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Authors
Craig Davis, Ph.D.
Distinguished Professor Emeritus
University ofSouth Carolina School ofMedicine
Department ofPharmacology, Physiology, and Neuroscience
Columbia, SC
Steven R. Harris, Ph.D.
Associate DeanforAcademicAffairs
Professor ofPharmacology
Kentucky College ofOsteopathic Medicine
Pikeville, KY
Contributor
Laszlo Kerecsen, M.D.
Professor ofPharmacology
Midwestern UniversityAZCOM
Glendale, AZ
Contents
Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix
Section I: General Principles |
|
Chapter 1: Pharmacokinetics. . . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
. 3 |
Chapter 2: Pharmacodynamics . . . . . . . . . . . . . . . . . .... . . . . ... . . . . ... |
19 |
Chapter 3: Practice Questions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
29 |
Section II: Autonomic Pharmacology |
|
Chapter 1: The Autonomic Nervous System (ANS) . . . . . . . . . .. . . . . . . . . |
39 |
Chapter 2: Cholinergic Pharmacology . . . . . . . . . . . . . . . . . .. . . . . . ... . . |
45 |
Chapter 3: Adrenergic Pharmacology. . . . . ... . . . . . . . . . . . . . . . . . . . . . . |
55 |
Chapter 4: Autonomic Drugs: Glaucoma Treatment and |
|
ANS Practice Problems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
65 |
Chapter 5: Autonomic Drug List and Practice Questions . . . . . . . . . . . .. . |
.71 |
Section Ill: Cardiac and Renal Pharmacology |
|
Chapter 1: Fundamental Concepts . . . . . . . . . .. .. . . . . . . . . . . . . . . . . . . . |
83 |
Chapter 2: Antiarrhythmic Drugs . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . |
89 |
Chapter 3: Antihypertensive Drugs.. . .. . . . . . . . . . . . . . . . . . . . . . . . .. .. |
93 |
Chapter 4: Drugs for Heart Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
99 |
Chapter 5: Antianginal Drugs . .................................. |
103 |
Chapter 6: Diuretics . . . . . . . . . . . . . . . . .. . . .. . . . . . . . . . . . . . . ... . . . . . |
107 |
Chapter 7: Antihyperlipidemics . . . . . . . . . . ... . . . . . . . . . . . . . . . . . . . ... |
115 |
Chapter 8: Cardiac and Renal Drug List and Practice Questions . . . . . . . . |
119 |
MEDICAL V
USMLE Step I • Pharmacology
Section IV: CNS Pharmacology |
|
Chapter 1: Sedative-Hypnotic-Anxiolytic Drugs ............... ....... |
131 |
Chapter 2: Alcohols ........................................... |
135 |
Chapter 3: Anticonvulsants ....... . . ...................... .... .. |
137 |
Chapter 4: Drugs Used in Anesthesia . ............................. |
141 |
Chapter 5: Opioid Analgesics ................ .. . ................. |
147 |
Chapter 6: Drugs Used in Parkinson Disease and Psychosis ........... |
151 |
Chapter 7: Drugs Used for Depression, Bipolar Disorders, |
|
and Attention Deficit Hyperactivity Disorder (ADHD) ...... |
157 |
Chapter 8: Drugs of Abuse ......... ............................. |
161 |
Chapter 9: CNS Drug List and Practice Questions............... .... |
163 |
Section V. Antimicrobial Agents |
|
Chapter 1: Antibacterial Agents..... .................. .... . ....... |
175 |
Chapter 2: Antifungal Agents... .......... ............. .... ....... |
191 |
Chapter 3: Antiviral Agents ..................................... |
195 |
Chapter 4: Antiprotozoal Agents. ... .. ................ ... ........ |
203 |
Chapter 5: Antimicrobial Drug List and Practice Questions . . .. ....... |
205 |
Section VI. Drugs for Inflammatory and Related Disorders |
|
Chapter 1: Histamine and Antihistamines . .. ............. ... ....... |
217 |
Chapter 2: Drugs Used in Gastrointestinal Dysfunction ............... |
219 |
Chapter 3: Drugs Acting on Serotonergic Systems ............ .. .... |
223 |
Chapter 4: Eicosanoid Pharmacology......................... .... |
225 |
Chapter 5: Drugs Used for Treatment of Rheumatoid Arthritis ........ |
231 |
Chapter 6: Drugs Used for Treatment of Gout................... ... |
233 |
Vi MEDICAL
Contents
Chapter 7: Glucocorticoids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235
Chapter 8: Drugs Used for Treatment of Asthma . . . . . . . . . . . . . . . . . . . 237
Chapter 9: List of Drugs for Inflammatory. . . . . . . . . . . Disorders. . . . . . . . . and. . . . . . . . . . . . . . . . . . . 241
Practice Questions
Section VII: Drugs Used in Blood Disorders |
|
Chapter 1: Anticoagulants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
255 |
Chapter 2: Thrombolytics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
259 |
Chapter 3: Antiplatelet Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
261 |
Chapter 4: List of Drugs Used in Blood Disorders and |
|
Practice Questions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
263 |
Section VIII: Endocrine Pharmacology
Chapter 1: Drugs Used in Diabetes. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
Chapter 2: Steroid Hormones . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 275
Chapter 3: Antithyroid Agents. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 281
Chapter 4: Drugs Related to Hypothalamic and Pituitary Hormones . . . 283
Chapter 5: Drugs Used for Bone and Mineral Disorders . . . . . . . . . . . . . 285
Chapter 6: Endocrine Drug List and Practice Questions . . . . . . . . . . . . . . 287
Section IX: Anticancer Drugs |
|
Chapter 1: Anticancer Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
295 |
Chapter 2: Anticancer Drug Practice Questions. . . . . . . . . . . . . . . . . . . . . |
299 |
Section X: lmmunopharmacology
Chapter 1: lmmunopharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 303
Chapter 2: lmmunopharmacology Practice Questions . . . . . . . . . . . . . . . 305
MEDICAL |
Vii |
USMLE Step I • Pharmacology
Section XI: Toxicology
Chapter 1: Toxicology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309
Chapter 2: Toxicology Practice Questions . . . . . . . . . . . . . . . . . . . . . . . . . .315
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .317
viii MEDICAL
Preface
These 7 volumes ofLecture Notes represent the most-likely-to-be-tested material on the current USMLE Step 1 exam. Please note that these are Lecture Notes, not review books. The Notes were designed to be accompanied by faculty lectures live, on video, or on the web. Reading them without accessing the accompanying lectures is not an effective way to review for the USMLE.
To maximize the effectiveness of these Notes, annotate them as you listen to lec tures. To facilitate this process, we've created wide, blank margins. While these margins are occasionally punctuated by faculty high-yield "margin notes;' they are, for the most part, left blank foryour notations.
Many students find that previewing the Notes prior to the lecture is a very effec tive way to prepare for class. This allows you to anticipate the areas where you'll need to pay particular attention. It also affords you the opportunity to map out how the information is going to be presented and what sort of study aids (charts, diagrams, etc.) you might want to add. This strategy works regardless of whether you're attending a live lecture or watching one on video or the web.
Finally, we want to hear what you think. What do you like about the Notes? What could be improved? Please share your feedback by e-mailing us at medfeedback@ kaplan.com.
Thank you for joining Kaplan Medical, and best ofluck on your Step 1 exam!
Kaplan Medical
MEDICAL ix
SECTION
General
Principles
