CST 2015 / Regulation_Actin
.pdf
CELL SIGNALING TECHNOLOGY |
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Regulation of Actin Dynamics
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Integrin |
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RTK |
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GPCR |
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Sema1a |
Receptor |
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PlexinA |
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PI3K |
PLCγ |
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PIP2 |
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PI3K |
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Gi |
Gq Gs G13 |
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Src |
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Grb2 |
Nck |
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F-actin |
Mical |
Paxillin FAK |
PIP3 |
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Ca2+ |
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PKCα |
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CaM |
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PLCβ |
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Bundles/ |
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Meshworks |
NADPH |
GRB2 |
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PAK1 WASP |
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Fascin |
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PIP3 |
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PI3Kα |
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Severed |
NADP |
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GEF |
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Filopodia |
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Ena |
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Filaments |
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p130 |
GIT1/2 |
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Ras |
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PKA |
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VASP |
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PIP3 |
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PI3K |
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PI3K |
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PIX |
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MEKK |
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Cofilin |
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TIAM1 |
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RhoGEF |
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Vav |
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PIX |
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Degradation |
Crk |
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MEKK |
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Rac |
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cdc42 |
PAK1 |
MEK |
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Rho |
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PAK1 |
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Cortactin |
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mDIA |
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WAVE |
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ROCK |
Filamin |
WASP |
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ROCK |
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PI5K |
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MLCK |
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MBS |
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2+ |
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2 |
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PKD1 |
LIMK |
MLCK |
mDIA |
Arp2/3 |
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Filamin |
Profilin |
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14-3-3ζ |
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Calcineurin |
SSH |
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MLC |
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CIN |
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Cofilin |
ADF |
Filopodia |
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Lamellipodia |
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Barbed-end |
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Gelsolin |
Hsp90 |
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CapZ |
Cappers |
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Pointed-end |
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Actin |
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Tmod Cappers |
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Lamellipodia |
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Stress Fibers |
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Polymerization |
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Tropomyosins
Pathway Diagram Keys
Kinase |
Enzyme |
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G-protein |
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Direct Inhibitory |
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Tentative Inhibitory |
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Translocation |
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Phosphatase |
pro-apoptotic |
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Acetylase |
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Modification |
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Modification |
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Transcriptional |
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Multistep Stimulatory |
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Separation of Subunits |
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Stimulatory Modification |
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Transcription Factor |
pro-survival |
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Deacetylase |
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Modification |
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or Cleavage Products |
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Transcriptional |
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Caspase |
GAP/GEF |
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Multistep Inhibitory |
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Joining of Subunits |
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Inhibitory Modification |
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Ribosomal subunit |
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Modification |
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Receptor |
GTPase |
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Direct Stimulatory |
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Tentative Stimulatory |
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Modification |
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Modification |
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