CST 2015 / Ubiquitin_Proteasome
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CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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Ubiquitin/Proteasome
ATP |
AMP |
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E2 |
E1 |
Protein |
E2 |
Ub |
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Substrate |
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Ub |
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E1 |
Ub |
E2 |
Ub |
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E3 |
E3 |
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DUB |
Protein |
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Ub |
Ub |
Substrate |
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Ub |
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Multiple |
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Ub |
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Cycles |
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Protein |
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ADP |
ATP |
Substrate |
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Ub |
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Protein |
Peptides |
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Substrate |
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19S |
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E3 Ubiquitin Ligases |
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20S |
26S |
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c-Cbl N-Terminal |
RING |
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UBA |
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Proteasome |
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c-Cbl (906 aa)
19S
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EF EF |
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WW Domains |
HECT |
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NEDD4 (1319 aa) |
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F-box |
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WD Domains |
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β-TrCP (605 aa) |
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F-box |
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LRR Repeats |
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Skp2 (424 aa) |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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