/2 TMEPAI |
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RhoA |
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Rac/ |
SARA |
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Cdc42 |
Smad2/3 |
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TAK1/MLK3/ |
mDia ROCK |
PAK |
Par6 |
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MEKK1 |
SOS |
Ras |
Smad1/5/8 |
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Smad7 |
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Smad7 |
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Erk1/2 Smad6 Smurf1 |
LIMK |
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PKC |
PI3K |
PP2A |
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Smad2/3 |
Smad1/5/8 |
MKK3/6 |
MLC |
LIMK |
c-Abl |
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Smad4 |
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Akt |
MKK3/6 |
MKK4 |
Smurf2 |
Smurf1 |
p38 |
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Cofilin |
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Cofilin |
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mTOR |
p38 |
JNK |
Smad2/3 Smad4 |
Smad1/5/8 Smad4 |
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Smad2/3 |
Smad1/5/8 |
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Actin Polymerization |
4E- p70 S6K |
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Stress Fibers |
BP1/2 |
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Actin Polymerization |
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Adhesion |
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Stress Fibers |
Cytoplasm
Nucleus
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Smad4 CBP |
Smad1/5/8 Smad4 CBP |
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Smad2/3Smad2/3 TF |
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Smad1/5/8 TF |
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Transcription Factors: |
Corepressors: |
Coactivators: |
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AP-1 |
homeodomain |
c-Ski/SnoN |
CBP/p300 |
bZIP |
Sp1 |
Evi1 |
SMIF |
RUNX |
nuclear receptors |
TGIF |
MSG1 |
Fox |
IRF-7 |
SIP1 |
ARC105 |
bHLH |
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Tob (BMP only) |
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HDAC4/5 |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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