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346 D. D. E. Zimmerman
pathophysiologic basis was shown. Moreover, this factor is modiable (it is often possible for patients to discontinue smoking perioperatively). In our opinion, it is worthwhile to counsel patients about their smoking behavior and give them the advice to discontinue smoking cigarettes. When stula repair will not be performed on short notice, weight loss may be considered as well.
10.3 Influence of Covering Ostomy
Sonoda and coworkers compared patients undergoing ap repair with and without a covering colostomy within a heterogenous retrospect ive group of patients (Sonoda et al. 2002). Sixty-four patients underwent advancement ap repair with a covering stoma, resulting in a healing rate of 72%. Twenty-ve patients had a covering colostomy. In these patients, advancement ap repair was successful in only 60%. Even though this difference was not statistically signicant, and it seems likely the more challenging cases may have been offered a stoma, this study did not suggest an advantage of a covering stoma. Similar ndings were reported by Mizarahi and coworkers (Mizrahi 2002), even though they had only three patients who had a covering ostomy (Mizrahi et al. 2002). In their excellent review of literature, Soltani and Kaiser (Soltani and Kaiser 2010a) found that in the studies they included, 4,4% of all patients required a stoma. They suggested that although the impact of a stoma on outcome is very likely, they cannot make any meaningful conclusions based on the paucity of specic data. Despite the assumption of these authors, there is no supportive evidence in literature to support the assumption that covering ostomies ameliorate outcome of advancement ap repair.
10.4 Impact of the Use of Draining Setons
Interestingly, as stated before, none of the author s who investigated the role of preoperative seton drainage showed a statistically signicant higher healing rate in patients in whom a seton was placed, before undergoing advancement ap repair. Even though these investigations prompted us to refrain from prior seton placement more often, still a considerable percentage of patients will undergo seton drainage before advancement ap repair, either in the referring hospital or because of excessive inammation on preoperative MRI. Paradoxically, this suggests that the most difcult cases would be prone to undergo seton drainage. Remarkably, not only i s the healing rate in these patients not higher than patients w ithout prior seton drainage, some authors found it to be lower (Sonoda et al. 2002). Seton placement before advancement ap repair is a well-accepted treatment regime. Many surgeons would advocate seton placement is an important preparatory step before ap repair. It could be reasoned that because of the judicious use of setons, good results can be obtained in the more complex group of patients. It is very hard to draw meaningful conclusions from the available literature, apart from the conclusion that the benet of prior seton drainage cannot be proven and is therefore
21 Transanal Advancement Flap Repair 347
questionable. In our opinion, seton placement can still be part of an adequate treatment plan. A thorough curettage followed by placement of a comfortable seton may decrease the amount of active inammation, thereby minimizing the size of external wounds at a later time. However, a good reason for seton placement has to be present. Placement of setons as part of a standardized treatment regimen are not supported by literature in our opinion.

11 Conclusion

In conclusion, advancement ap repair is a well-investigated technique, yielding good results in the treatment of perianal cryptoglandular stulas. It may be expected that 80% of stulas will heal after advancement ap repair. The impact on fecal continence is predictable and will affect about 13% of patients. We advocate the use of thicker aps where possible. There are few modiable factors that seem to effect healing. Smoking cessation and weight loss may be considered. There is no evidence to support the use of diverting stomas. Placement of setons as part of a standardized treatment regimen are not supported by literature. It is unadvisable to combine ap repair with other techniques.

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Dermal Flap Anoplasty for Trans-sphincteric Anal Fistula

Richard Nelson, Vlasta Podzemny, and Giuseppe Gagliardi
Contents
1 Rationale . .................................................................................... 351
2 Technique ................................ .................................................... 353
3 Other Dermal Flaps . ......................................................................... 356
4 Discussion . ..... . . . . ...... . . . . ....... . . . ..... . . . . . ...... . . . . ...... . . . . ...... . . . . ...... . . . . ... 362
5 Cross-References .......................... ............................................. ..... 363
References ............................ ............................................... ............ 363
Abstract
This chapter is a descriptive compilation of published dermal ap closure of the
internal stula opening.
22

1 Rationale

Apart from stulotomy, and the apparently forgotten slow/loose seton, almost all procedures to cure anal stula have one thing in common. That is closure of the internal opening. In some cases this can be done by direct suture of the opening itself. Also in many cases, including all ap-related procedures, this closure is reinforced. This is done by layering over the internal closure a ap of mucosa or dermis or both.
R. Nelson University of Illinois at Chicago School of Public Health, Epidemiology/Biometry Division, Chicago, IL, USA
V. Podzemny General, Emergency and Minimally Invasive Surgery, Careggi University Hospital, Florence, Italy
G. Gagliardi ( University of Illinois at Chicago School of Medicine Department of Surgery, Chicago, IL, USA
Chicago Surgical Clinic, Chicago, IL, USA
© Springer Nature Switzerland AG 2022 C. Ratto et al. (eds.), Anal Fistula and Abscess, Coloproctology,
https://doi.org/10.1007/978-3-030-76670-2_24
*)
351
352 R. Nelson et al.
This chapter will describe the dermal ap anoplasties used to reinforce the innerstula opening. Unlike mucosal anoplasties, which are all pedicled aps, there is some variation in how the dermal aps are moved proximally to cover the innerstula (Figs. 1, 2, 3, 4, 5, 6, 7, and 8, and Table 1). The island ap dermal anoplasty
for stula repair will be described in detail. This is an operation that was adapted from a procedure described by Vandy Hooks (Pearl et al. 1990), for the treatment either of anal mucosal ectropion or of stenosis. His goal was to nd a way to bring skin into the anal canal with greater mobility, less tension, and improved blood supply than those dermal aps that were undermined and that used only a pedicle for the blood supply (Giordano et al. 2009; Jun and Choi 1999).
Fig. 1 (continued)
22 Dermal Flap Anoplasty for Trans-sphincteric Anal Fistula 353
Fig. 1 Dermal island ap (a) The incision is drawn from the external opening to just proximal to the internal opening in a patient with cryptoglandular stula. The ap, once free from the skin and subcutaneous tissues (b), will assume a vertical orientation. Donor site 2 weeks (c) and 2 months after surgery (d). (e) Schematic drawing of the procedure. (From Nelson et al. (2000) with permission)

2 Technique

In the prone jackknife position a patient is examined, and if a seton is present, it is removed. With a pen a circular incision line is drawn that incl udes the external opening of the stula, to the anal verge and proximal to the internal opening of the stula, keeping the circle fairly wide (Fig. 1a).
354 R. Nelson et al.
Fig. 2 Anterior dermal island
ap using the vaginal introitus
Once the drawing is complete, an incision is made on the marked line perpen­dicular to the skin with no undermining of the ap, to limit interruption of the blood supply to the ap. This must be done with some care. Distally, beyond the external opening of the stula, the cutting is not perpendicular but angled away from the ap, again to preserve as much blood supply as possible. If electrocautery is used during the dissection, only low power is used. As the circumferential mobilization con­tinues, the ap will spontaneously start to migrate into the anal canal, becoming less horizontal and more vertical in its orientation, that is, it will stand up(Fig. 1b). At the proximal margin, the border must be freed a bit from the internal sphincter but without undermining. The internal stula opening is then excised. The deeper internal opening can then be closed, usually with only one or two interrupted sutures of absorbable material. The ap fully mobilized will seem to have shrunk a bit. When performing the anastomosis of the proximal ap to the rectal mucosa and internal sphincter, it is important to spread it to the lateral margins of the initial internal incision. Interrupted absorbable sutures are then made, full thickness in the ap and to internal sphincter and mucosa proximal to the internal opening closure. Usually only four to six stitches are needed, and the line is examined for gaps when complete. No sutures are placed on the lateral margins or posterior or distal margin of the ap for three reasons. The rst is in order not to diminish the blood supply to the ap through injury or compression of the blood vessels in the island. The second is that sutures in the anoderm hurt. The third is to avoid any outward tension on the ap.
This completes the operation. An external open wound will exist from the mobilization with the external opening of the stula at the base of the wound. No effort is made to excise the distal stula track or curette its lumen. This open wound is covered with dry dressings and allowed to granulate. The patient is instructed to bathe the wound. Filling of the defect occurs fairly rapidly, in up to 8 weeks, and causes very little pain (Fig. 1c, d).
In the beginning this was performed only for lateral stulas. Because beneath the ap skin was only subcutaneous fat, it was thought that there would be greater
22 Dermal Flap Anoplasty for Trans-sphincteric Anal Fistula 355
Fig. 3 Dermal advancement ap. Flap creation (a), ap closure (b), and complete schematic procedure (c). (From Jun and Choi (1999) with permission)
mobility of the ap and not where skin was overlying muscle in the midline. However it has been found that posterior and anterior stulas are not difcult to treat in the same way, with careful dissection and judicious use of cautery. Fistulas extending from the rectum into the introitus or vagina proper can also be treated this way, as in the patient in Fig. 2, though the distal ap may not reach the vaginal