CST 2015 / Toll_Like
.pdf
CELL SIGNALING TECHNOLOGY |
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Toll-like Receptor Signaling
LPS
dsRNA or 5'-triphosphate
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MD-2 |
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CD14 |
TLR4 TLR4 |
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TRAM |
TRIF |
TIRAP |
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Uropathogenic |
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Bacteria, |
Flagellin |
Profilin |
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R11TL TLR11 |
TLR5 R5LT |
MyD88 |
MyD88 |
MyD88 |
Triacyl
Lipopeptide
TLR2R1LT
MyD88TIRAP
Diacyl
Lipopeptide
MyD88 |
R2LT TR6L |
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TIRAP |
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RNA |
TRIAD3A |
ATP 
RIG-I
MAVS
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Anti-viral |
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n d |
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Compounds, |
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ssRNA |
ST2L |
SOCS1 |
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IRAK-4 |
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TOLLIP |
IRAK-M |
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TRAF3 |
RIP1 |
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IRAK-1 |
IRAK-2 |
FADD |
Casp-8 |
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A20 |
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IKKε |
Ubc13TRAF6 |
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Apoptosis |
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ECSIT |
MEKK-1 |
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TBK1 |
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UEV1A |
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CpG dsRNA
TRL9 9TRL |
R7LT |
TRL8 |
TRL3 LR3T |
MyD88 |
MyD88 |
MyD88 |
TRIF |
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IKKγ/
NEMO
IKKβ IKKα 
TAK1 
MKK 3/6
TAB1/2
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MKK 4/7 |
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IκBαub |
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p38 MAPK |
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p65/RelA |
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IRF-7 |
IRF-3 |
Proteasomal |
NF-κB |
JNK |
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IRF-7 |
IRF-3 |
Degradation |
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Cytoplasm
Nucleus
Transcription
Factors
Inflammation, Immune Regulation, Survival, Proliferation
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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