CST 2015 / Translation_eIF_2
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Translational Control: Regulation of eIF2
Salubrinal
Growth Factors,
Hormones, etc.
GSK-3β
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Unfolded Protein |
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UV, Amino Acid |
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Response, Hypoxia |
BiP |
Starvation |
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Viral Infection |
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Heme Deficiency, |
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dsRNA |
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Oxidative Stress |
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PERK |
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GCN2 |
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PERK |
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GCN2 |
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PKR PKR |
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HRI |
HRI |
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PP1 |
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α |
β |
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GADD34 |
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eIF2-GDP γ |
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eIF2B |
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αβ
eIF2-GDP γ |
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eIF5 |
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eIF2B |
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GTP |
NCK |
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eIF2B |
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GDP |
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α |
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β |
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β |
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eIF2-GDP γ |
eIF2-GDP γ |
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40S |
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Met-tRNA |
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Global Translation Off ATF-4 mRNA |
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eIF2-GTP |
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Translation |
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Met-tRNA |
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Ternary |
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eIF3 |
Complex |
eIF1 |
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Apoptosis, Changes in |
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eIF1A |
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eIF5 |
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Metabolism & Redox Status |
43S
Global Translation On
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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