CST 2015 / Warburg_Effect
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CELL SIGNALING TECHNOLOGY |
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Warburg Effect |
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Glycolysis |
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Growth Factors |
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Glucose |
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Glucose |
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Transporters |
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Ras |
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Hexokinase |
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PI3K |
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NADPH |
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NADP |
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c-Myc |
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Ras |
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Pentose |
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6-P- |
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Glucose-6-P |
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Akt |
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Phosphate |
6-P- |
Gluconolactone |
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Ras |
Amino Acids |
MEK1/2 |
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Shunt |
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NADP Gluconate |
p53 |
TIGAR |
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Fructose-6-P |
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NADPH |
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LKB1 |
SREBP |
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Ribulose-5P |
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PFK |
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AMPK |
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Erk1/2 |
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Fructose |
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mTOR |
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Nucleotide |
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PHGDH |
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Bisphosphate c-Myc |
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HIF-1α |
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Synthesis |
Serine |
3-Phosphoglycerate |
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Protein Synthesis Cell Proliferation |
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NADPH |
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c-Myc |
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Glycine |
NADP |
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PEP |
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ULK1 |
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HIF-1α |
PKM2 |
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Fatty Acid Oxidation |
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Malic Enzyme |
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c-Myc |
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Pyruvate |
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Autophagy |
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Fatty Acids |
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LDHA |
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Pyruvate |
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PDHK |
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Lactate |
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Malate |
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Pyruvate |
Dehydrogenase |
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Acetyl-CoA |
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Oxaloacetate |
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β-Oxidation |
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Akt |
Bax |
ANT |
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Hexokinase |
VDAC |
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ANT |
VDAC |
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OMM Stability
Inhibition Cytochrome C Release
Inhibition of Apoptosis
Malate |
Krebs |
Citrate |
Citrate |
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Cycle |
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IDH2 |
UCP2 |
ACL |
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Acetyl-CoA |
AMPK |
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α-Ketoglutarate |
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IDH1 |
ACC |
Fatty Acid/ |
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NADP |
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Glutaminase |
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Lipid Synthesis |
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p53 |
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NADPH |
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Glutamine Transporters |
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Glutamine
Glutaminolysis
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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