2011-veres-Zaklyuchne--Biohimiya

Enzyme

carbamoyl phosphate synthetase II

aspartic transcarbamolyase (aspartate carbamoyl transferase)

dihhydroorotase

dihydroorotate dehydrogenase (the only mitochondrial enzyme)

orotate phosphoribosyltransfe rase

OMP decarboxylase

uridine-cytidine kinase 2

nucleoside diphosphate kinase

CTP synthase

Product

carbamoyl phosphate

carbamoyl aspartic acid

dihydrooro tate

orotate

OMP

UMP

UDP

UTP

CTP

Description

This is the regulated step in the pyrimidine biosynthesis.

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Dehydration

Dihydroorotate then enters the mitochondria where it is oxidised through removal of hydrogens. This is the only mitochondrial step in nucleotide rings biosynthesis.

PRPP is used.

Decarboxylation

Phosphorylation. ATP is used.

Phosphorylation. ATP is used.

Glutamine and ATP are used.