CST 2015 / T_Cell_Receptor
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CELL SIGNALING TECHNOLOGY |
www.cellsignal.com |
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T Cell Receptor Signaling
Ca2+
α β
TCR/CD3
Complex
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LAT |
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ζ |
ζ |
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- |
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Clhanne |
LAF |
Clustering |
GRB2 |
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Zap-70 |
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CCAR |
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Actinin Talin |
SOS |
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ADAP |
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PLCγ1 |
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F |
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i |
SLP76 |
HPK1 |
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A |
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c |
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Ca2+ |
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NCK |
Vav |
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n |
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CaM |
Calpain |
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Dlgh1 |
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WASP |
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δ ε |
ε |
γ |
CD4 |
CD45 |
CD28 |
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Lck |
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PI3K |
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DAG |
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PIP3 |
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PDK1 |
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Calcineurin CaMKIV Ca2+ IP3 |
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PIP2 |
Rac/cdc42 |
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PKC |
θ |
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Akt |
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DAG |
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TAK1 |
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c-Cbl |
MALT1Bcl10 Carma1 |
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CREB |
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MEKK1 |
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IP3R |
RasGRP |
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GADD45α |
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TAK1 |
IKKγ |
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mTORC1 |
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Intracellular |
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GβL |
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Raptor |
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IKKβ |
IKKα |
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Ca2+ Store |
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MKK4/7 |
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MKK7 |
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mTOR |
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Ras |
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DEPTOR |
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Rel |
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NFAT |
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IκB |
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JNK |
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JNK2 |
NF-κB |
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Raf |
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p38 MAPK |
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Cell Proliferation |
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NFAT |
MEK1/2 |
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IκB |
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Survival |
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Proteasomal |
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Erk1/2 |
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Degradation |
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Cytoplasm
Nucleus |
NFAT |
Fos |
Jun |
NF-κB Rel |
Nuclear |
IL-2 |
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Membrane |
Gene |
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Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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