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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5672_Библиотеки_им_академика_М_И_Перельмана
.pdf
14
Metals in Medicine, Volume 2
applied. Liu et al. developed gold-based nanoclusters (Au
25
(Capt)
18
)
concurrent photodynamic and photothermal treatments using 808 nm NIR
68
25
(Capt)
18
a high temperature (up to 60°
FIGURE 1.5
25
(Capt)
18
Au
25
(Capt)
18
nm, 2 W cm
2
mL1 Au
25
(Capt)
18
cm
2
1
O
2
by Au
25
(Capt)
18
2
1
O
2
by Au
25
(Capt)
18
Source
https://t.me/med1917
Gold-based Nanoparticles and Their Applications in Cancer Therapy
15
pH-responsive drug release properties (PEG-AuNRs-MPH
69
to
releasing the ALA and DOX into the cytoplasm. Upon exposure to NIR
the tumor (60°
cell death count, in addition to no systematic toxicity observed (Figure 1.6).
FIGURE 1.6
-PEG, and
2
2
), and 635 and 808
Source
https://t.me/med1917
16
Metals in Medicine, Volume 2
in internal organs (liver, lungs, kidney),
70,71
72
(Figure 1.7).
-
71
Despite these
advantages, this strategy is prone to several limitations including invasive
-
i.e., both normal and tumorous tissues around the electrodes experience
thermal injury.
73
FIGURE 1.7
Source
accumulate in the tumor, they are used as a target molecule to increase the
74
intracellular structures.
73
75
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Gold-based Nanoparticles and Their Applications in Cancer Therapy
17
cell lines.
76
77
Another distinctive
78
When combined
apoptosis).
79
1.3 SYNTHESIS OF AuNPs
three categories: Physical, Chemical, and Biological (including Green and
plant-based).
39
80
81
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18
Metals in Medicine, Volume 2
82
83
anticancer therapy applications including photothermal and photodynamic
their diameter or less).
1
84
controlled synthesis methods are
-
85
(Figure 1.8a).
variables.
86,87
6
H
5
Na
3
O
7
) to the chloroauric acid (HAuCl
4
)
-
86
88
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Gold-based Nanoparticles and Their Applications in Cancer Therapy
19
TABLE 1.2
.
Concentration (conc.) of
hydrogen tetrachloro aurate (M)
Conc. of
CTAB (M)
Conc. of
2,7-DHN (M)
Conc. of sodium
hydroxide (M)
Microwave
time (s)
Average size
(nm)
Shape distribution
3.17 e-04 6.34 e-03 3.17 e-03 1.15 e-02 90 25 ± 2
4.21 e-04 8.42 e-03 1.03 e-03 1.05 e-02 90 50–120
4.71 e-04 7.54 e-03 1.88 e-03 9.43 e-03 90 Aspect ratio
12 (530–720)
6.94 e-04 8.68 e-02 6.07 e-04 1.73 e-04 90 65 ± 10
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20
Metals in Medicine, Volume 2
nanoparticles.
89
aggregation. As a result, the incident particle occurs due to this aggrega-
tion,
89
FIGURE 1.8
90
Source
https://t.me/med1917
Gold-based Nanoparticles and Their Applications in Cancer Therapy
21
ions that
are converted into Au
0
atoms,
91
92
and poly(2-
aminothiophenol),
93
magnesium oxide
94
•
95
and it is
agent is sodium borohydride (NaBH
4
91
this method.
96
•
a reducing element, the sodium citrate is a capping agent that
•
4
4
agent
4
months, and NaBH
4
nm to 5 nm.
99
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22
Metals in Medicine, Volume 2
TABLE 1.3
Advantages and Disadvantages.
Method Advantages Disadvantages References
Frens
monodispersed AuNPs
nm
aggregation,
implementation in medical
and biological research.
97,98
Brust-
AuNPs,
nm,
stability and high thermal
properties,
Highly reproducible.
particles larger than 6 nm.
agent to produce AuNPs.
95
Martin
larger than 5 nm
agents are required to
99
-
in several studies to produce extracellular and intracellular AuNPs.
91
and physical characteristics.
Biomolecules: including nucleic acids, amino acids, carbohydrates, and
reducing the Au
ions to Au
0
https://t.me/med1917
Gold-based Nanoparticles and Their Applications in Cancer Therapy
23
-
based on processing Au
-
TABLE 1.4
Morphological Characteristics.
Plant-based extracts UV visual. SEM/DL/TEM FTIR spectroscopy EDS
560–800
nm
50–350 nm, hexagonal,
truncated triangular,
and triangular.
Alcoholic and
carbonyl groups
Dried Anacardium
occidentale leaves
260–530
nm
6–17 nm Proteins, polyphe-
nols, and aromatic
amines
-
Potamogeton
pectinatus
543 nm 8.5 nm O-H, COOH, C-C,
C-H, C-N and amide
C-O, N-H
and Si
Apiin compound
(henna leaves)
550–950
nm
21 nm, quasi-spherical
and triangular.
process involves
carbonyl groups.
–
Camellia sinensis
leaves
550 nm 30–40 nm – –
Chenopodium album
leaves
540 nm 10–30 nm
process involves
carboxyl groups.
Cinnamomum
camphora leaves
520–570
nm
10–40 nm, spherical
and triangular particles
Heterocyclic
compounds
Cymbopogon sp.
leaves
525 nm 200–500 nm, hexagonal
and triangular.
- -
Memecylon edule
leaves
530–555
nm
20–50 nm, hexagonal
and triangular.
Carbonyl stretching
Mentha piperita
(peppermint)
540 nm 5–150 nm, spherical
particles
N-H group
Si.
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