CST 2015 / Wnt_beta_Catenin
.pdf
CELL SIGNALING TECHNOLOGY |
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www.cellsignal.com |
Wnt/β-Catenin Signaling |
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OFF-State |
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ON-State |
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WIF |
RTK |
DKKs SFRP |
Wnt |
SFRP |
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TGF-β/BMP |
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Cadherin |
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PRL
p120 β-catenin
α-catenin
Frizzled |
RPL |
Frizzled |
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Dvl |
CK1 |
Axin Dvl |
GSK-3 |
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Naked |
Tankyrase
Src Fer
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GBP |
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PP2A |
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APC Axin GSK |
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-3 |
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β-TrCP |
WTX |
β-catenin |
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CK1 |
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ub β-catenin
Proteasomal
Degradation
Cytoplasm
Nucleus
Groucho HDAC
OFF 
LEF/TCF
HDAC
Groucho β-catenin
Hesx1
Prop1
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
Phosphatase |
pro-apoptotic |
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Acetylase |
Transcription Factor |
pro-survival |
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Deacetylase |
Caspase |
GAP/GEF |
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Ribosomal subunit |
Receptor |
GTPase |
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Direct Stimulatory |
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Modification |
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CYLD |
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ubDvl |
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PAR-1 |
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β-catenin |
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ubTAK1 TAB2 |
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TAB1 |
Rac1 |
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NLK |
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RA |
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RAR |
ICAT |
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Chibby |
BCL9 Pygo |
NLK |
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CBP β-cateninCdk8 |
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Target Genes: |
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Myc, Cyclin D1, |
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LEF/TCF |
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TCF-1, PPAR-δ, |
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MMP-7, Axin-2, |
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CD44, etc. |
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β-catenin |
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Pit1 |
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Prop1 |
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Migration 
Adhesion
Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Modification |
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Tentative Stimulatory |
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Modification |
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