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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_1056_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Preface
- •Contents
- •About the Editors
- •Contributors
- •3 Host Factors: Age, Gender, Lifestyle
- •4 IBD and Other Etiologically Relevant Comorbid Conditions
- •5 Anatomical Presentation and Rectovaginal Fistula
- •6 Anal Fistula Development: Microbiological Factors
- •7 Recurrence and Cancer Risk
- •8 Conclusion
- •References
- •1 Epidemiology of Anal Fistula and Abscess
- •1 Introduction
- •2 Incidence and Prevalence
- •2.1 Europe
- •2.2 USA and Canada
- •2 Anorectal Anatomy Related to Anal Fistula and Abscess
- •1 Introduction
- •2 Mucosal Layer and Submucosal Space
- •3 Internal Anal Sphincter
- •4 Intersphincteric Space and Conjoint Longitudinal Muscle
- •5 External Anal Sphincter
- •6 Pelvic Floor
- •7 Extra-anal Spaces/Ischioanal Fossae
- •8 Anal Glands
- •10 Conclusion
- •11 Cross-References
- •References
- •3 Anorectal Physiology Related to Anal Fistula and Abscess
- •1 Principal Aspects of Anorectal Physiology
- •1.1 Secretory Function of the Anorectum and the Cryptoglandular Hypothesis
- •1.2 Histology and Cellular Physiology of the Anorectum and Fistula
- •1.3 Microbiology and Fistula
- •1.4 Host Factors Relevant to Abscess and Fistula
- •1.5 Anal Continence
- •1.5.1 The Rectum
- •1.5.2 The Musculature of the Pelvic Floor and Sphincter Complex
- •1.6 Defecation
- •1.7 Anorectal Physiology Testing in the Context of Fistula
- •1.7.2 Perioperative Anorectal Physiology Testing
- •2 Conclusion
- •References
- •4 Unconventional Insights in the Pathogenesis and Etiology of Fistulas in the Perianal Region
- •1 Introduction
- •1.1 Etiology
- •1.2 Risk Factors for Development of Perianal Fistula
- •1.3 Risk Factors due to the Type of Perianal Fistula
- •1.4 Treatment-Related Risk Factors for Failure
- •1.5 Preliminary Conclusions
- •2.1 Anatomy of the Anal Canal
- •2.2 Histology of the Anal Canal
- •2.3 Histopathologic Concepts of Perianal Fistulas
- •3.1 Old Stories, New Histopathological Concepts?
- •3.2 Old Stories, New Clinical Concepts?
- •3.2.1 Basic Concepts
- •3.3 Based on Previous Medical History
- •3.4 Aspect and Localization of the Fistula Opening
- •3.5 Phenotype 1
- •3.6 Phenotype 2
- •3.7 Phenotype 3
- •3.8 Phenotype 4
- •3.9 Phenotype 5
- •4 Discussion and Conclusions
- •5 Cross-References
- •References
- •5 From Abscess to Fistula
- •1 Anorectal Abscess
- •References
- •6 Classification of Anal Fistula and Abscess
- •1 Introduction
- •2 Purpose and Attributes of a Classification
- •3 Overview of Anal Fistula Classifications
- •4 Anal Fistula Classifications
- •4.1 Parks Classification
- •4.1.1 Strong Points
- •4.1.2 Weak Points
- •5.1 Strong Points
- •5.2 Weak Points
- •6 Garg Classification
- •6.6 Strong Points
- •6.7 Weak Points
- •7 Status of Extrasphincteric Fistulas
- •8 Evaluation of Existing Classifications on Long-Term Data
- •9 Conclusions
- •References
- •7 Clinical Assessment of Anal Cryptoglandular Abscess and Fistula
- •1 Introduction
- •2 Types of Clinical Evaluation
- •3 Diagnosis
- •4 Topographic Evaluation
- •4.1 The Cryptic Endoanal Primary Opening
- •4.2 The Secondary Opening or Openings
- •4.3 The Main Tract of the Fistula
- •4.4 Possible Purulent Collections
- •1.1 Physical Examination of the Anus and Rectum: General Principles
- •4.5 Possible Secondary Extensions
- •5 Conclusion
- •References
- •8 Clinical Assessment of Crohn Perianal Abscesses and Fistulas
- •1 Introduction
- •1.2 Inspection
- •1.3 Palpation
- •1.4 Endoscopy
- •2 Clinical Presentation
- •2.1 Skin Lesions
- •2.2 Fistulas
- •2.3 Abscesses
- •2.4 Diagnostic Workup
- •2.4.1 General Principles
- •2.5 US
- •2.6 Effectiveness and Sensitivity
- •2.6.1 Endoscopy
- •2.7 MRI
- •2.7.1 CT Scan
- •2.7.2 Fistulography
- •2.8 Diagnostic Follow-up
- •References
- •9 Anorectal Physiology Assessment in Patients with Anal Fistula: When Necessary
- •1 Introduction
- •2 Anorectal Physiology Assessment
- •2.1 Anamnesis
- •2.2 Physical Examination
- •2.3 Anorectal Manometry
- •2.3.1 Equipment
- •2.3.2 Manometry Systems
- •2.4 Neurophysiologic Tests
- •2.4.1 Electromyography
- •2.4.2 Nerve Conduction Studies
- •2.5 Endoanal Ultrasound
- •2.6 Role of Anorectal Physiology Patterns in the Decision-Making
- •3 Discussion
- •References
- •1 Introduction
- •2 Anal Anatomy
- •3 Classification of Fistulas
- •4 EAUS Imaging
- •4.1 Probes EAUS
- •4.2 Performing EAUS
- •4.3 EUS in Perianal Fistulas
- •4.4 Adding Hydrogen Peroxide (H2O2)
- •4.5 Cryptoglandular Fistulas
- •5 Comparison with Other Diagnostic Modalities
- •5.1 Comparison with Surgery
- •5.2 Comparison with MRI
- •5.3 Perineal Ultrasound
- •6 Conclusion and Recommendation
- •References
- •1 Introduction
- •2 Imaging
- •2.1 Conventional Contrast Material-Enhanced Fistulography
- •2.2 CT
- •2.3 Magnetic Resonance Imaging
- •2.3.1 Anatomy MRI
- •2.3.2 MRI Technique (Coils, Volume, and Sequences) and Findings
- •2.3.3 MRI Reconstruction Techniques and Fistulography MRI
- •2.3.4 Internal and Cutaneous Opening
- •2.3.5 Classifications of Perianal Fistulas and Abscesses
- •2.3.6 Deep Posterior Anal Fistulas and Abscess
- •2.3.7 MRI Report
- •2.3.9 MR Role in the Evaluation of the Crypto-Glandular Fistulas
- •3 Conclusion
- •4 Cross-References
- •References
- •1 Introduction
- •2 Clinical Presentation
- •3 Utility and Limitations of Endoanal Ultrasound
- •4 Conclusion
- •5 Cross-References
- •References
- •1 Introduction
- •2 Imaging
- •3 Diagnosis
- •4 MRI Technique
- •5 Disease Monitoring
- •6 Future Directions
- •7 Conclusion
- •8 Cross-References
- •References
- •14 Future Perspectives in the Diagnosis of Anal Fistula and Abscess
- •1 Introduction
- •2 Assessment of Abscess and Anal Fistula
- •3 Abscess
- •3.1 Computed Tomography (CT)
- •3.2 Magnetic Resonance Imaging (MRI)
- •3.3 Endoanal Ultrasound
- •3.4 Transperineal Ultrasonography (TP-US)
- •4 Anal Fistula
- •4.1 Imaging
- •4.1.1 Endoanal Ultrasound
- •4.1.2 Magnetic Resonance Imaging
- •5 Conclusion
- •6 Cross-References
- •References
- •15 How to Drain an Abscess
- •1 Introduction
- •2 Epidemiology and Etiology
- •3 Classification
- •4 Clinical Manifestations and Diagnosis
- •5 Management
- •7 Wound Dressing
- •8 Microbiology and Antibiotics
- •9 General Postoperative Management
- •10 Conclusion
- •11 Cross-References
- •References
- •16 The Seton in Anal Fistula Management
- •1 Introduction
- •2 2500 Years of Setons
- •3 To Put or Not to Put
- •4 To Cut or Not to Cut
- •5 What Kind of Seton to Use?
- •7 Seton 2.0: New Perspectives
- •8 Uncomfortable Questions (How to Do It)
- •9 What Patients Should Know
- •10 Conclusions: Seton in Guidelines
- •References
- •17 Fistulotomy
- •1 Introduction
- •2 Indications
- •3 Fistulotomy: Standard Technique
- •4 Other Fistulotomy Techniques
- •4.1 Addition of Loose Seton
- •4.2 Slow Dissection of the Sphincter: Cutting Seton
- •4.3 Addition of Marsupialization
- •5 Fistulotomy with Immediate Primary Sphincteroplasty (FIPS)
- •7 Postoperative Care
- •8 Complications and Recurrence Rate
- •9 Discussion
- •10 Conclusion
- •References
- •18 Fistulectomy
- •1 Introduction
- •2 Preoperative Evaluation
- •2.1 Patient Selection
- •2.2 Imaging
- •2.3 Physiologic Testing
- •2.4 Endoscopic Examination
- •3 Technique
- •3.1 Patient Preparation
- •3.2 Patient Positioning
- •3.2.1 Technical Steps
- •4 Postoperative Care
- •5 Results
- •5.1 Fistulectomy
- •6 Fistulectomy with Sphincter Reconstruction
- •7 Conclusions
- •References
- •19 Utility of Adding Sphincter Reconstruction to Fistulotomy/Fistulectomy
- •1 Introduction
- •2 General Classification
- •3 Preoperative Preparation
- •4 Surgical Technique Step by Step
- •5 Results
- •6 Conclusion
- •7 Cross-References
- •References
- •20 Utility of Marsupialization Following Anal Fistula Surgery
- •1 Introduction
- •2 Marsupialization
- •3 Clinical Evidence
- •4 Conclusion
- •References
- •21 Transanal Advancement Flap Repair
- •1 Introduction
- •2 Nomenclature
- •3 Effectiveness of the Technique
- •4 Effectiveness of Repeat Procedures
- •5 Impact on Fecal Continence
- •6 Severity of Incontinence
- •7 Perioperative Care
- •7.1 Bowel Preparation
- •7.2 Antibiotic Prophylaxis
- •7.3 Prolonged Antibiotic Therapy
- •7.4 Type of Anesthesia
- •7.5 Immobilization
- •7.6 Bowel Confinement
- •7.7 Stool Softeners
- •7.8 Position
- •8 Aspects of Surgical Technique
- •8.1 Preoperative Care
- •8.2 Step 1
- •8.3 Step 2
- •8.4 Step 3
- •8.5 Step 4
- •8.6 Step 5
- •8.7 Postoperative Care
- •8.8 Types of Flap
- •8.9 Shape of Flap
- •8.10 Thickness of Flap
- •8.11 Addition of Accessory Techniques
- •9 Necessity of Preoperative Imaging
- •10 Factors Contributing to Successful Healing
- •10.1 Fistula-Related Factors
- •10.2 Patient-Related Factors
- •10.3 Influence of Covering Ostomy
- •10.4 Impact of the Use of Draining Setons
- •11 Conclusion
- •References
- •22 Dermal Flap Anoplasty for Trans-sphincteric Anal Fistula
- •1 Rationale
- •2 Technique
- •3 Other Dermal Flaps
- •4 Discussion
- •5 Cross-References
- •References
- •23 (LIFT) Ligation of Intersphincteric Fistula Tract
- •References
- •24 Anal Fistula: Glue and Paste Injection
- •1 Introduction
- •2 Fibrin Glue
- •3 Collagen Paste
- •4 Conclusion
- •5 Cross-References
- •References
- •25 VAAFT
- •1 Introduction
- •1.1 VAAFT Story
- •2 Surgical Equipment and Accessories
- •3 VAAFT Indications
- •3.1 Preoperative Assessment
- •4 VAAFT Procedure
- •4.1 Diagnostic Phase (Fistuloscopy)
- •4.2 Operative Phase
- •5 Closure of the Internal Opening
- •5.1 Use of a Linear or Semicircular Stapler
- •5.2 Advancement Flap
- •5.3 Use of a Bioabsorbable Mesh (Xenograft)
- •5.4 Autologous Dermis Graft
- •5.4.1 VAAFT Associated to the LIFT Procedure
- •5.5 Postoperative Management
- •6 Discussion
- •7 Conclusions
- •References
- •26 The Laser Treatment of Anal Fistulas
- •1 Introduction
- •1.1 Literature Review
- •1.3 Diagnosis and Treatment of Complex Anal Fistulas
- •2 Materials and Methods
- •3 Conclusion
- •References
- •27 Treatment by Over-the-Scope-Clip
- •1 Introduction
- •2 Technical Background
- •3 Surgical Application
- •4 Principle of Action
- •5 Clinical Data
- •References
- •28 Stem Cells in Cryptoglandular Anal Fistulas
- •1 Introduction
- •2 History of a Novel Approach
- •2.1 Mesenchymal Stem Cells
- •2.2 Adipose Tissue: The Ideal MSCs Source
- •2.3 Adipose Tissue Graft
- •2.3.1 Lipogems
- •3 Results
- •3.1 Literature Review
- •3.2 Personal Experience
- •4 Discussion and Conclusion
- •References
- •1 Introduction
- •2 Perianal and Rectovaginal Fistulas
- •2.1 Epidemiology and Diagnosis
- •2.2 Classification
- •2.3 Treatment Modalities
- •3 Flap Reconstruction
- •3.1 Overview and Considerations for Flap Reconstruction
- •4 Gracilis Interposition Flap
- •4.1 Background and Indications
- •4.2 Operative Technique
- •4.3 Results/Complications
- •5 Martius Interposition Flap
- •5.1 History and Indications
- •5.2 Surgical Technique
- •5.3 Results/Complications
- •6 Gluteal Muscle Interposition Flap
- •6.1 History and Indications
- •6.2 Surgical Technique
- •6.3 Results/Complications
- •7 Conclusion
- •References
- •30 Quality of Life Following Anal Fistula Treatment
- •1 Introduction
- •2 Quality of Life with an Anal Fistula
- •2.1 Cryptoglandular Fistulas
- •2.3 Conclusion
- •3 Quality of Life with a Seton and a Fistula

346 D. D. E. Zimmerman
pathophysiologic basis was shown. Moreover, this factor is modifiable (it is often
possible for patients to discontinue smoking perioperatively). In our opinion, it is
worthwhile to counsel patients about their smoking behavior and give them the
advice to discontinue smoking cigarettes. When fistula repair will not be performed
on short notice, weight loss may be considered as well.
10.3 Influence of Covering Ostomy
Sonoda and coworkers compared patients undergoing flap repair with and without a
covering colostomy within a heterogenous retrospect ive group of patients (Sonoda
et al. 2002). Sixty-four patients underwent advancement flap repair with a covering
stoma, resulting in a healing rate of 72%. Twenty-five patients had a covering
colostomy. In these patients, advancement flap repair was successful in only 60%.
Even though this difference was not statistically significant, and it seems likely the
more challenging cases may have been offered a stoma, this study did not suggest an
advantage of a covering stoma. Similar findings were reported by Mizarahi and
coworkers (Mizrahi 2002), even though they had only three patients who had a
covering ostomy (Mizrahi et al. 2002). In their excellent review of literature, Soltani
and Kaiser (Soltani and Kaiser 2010a) found that in the studies they included, 4,4%
of all patients required a stoma. They suggested that although the impact of a stoma
on outcome is very likely, they cannot make any meaningful conclusions based on
the paucity of specific data. Despite the assumption of these authors, there is no
supportive evidence in literature to support the assumption that covering ostomies
ameliorate outcome of advancement flap repair.
10.4 Impact of the Use of Draining Setons
Interestingly, as stated before, none of the author s who investigated the role of
preoperative seton drainage showed a statistically significant higher healing rate in
patients in whom a seton was placed, before undergoing advancement flap repair.
Even though these investigations prompted us to refrain from prior seton placement
more often, still a considerable percentage of patients will undergo seton drainage
before advancement flap repair, either in the referring hospital or because of
excessive inflammation on preoperative MRI. Paradoxically, this suggests that
the most difficult cases would be prone to undergo seton drainage. Remarkably,
not only i s the healing rate in these patients not higher than patients w ithout prior
seton drainage, some authors found it to be lower (Sonoda et al. 2002). Seton
placement before advancement flap repair is a well-accepted treatment regime.
Many surgeons would advocate seton placement is an important preparatory step
before flap repair. It could be reasoned that because of the judicious use of setons,
good results can be obtained in the more complex group of patients. It is very hard
to draw meaningful conclusions from the available literature, apart from the
conclusion that the benefit of prior seton drainage cannot be proven and is therefore

21 Transanal Advancement Flap Repair 347
questionable. In our opinion, seton placement can still be part of an adequate
treatment plan. A thorough curettage followed by placement of a comfortable seton
may decrease the amount of active inflammation, thereby minimizing the size of
external wounds at a later time. However, a good reason for seton placement has to
be present. Placement of setons as part of a standardized treatment regimen are not
supported by literature in our opinion.
11 Conclusion
In conclusion, advancement flap repair is a well-investigated technique, yielding
good results in the treatment of perianal cryptoglandular fistulas. It may be expected
that 80% of fistulas will heal after advancement flap repair. The impact on fecal
continence is predictable and will affect about 13% of patients. We advocate the use
of thicker flaps where possible. There are few modifiable factors that seem to effect
healing. Smoking cessation and weight loss may be considered. There is no evidence
to support the use of diverting stomas. Placement of setons as part of a standardized
treatment regimen are not supported by literature. It is unadvisable to combine flap
repair with other techniques.
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Dermal Flap Anoplasty for Trans-sphincteric Anal Fistula
Richard Nelson, Vlasta Podzemny, and Giuseppe Gagliardi
Contents
1 Rationale . .................................................................................... 351
2 Technique ................................ .................................................... 353
3 Other Dermal Flaps . ......................................................................... 356
4 Discussion . ..... . . . . ...... . . . . ....... . . . ..... . . . . . ...... . . . . ...... . . . . ...... . . . . ...... . . . . ... 362
5 Cross-References .......................... ............................................. ..... 363
References ............................ ............................................... ............ 363
Abstract
This chapter is a descriptive compilation of published dermal flap closure of the
internal fistula opening.
22
1 Rationale
Apart from fistulotomy, and the apparently forgotten slow/loose seton, almost all
procedures to cure anal fistula have one thing in common. That is closure of the
internal opening. In some cases this can be done by direct suture of the opening
itself. Also in many cases, including all flap-related procedures, this closure is
reinforced. This is done by layering over the internal closure a flap of mucosa or
dermis or both.
R. Nelson
University of Illinois at Chicago School of Public Health, Epidemiology/Biometry Division,
Chicago, IL, USA
V. Podzemny
General, Emergency and Minimally Invasive Surgery, Careggi University Hospital, Florence, Italy
G. Gagliardi (
University of Illinois at Chicago School of Medicine Department of Surgery, Chicago, IL, USA
Chicago Surgical Clinic, Chicago, IL, USA
© Springer Nature Switzerland AG 2022
C. Ratto et al. (eds.), Anal Fistula and Abscess, Coloproctology,
https://doi.org/10.1007/978-3-030-76670-2_24
*)
351

352 R. Nelson et al.
This chapter will describe the dermal flap anoplasties used to reinforce the inner
fistula opening. Unlike mucosal anoplasties, which are all pedicled flaps, there is
some variation in how the dermal flaps are moved proximally to cover the inner
fistula (Figs. 1, 2, 3, 4, 5, 6, 7, and 8, and Table 1). The island flap dermal anoplasty
for fistula repair will be described in detail. This is an operation that was adapted
from a procedure described by Vandy Hooks (Pearl et al. 1990), for the treatment
either of anal mucosal ectropion or of stenosis. His goal was to find a way to bring
skin into the anal canal with greater mobility, less tension, and improved blood
supply than those dermal flaps that were undermined and that used only a pedicle for
the blood supply (Giordano et al. 2009; Jun and Choi 1999).
Fig. 1 (continued)

22 Dermal Flap Anoplasty for Trans-sphincteric Anal Fistula 353
Fig. 1 Dermal island flap (a) The incision is drawn from the external opening to just proximal to
the internal opening in a patient with cryptoglandular fistula. The flap, once free from the skin and
subcutaneous tissues (b), will assume a vertical orientation. Donor site 2 weeks (c) and 2 months
after surgery (d). (e) Schematic drawing of the procedure. (From Nelson et al. (2000) with
permission)
2 Technique
In the prone jackknife position a patient is examined, and if a seton is present, it is
removed. With a pen a circular incision line is drawn that incl udes the external
opening of the fistula, to the anal verge and proximal to the internal opening of the
fistula, keeping the circle fairly wide (Fig. 1a).

354 R. Nelson et al.
Fig. 2 Anterior dermal island
flap using the vaginal introitus
Once the drawing is complete, an incision is made on the marked line perpendicular to the skin with no undermining of the flap, to limit interruption of the blood
supply to the flap. This must be done with some care. Distally, beyond the external
opening of the fistula, the cutting is not perpendicular but angled away from the flap,
again to preserve as much blood supply as possible. If electrocautery is used during
the dissection, only low power is used. As the circumferential mobilization continues, the flap will spontaneously start to migrate into the anal canal, becoming less
horizontal and more vertical in its orientation, that is, it will “stand up” (Fig. 1b). At
the proximal margin, the border must be freed a bit from the internal sphincter but
without undermining. The internal fistula opening is then excised. The deeper
internal opening can then be closed, usually with only one or two interrupted sutures
of absorbable material. The flap fully mobilized will seem to have shrunk a bit.
When performing the anastomosis of the proximal flap to the rectal mucosa and
internal sphincter, it is important to spread it to the lateral margins of the initial
internal incision. Interrupted absorbable sutures are then made, full thickness in the
flap and to internal sphincter and mucosa proximal to the internal opening closure.
Usually only four to six stitches are needed, and the line is examined for gaps when
complete. No sutures are placed on the lateral margins or posterior or distal margin of
the flap for three reasons. The first is in order not to diminish the blood supply to the
flap through injury or compression of the blood vessels in the island. The second is
that sutures in the anoderm hurt. The third is to avoid any outward tension on
the flap.
This completes the operation. An external open wound will exist from the
mobilization with the external opening of the fistula at the base of the wound. No
effort is made to excise the distal fistula track or curette its lumen. This open wound
is covered with dry dressings and allowed to granulate. The patient is instructed to
bathe the wound. Filling of the defect occurs fairly rapidly, in up to 8 weeks, and
causes very little pain (Fig. 1c, d).
In the beginning this was performed only for lateral fistulas. Because beneath the
flap skin was only subcutaneous fat, it was thought that there would be greater

22 Dermal Flap Anoplasty for Trans-sphincteric Anal Fistula 355
Fig. 3 Dermal advancement flap. Flap creation (a), flap closure (b), and complete schematic
procedure (c). (From Jun and Choi (1999) with permission)
mobility of the flap and not where skin was overlying muscle in the midline.
However it has been found that posterior and anterior fistulas are not difficult to
treat in the same way, with careful dissection and judicious use of cautery. Fistulas
extending from the rectum into the introitus or vagina proper can also be treated this
way, as in the patient in Fig. 2, though the distal flap may not reach the vaginal
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