APLA,Y
MEDICAL
USMLE™* Step 1
Pathology
Lecture Notes
BK4031 J |
·usMLE™ is a joint program of the Federation of State Medical Boards of the United States and the National Board of Medical Examiners. |
©2013 Kaplan, Inc.
All rights reserved. No part ofthis book may be reproduced in any form, by photostat, microfilm, xerography or any other means, or incorporated into any information retrieval system, electronic or mechanical, without the written permission of Kaplan, Inc.
Not for resale.
Authors
Henry Sanchez, M.D.
Professor of Clinical Pathology
University ofCalifornia, San Francisco
San Francisco, CA
John Barone, M.D.
Anatomic and Clinical Pathologist
BeverlyHills, CA
Contributors
Michael S. Manley, M.D.
Department ofNeurosciences
University of California, San Diego
Senior Director, Step 1 Curriculum
Kaplan Medical
Nancy Standler, M.D., Ph.D.
DepartmentofPathology
Valley View Medical Center
Intermountain Health Care
Contents
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
. vii |
Chapter 1: Fundamentals of Pathology . . . . . . . . . . . . . . . . . .. .. . . . . . . . . |
. 1 |
Chapter 2: Cellular Injury and Adaptation . . . . . . . . . . . . . . . . .. . . . . . . . . |
. 5 |
Chapter 3: Inflammation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . |
15 |
Chapter 4: Tissue Repair. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
25 |
Chapter 5: Circulatory Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
29 |
Chapter 6: Genetic Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
43 |
Chapter 7: lmmunopathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
59 |
Chapter 8: Amyloidosis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
69 |
Chapter 9: Principles of Neoplasia. . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . |
73 |
Chapter 10: Environmentand Lifestyle-Related Pathology. . . . . . . . . . . . . |
83 |
Chapter 11: Skin Pathology. . . . . . . . . . . . . . .. . . . . .. . . . . . . . . . . . . . . . . . |
89 |
Chapter 12: Red Blood Cell Pathology: Anemias . . .. . . . . . . . . . . . . . . . . . |
97 |
Chapter 13: Vascular Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
109 |
Chapter 14: Cardiac Pathology. . . . . . .. . . . . . . . . . . . . . . . . . . . . . . .. . . . |
119 |
Chapter 15: Respiratory Pathology............................... . |
131 |
Chapter 16: Renal Pathology ........... ......................... |
147 |
Chapter 17: Gastrointestinal Tract Pathology ....................... |
163 |
Chapter 18: Pancreatic Pathology . ............................... |
177 |
Chapter 19: Gallbladder and Biliary Tract Pathology................. |
183 |
M EDICAL V
Chapter 20: Liver Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
187 |
Chapter 21: Central Nervous System Pathology . . . . . . . . . . . . . . . . . . . . . |
197 |
Chapter 22: Hematopoetic Pathology-White Blood Cell |
|
Disorders & Lymphoid and Myeloid Neoplasms . . . . . . . . . . |
219 |
Chapter 23: Female Genital Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
233 |
Chapter 24: Breast Pathology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
241 |
Chapter 25: Male Pathology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
247 |
Chapter 26: Endocrine Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
253 |
Chapter 27: Bone Pathology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
261 |
Chapter 28: Joint Pathology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
271 |
Chapter 29: Skeletal Muscle and Peripheral Nerve Pathology . . . . . . . . . |
277 |
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
283 |
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Preface
These 7 volumes ofLecture Notes represent the most-likely-to-be-tested material on the current USMLE Step 1 exam. Please note that these are Lecture Notes, not re view books. The Notes were designed to be accompanied by facultylectures-live, on video, or on the web. Reading them without accessing the accompanying lectures is not an effective way to review for the USMLE.
To maximize the effectiveness of these Notes, annotate them as you listen to lectures. To facilitate this process, we've created wide, blank margins. While these margins are occasionally punctuated by faculty high-yield "margin notes;' they are, for the most part, left blank for your notations.
Many students find that previewing the Notes prior to the lecture is a very effective way to prepare for class. This allows you to anticipate the areas where you'll need to pay particular attention. It also affords you the opportunity to map out how the in formation is going to be presented and what sort of study aids (charts, diagrams, etc.) you might want to add. This strategy works regardless of whether you're attending a live lecture or watching one on video or the web.
Finally, we want to hear what you think. What do you like about the Notes? What could be improved? Please share your feedback by e-mailing usatmedfeedback@kaplan.com.
Thank you forjoining Kaplan Medical, and best of luck on your Step 1 exam!
Kaplan Medical
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