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34
Metals in Medicine, Volume 2
     Pharmacol. Res.
2019, 143, 178–185.
 
       
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 

IJN 2018, 13, 8411–8427.
 
        
IJN 2019, 14, 1817–1833.
         Hyperthermic
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
 
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         
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Metals in Medicine, Volume 2: Metallic Nanoparticles for Biomedical Applications.
Sonali Sundram, Rishabha Malviya, and GSN Koteswara Rao
© 2025 Apple Academic Press, Inc. Co-published with CRC Press (Taylor & Francis)
Zinc Oxide Nanoformulations for Cancer
Therapy
DHANALEKSHMI UNNIKRISHNAN MEENAKSHI
1
,
SELVASUDHA NANDAKUMAR
2
, POOVI GANESAN
3
, LEKSHMI SALIM
1
,
JOSEPH PUSHPA SWEETY
4
, and SHAH ALAM KHAN
1
1
College of Pharmacy, National University of Science and Technology,
Muscat, Oman
2
Department of Biotechnology, Pondicherry University, Puducherry, India
3
Mother Theresa Postgraduate and Research Institute of Health Sciences,
Puducherry, India
4
Anna University, Trichy Campus, India
CHAPTER 2
ABSTRACT
Nanoscale materials have great promise to treat cancer because they carry
           
several metal-oxide NPs are currently being created. A versatile material,
         
characteristics. Due to their biocompatibility, biodegradability, and distinc-
       

-
        
cells using ZnO nanoparticles as a targeted and long-lasting delivery vehicle.



https://t.me/med1917
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Metals in Medicine, Volume 2
stability , and dissolution rate in typical solutions are also highlighted. It also


      
   
therapy.
2.1 INTRODUCTION

  
-

   

        
          

1,2

      
and prostate cancer are next in line. Lung cancer continued to be the leading
     


      

screening, chemotherapy, surgical therapy, and immunotherapy.
3
     
cells, but alongside, the therapies like radiation therapy and chemotherapy
        

4


          
   




5,6
https://t.me/med1917
Zinc Oxide Nanoformulations for Cancer Therapy
41



 


suppressors, thus tumor suppressor genes become inactive and oncogenes get
activated. (b) Facilitated replicative immortality, the DNA telomers shrink
       
        





       
     
(d) Contact inhibition activates invasion and metastasis through NF2 gene
-

-
    

the genomic repair machinery, a rise in sensitivity to mutagenic agents, or a

undermining the monitoring systems that typically oversee genomic integrity

Reprogramming cellular metabolism, tumor cells can alter glucose metabo-



-


(i) Escaping immune destruction, by preventing immune system components

immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs),
tumor-associated dendritic cells, macrophages, neutrophils, and regulatory
          
https://t.me/med1917
42
Metals in Medicine, Volume 2





1,2



most likely explains noncellular drug resistance mechanisms and immu-
        

  
      

      

3



         




encapsulate medicines and other compounds, resulting in a higher therapeutic
dose. 5) NPs can selectively release a therapeutic product onto the target due


4,7,8

NPs are coupled to bioactive compounds such as peptides, DNA, proteins,
or chemotherapeutic agents. Additionally, inorganic NPs themselves exhibit

(Fe
2
O
3

3
O
4
) NPs, cerium oxide (CeO
2
) NPs, copper oxide (CuO) NPs,
       

-
          
      
(ZnO-NPs).
4
https://t.me/med1917
Zinc Oxide Nanoformulations for Cancer Therapy
43

-

10–15 mg, the human body already possesses roughly 2–3 g.
9
It is a crucial
-
     
         

10




      
11
   


12

 
research applications.
         

10,13
       -

10
 
       
creams, additionally as burn ointments.
        

to rubber composites.
8,5
      
luminescence.
5,13
        
-
nostics purposes due to its biocompatibility.
10

Zinc oxide nanoparticles have been approved by the FDA as a novel and
      
https://t.me/med1917