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Metals in Medicine, Volume 2
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Metals in Medicine, Volume 2: Metallic Nanoparticles for Biomedical Applications.
Sonali Sundram, Rishabha Malviya, and GSN Koteswara Rao
© 2025 Apple Academic Press, Inc. Co-published with CRC Press (Taylor & Francis)
Zinc Oxide Nanoformulations for Cancer
Therapy
DHANALEKSHMI UNNIKRISHNAN MEENAKSHI
1
,
SELVASUDHA NANDAKUMAR
2
, POOVI GANESAN
3
, LEKSHMI SALIM
1
,
JOSEPH PUSHPA SWEETY
4
, and SHAH ALAM KHAN
1
1
College of Pharmacy, National University of Science and Technology,
Muscat, Oman
2
Department of Biotechnology, Pondicherry University, Puducherry, India
3
Mother Theresa Postgraduate and Research Institute of Health Sciences,
Puducherry, India
4
Anna University, Trichy Campus, India
CHAPTER 2
ABSTRACT
Nanoscale materials have great promise to treat cancer because they carry
several metal-oxide NPs are currently being created. A versatile material,
characteristics. Due to their biocompatibility, biodegradability, and distinc-
-
cells using ZnO nanoparticles as a targeted and long-lasting delivery vehicle.
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Metals in Medicine, Volume 2
stability , and dissolution rate in typical solutions are also highlighted. It also
therapy.
2.1 INTRODUCTION
-
1,2
and prostate cancer are next in line. Lung cancer continued to be the leading
screening, chemotherapy, surgical therapy, and immunotherapy.
3
cells, but alongside, the therapies like radiation therapy and chemotherapy
4
5,6
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Zinc Oxide Nanoformulations for Cancer Therapy
41
suppressors, thus tumor suppressor genes become inactive and oncogenes get
activated. (b) Facilitated replicative immortality, the DNA telomers shrink
(d) Contact inhibition activates invasion and metastasis through NF2 gene
-
-
the genomic repair machinery, a rise in sensitivity to mutagenic agents, or a
undermining the monitoring systems that typically oversee genomic integrity
Reprogramming cellular metabolism, tumor cells can alter glucose metabo-
-
(i) Escaping immune destruction, by preventing immune system components
immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs),
tumor-associated dendritic cells, macrophages, neutrophils, and regulatory
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Metals in Medicine, Volume 2
1,2
most likely explains noncellular drug resistance mechanisms and immu-
3
encapsulate medicines and other compounds, resulting in a higher therapeutic
dose. 5) NPs can selectively release a therapeutic product onto the target due
4,7,8
NPs are coupled to bioactive compounds such as peptides, DNA, proteins,
or chemotherapeutic agents. Additionally, inorganic NPs themselves exhibit
(Fe
2
O
3
3
O
4
) NPs, cerium oxide (CeO
2
) NPs, copper oxide (CuO) NPs,
-
(ZnO-NPs).
4
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Zinc Oxide Nanoformulations for Cancer Therapy
43
-
10–15 mg, the human body already possesses roughly 2–3 g.
9
It is a crucial
-
10
11
12
research applications.
10,13
-
10
creams, additionally as burn ointments.
to rubber composites.
8,5
luminescence.
5,13
-
nostics purposes due to its biocompatibility.
10
Zinc oxide nanoparticles have been approved by the FDA as a novel and
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