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20 Utility of Marsupialization Following Anal Fistula Surgery 325
the tract and the skin. This in theory facilitates postoperative healing, with implica­tions on scar tissue formation and bowel continence. We have found the benets of this technique particularly pronounced in obese patients, for whom anal stula operative wounds tend to be deep and more challenging to manage.
In our practice marsupialization is routinely performed for most patients follow­ing stulotomy, except for those with subcutaneous or short intersphincteric stula tracts, as these wounds are often already supercial and small with a relatively uncomplicated postoperative course. Interrupted Vicryl 4-0 is used from the internal to the external apices of the wound. We do not perform stulectomy, i.e., excision of the entire stula tract, at our center.

3 Clinical Evidence

The rst randomized controlled trial to examine the role of marsupialization of analstulotomy wounds was published in Singapore by Ho et al. (1 998). In this study,
103 patients with uncomplicated intersphincteric or transphincteric anal stula were randomized into 2 groups; those who had marsupialization performed and those who did not, following stulotomy. No operative complication was encountered with marsupialization, and the technique led to signicantly quicker (6.0 vs 10 weeks, p < 0.001) and more regular healing of the wound. Marsupialization also led to less instances of incontinence at postoperative 6 weeks (2 vs 12%) and better preserved the maximum anal squeeze pressure on manometric assessment at 3 months follow­ing surgery. This was attributed to the suggestion of less scarring and deformity of the external anal sphincters with a marsupialized wound. The surgery duration was signicantly prolonged by an average of 2 min with the addition of marsupialization (10 vs 8 min, p < 0.05).
A randomized study (Pescatori et al. 2005) from Italy with 46 patients show ed that marsupialization following stulotomy or stulectomy nearly halved the mean size of the intraoperative woun d from 1749 to 819 mm decreased to an average area of 217 mm
2
4 weeks after surgery. Wound size in the non-marsupialized group had a mean size of 543 mm2also measured 4 weeks following surgery. The incidence of postoperative bleeding was also decreased after marsupialization (36% vs 46%, p < 0.05). The decreased wound size did not translate to a signicant difference in postoperative pain.
Interestingly, no study has yet demonstrated a difference in patient-reported pain scores when marsupialization is performed. While it is always difcult to quantify pain objectively, we postulate that the decrease in pain from a smaller raw wound surface follow ing marsupialization may be offset by irritation from the placement of multiple sutures. A randomized trial from Thailand (Sahakitrungruang et al. 2011)of 50 patients with low and uncomplicated stula similarly did not show any difference in postoperative pain with or without marsupialization following stulotomy, but there was a statistically signicant difference in the number of patients who needed pethidine injection (4 vs 13 patients, p ¼ 0.017).
2
( p < 0.001), which then
326 I. Seow-En and F. Seow-Choen
The largest randomized study evalua ting the utility of marsupializat ion for anal stula surgery consisted of 162 patients from Tanzania (Chalya and Mabula 2013). This study randomizing patients into those undergoing stulotomy with marsupia­lization using 3-0 chromic catgut and those undergoing stulectomy without marsupialization. Wound healing was signicantly faster (28.6 vs 36.4 days,
p ¼ 0.002) with wound discharge ceasing signicantly earlier (2.6 vs 4.3 weeks, p ¼ 0.012) in the marsupialization group. There was no statistically signicant
difference in operative duration, wound size, or infection whether or not marsupia­lization was performed.
To date, at least two other prospective randomized trials primarily assessing marsupialization following anal stula surgery have been performed (Jain et al.
2012; Anan et al. 2019), each with relatively small numbers of patients. These
studies consistently show signicantly quicker wound healing times with marsupia­lization and similar or less complication rates when the operative wound is marsupialized.
A recent network meta-analysis by Wang et al. (2017) investigating the best surgical strategy for anal stula included 20 articles with 1663 patients. Of these, 11 studies reported healing time data. After statistical comparison of these studies, stulotomy with marsupialization was found to demonstrate the shortest healing time compared to other treatment options. This surgical strategy also ranked well in the domains of incontinence and stula recurrence, prompting the authors to suggest that the clinical benets of marsupialization may be greater than previ­ously thought.
Limitations of the prospective trials stated in this chapter rstly pertain to their relatively low patient numbers, which may lead to them being underpowered to detect certain differences between the groups . Moreover, in practice clinicians often encounter stula with a wide spectrum of presentations and complexities, but many of the studies only select patients with simple, uncomplicated anal stula. The methods used to measure wound healing, wound size, and other parameters are difcult to standardize and vary from study to study.

4 Conclusion

Management of anal stula remains challenging to surgeons. Current evidence consistently proves that marsupialization in addition to stulotomy reduces wound healing times, likely by improving drainage and decreasing the size of the wound. Although it may take slightly longer to perform operatively, it is an extremely easy and safe technique with a negligible risk prole. While not conclusively proven, marsupialization can decrease wound bleeding and pain and recurrence, as well as improve continence by minimizing anal deformity. In our experience, the advantages of this technique may be particularly pronounced in obese patients, for whom anal stulotomy wounds tend to be deeper and more challenging for the patient and healthcare professionals to manage.
20 Utility of Marsupialization Following Anal Fistula Surgery 327

References

Adams F (1849) The genuine works of Hippocrates translated from the Greek with a preliminary
discourse and annotation. William Wood, New York Anan M, Emile SH, Elgendy H, Shalaby M, Elshobaky A, Abdel-Razik MA, Elbaz SA, Farid M
(2019) Fistulotomy with or without marsupialisation of wound edges in treatment of simple anal
stula: a randomised controlled trial. Ann R Coll Surg Engl 101(7):472–478 Arderne J (1983) Treatises of stula in ano, hemorrhoids, and cylsters. By John Arderne, from an
early fteenth century manuscript translation. Dis Colon Rectum 26(1):74–78 Chalya PL, Mabula JB (2013) Fistulectomy versus stulotomy with marsupialisation in the
treatment of low stula-in-ano: a prospective randomized controlled trial. Tanzan J Health
Res 15(3):193–198 Garcia-Aguilar J, Belmonte C, Wong WD, Goldberg SM, Madoff RD (1996) Anal stula surgery.
Factors associated with recurrence and incontinence. Dis Colon Rectum 39(7):723–729 Ho YH, Tan M, Leong AFPK, Seow-Choen F (1998) Marsupialization of stulotomy wounds
improves healing: a randomized controlled trial. Br J Surg 85(1):105–107 Jain BK, Vaibhaw K, Garg PK, Gupta S, Mohanty D (2012) Comparison of a stulectomy and a
stulotomy with marsupialization in the management of a simple anal stula: a randomized,
controlled pilot trial. J Korean Soc Coloproctol 28(2):78–82 Lowe PA (1612) Discourse of the whole art of Chyrurgerie, 2nd edn. Printed by Thomas Purfoot Pescatori M, Ayabaca SM, Cafaro D, Iannello A, Magrini S (2005) Marsupialization of stulotomy
and stulectomy wounds improves healing and decreases bleeding: a randomized controlled
trial. Color Dis 8(1):11–14 Phillips RKS, Lunniss PJ (1996) Anal stula. Surgical evaluation and management. Chapman &
Hall Medical, London Sahakitrungruang C, Pattana-Arun J, Khomvillai S, Tantiphiachiva K, Atitthamsakul P,
Rojanasakul A (2011) Marsupialization for simple stula in ano: a randomized controlled
trial. J Med Assoc Thail 94(6):699–703 Seow-Choen F, Nicholls RJ (1992) Anal stula. Br J Surg 79(3):197–205 Wang Q, He YK, Shen J (2017) The best surgical strategy for anal stula based on a network meta-
analysis. Oncotarget 8(58):99075–99084 Yang CY (1992) Fistulotomy and marsupialisation for simple stula-in-ano. Singap Med J 33(3):
268–270

Transanal Advancement Flap Repair

David D. E. Zimmerman
Contents
1 Introduction .................... ............................... ............................. 330
2 Nomenclature ................. ............................. ............................. ... 330
3 Effectiveness of the Technique ..................... .......................... ............. 331
4 Effectiveness of Repeat Procedures ....................................................... 332
5 Impact on Fecal Continence .... ................................... ........................ 332
6 Severity of Incontinence ........................ ........................................... 333
7 Perioperative Care .......................................................................... 333
7.1 Bowel Preparation ................................................................... 334
7.2 Antibiotic Prophylaxis .............................................. ................. 334
7.3 Prolonged Antibiotic Therapy ....................................................... 334
7.4 Type of Anesthesia ................................................................... 335
7.5 Immobilization ............................. .......................................... 335
7.6 Bowel Connement . . . . ........................................ ...................... 335
7.7 Stool Softeners ....... ...................................................... .......... 335
7.8 Position . ............... ............................................................... 336
8 Aspects of Surgical Technique ............................................................ 336
8.1 Preoperative Care ................................................................... 336
8.2 Step 1 ...... .................................. ................................... .... 336
8.3 Step 2 ...... .................................. ................................... .... 337
8.4 Step 3 ...... .................................. ................................... .... 337
8.5 Step 4 ...... .................................. ................................... .... 339
8.6 Step 5 ...... .................................. ................................... .... 339
8.7 Postoperative Care .... ........................ ...................................... 339
8.8 Types of Flap ... . . . . ..... . . . . . ....... . . . . ..... . . . . . ....... . . . . ..... . . . . . ....... . . . . . 340
8.9 Shape of Flap ................... ............................................... ..... 341
8.10 Thickness of Flap ................................................................... 341
8.11 Addition of Accessory Techniques ................................................. 342
9 Necessity of Preoperative Imaging .............................. .......................... 343
21
D. D. E. Zimmerman (*) Colorectal Research Group, Department of Surgery, ETZ (Elisabeth – TweeSteden Ziekenhuis) Hospital, Tilburg, The Netherlands e-mail: d.zimmerman@etz.nl
© Springer Nature Switzerland AG 2022 C. Ratto et al. (eds.), Anal Fistula and Abscess, Coloproctology,
https://doi.org/10.1007/978-3-030-76670-2_23
329
330 D. D. E. Zimmerman
10 Factors Contributing to Successful Healing . ...... . . . ...... . . . . ...... . . . .................. 343
10.1 Fistula-Related Factors ................................. ............................ 344
10.2 Patient-Related Factors ... . . . ....... . . . ....... . . . ....... . . . ..... . . . . . ...... . . . . ..... 344
10.3 Inuence of Covering Ostomy ..................................................... 346
10.4 Impact of the Use of Draining Setons ............................................. 346
11 Conclusion ....... ............................... .................................. ......... 347
References ............................ ............................................... ............ 347
Abstract
Transanal advancement ap repair has been around as a treatment modality for transsphincteric perianal stulas for over a century. Several systematic reviews have shown this technique to be effective in 80% of cases with minimal and predictable impact on continence. The use of thicker aps has been shown to increase healing rate, but also to increase the incidence of continence impairment. Unfortunately, there are few modiable factors that seem to effect healing. Smoking cessation and weight loss may be considered. There is no evidence to support the use of diverting stomas. Placement of setons as part of a standardized treatment regimen are not supported by literature. It is unadvisable to combine ap repair with other techniques.
Keywords
Transanal · Advancement · Flap · Endorectal · Fistula · Cryptoglandular · Transsphincteric · Transsncteric · Seton · Perianal

1 Introduction

Even though simple stulas can usually be treated by simple stulotomy (leading to an acceptable decrease in anorectal function), performing stulotomy in more complex stulas will inevitably lead to an unacceptable decrease in anorectal function. For these complex stulas, several sphincter preserving alternatives have been devised. The oldest and best investigated method is undoubtably the transanal advancement ap repair (TAFR) (Zimmerman et al. 2019). This technique has been described under many names (endorectal advancement ap repair, rectal advance­ment ap, mucosal advancement ap) but most authors describe the same or very similar procedures. Even though level 1 evidence involving this procedure is very scarce, best evidence by large reviews as well as high-quality detailed analyses is available.

2 Nomenclature

The transanal advancement ap repair (TAFR) for perianal stulas was, to the best of our knowledge, rst described by Arthur Elting in 1912 (Elting 1912). Throughout the years, many modications to the technique, originally described by Elting were described. Nonetheless, most authors have published their technique under a similar
21 Transanal Advancement Flap Repair 331
name (endorectalor transanaladvancement ap). After several small series were published throughout the twentieth century, the rst large series in recent years was published by Aguilar and coworkers (Aguilar et al. 1985), and they described their technique as a mucosal advancement. Interestingly, like Elting, they described a very dissimilar ap design to the ap most authors have described in the past 20 years. We have always published our technique as Transanal Advancement Flap Repair” in earlier reports (Zimmerman 2019; Schouten et al.
1999). It seems prudent to include the approach in the name of the operation
(transanal or endorectal) as well as the technique (advancement of a ap). Since a wide variety in consistency of the ap has been described including the term rectal or mucosal does not seem useful in uniformly describing the technique. Therefore, the term Advancement Flap Repairis used in this chapter and seems t o be the best name for this type of operation.

3 Effectiveness of the Technique

Even though the reported healing rate o f advancement ap repair va ries widely, with reported healing rates varying between 30% and 100%, most authors surgeons state a healing rate of about two-thirds to their patients . As is the case in many techniques, initial reported healing rat es are very high. The large series by Ag uilar in the 1980s describes an almost perfect healing rate of 98% (Aguilar et al. 1985). This high healing rate motivated many others to start utilizing the technique in orde r to improve the outcome of stula surgery. Unfortunately, other authors were not able to reproduce these results. Decreasing successes were published in the 1990s (Schouten et al. 1999; Kodner et al. 1993;Ozuneretal.
1996), reporting more realistic healing rates varying between 68% and 87%. In an
excellent review covering 35 studies including over 2000 patients, Soltani and coworkers present a weighted average healing rate of 80,8% for cryptoglandular stulas ( Soltani and Kaiser 2010a). This result was also described by Balciscueta and coworkers in a similar review nding a pooled rate of recurrence of 21% (Balciscueta et al. 2017), despite including several large newer studies and disregarding studies of lower quality. The most recent review of Stellingwerf and coworkers (Stellingwerf et al. 2019) nds a somewhat lower weighted healing rate of 69,9%. Interestingly, the authors of this review state to hav e excluded studies in which a core-out stulectomy or dissection of the tract was performed before creating the advancement ap, while man y surgeons would consider this to be inherent part of the operative technique. Interestingly, they did include several large studies that did exactly that (van Onkelen et al. 2014;Uribe et al. 2015; Mushaya et al. 2012), while excluding o ther large series with similar technique. This results in a relatively small pool of only 18 included s tudies, which due to the aforementioned skewed selection seems to be somewhat ran­dom. Because of these ndings and the coherent ndings of the two large reviews mentioned earlier (Balciscueta et al. 2017; Soltani and Kaiser 2010b), expected healing rate of advancement ap repair should be considered to be somewhere around 80%.
332 D. D. E. Zimmerman

4 Effectiveness of Repeat Procedures

Several authors (Kodner et al. 1993; Mizrahi et al. 2002; Jarrar and Church 2011; Mitalas et al. 2007; Stremitzer et al. 2012; Podetta et al. 2019) have published the outcome of repeat ap procedures. Interestingly, without exception a high healing rate is described by these authors. Even though brosis, inammation, and negative patient selection would at rst glance seem to predispose for negative outcome, most authors nd repeat advancement ap repair generally doable. Possibly, surgeon selection plays a role here. Even though almost 4 in 5 surgeons declare they have some form of experience with advancement ap repair (Ratto et al. 2019), less than 15% perform more than 10 procedures per year (Ratto et al. 2019). Moreover, more than half of these surgeons nd advancement ap repair a technically demanding procedure. It is likely that surgeons who have less experience may refer patients with recurring stulas to more experienced surgeons, yielding similar good results.

5 Impact on Fecal Continence

Interestingly, the initial series in the end of the twentieth century hardly entail detailed reports of the impact on fecal continence. The series of Aguilar and coworkers described an impairment of continence in about 10% of cases, whereas Schouten and coworkers report a signicantly higher incidence of impaired conti­nence of 35% (Aguilar et al. 1985; Schouten et al. 1999). It is unclear exactly why patients who undergo advancement ap repair may encounter impaired continence. Even though the external anal sphincter is (supposedly) preserved in all patients, they frequently encounter minor impact on their fecal continence. Even though overt fecal incontinence is rare, minor impairment is a frequent nding, that should be discussed with the patient extensively and be part of shared decision-making. Aguilar attributes this impact on the inclusion of circular muscle bers in the ap (Aguilar et al. 1985). Schouten and coworkers postulated that the use of the Parks retractor was a major contributing factor (Zimmerman et al. 2003a). This phenom­enon was also described by other authors (van Tets et al. 1997). It is difcult to draw meaningful conclusions on this subject; however, there are some indications in literature that the use of this retractor is a major contributing factor to fecal conti­nence impairment. It is rare for published results on ap repair to include detailed information on the impact on fecal continence. However, authors who describe the use of different retractors (such as Hill-Ferguson, Eisenhammer or Scott retractors) report an incidence of impaired continence varying between 0% and 12% (Ortiz et al. 2008; Hyman 1999; Perez et al. 2006), whereas authors who used the Parks retractor report an incidence of impaired continence varying between 28% and 40% (Schouten et al. 1999; van Koperen et al. 2008; Koehler et al. 2004). Moreover, in our own early work, we compared the use of the Parks retractor to the use of the Scott
21 Transanal Advancement Flap Repair 333
retractor and we found both a statistically signicant difference in Rockwood Fecal incontinence Severity Index as well as in postoperative anal resting pressure (Zimmerman et al. 2003a). Lastly, the incidence of impaired continence in our patients dropped from 35% to 4% after discontinuing the use of the Parks retractor (Schouten et al. 1999; Mitalas et al. 2007). The review of Soltani and coworkers calculated a weighted average incontinence rate of 13% (Soltani and Kaiser 2010a). Balciscueta and coworkers (Balciscueta et al. 2017) identied 12 studies utilizing pre- and postoperative incontinence data using validated scores. Since this report only assesses stulas of cryptoglandular origin, it seems to be the most reliable analysis. They report a pooled rate of fecal incontinence of 13,3%. Stellingwerf and coworkers (Stellingwerf et al. 2019) only included nine studies in the analysis concerning fecal continence after advancement ap repair. They describe a weighted incontinence rate of only 7,9%. In conclusion, about 1 in 10 patients wi ll encounter impaired continence after this operation. The inclusion of circular muscle bers and the use of Parks retractor may both play a major contributing role in this.

6 Severity of Incontinence

It has to be noted that it is exceptionally rare for authors to publish detailed report the severity and frequency of impaired continence after advancement ap repair, as Soltani rightfully noticed (Soltani and Kaiser 2010a). The heterogeneity of tools used for reporting is large; moreover, the method of reporting these different scores is also not uniform. Also many studies ov erestimate continence impairment because preoperative continence is rarely noted in detail (and incorrectly fre­quently assumed to be normal). In the rare studies in which specic changes were assessed in patients with normal or abnormal preoperative continence, using validated continence scores (Uribe et al. 2015; Jarrar and Church 2011; Zimmerman et al. 2003a; Uribe Quintana et al. 20 0 9), it is concluded that even though incontinence per se (loss of solid or liquid stool) occurs after advancement ap repair, but is rare, most continence impairment that is observed is minor, and most often consists of soiling alone. In conclusion, the occurrence of impaired continence should be discussed preoperatively with patients in detail, but should be placed in context, and should be described as an impairment of continence, rather than the occurrence of gross incontinence.

7 Perioperative Care

Perioperative care surrounding advancement ap repair is very variable. In order to further obfuscate this matter, consistent and complete description of perioperative measures is seldomly included in reports on this technique.
334 D. D. E. Zimmerman
7.1 Bowel Preparation
Even though the exact type of bowel preparation used in advance of advancement ap repair is not uniformly reported by all authors, some form of preparation seems to be desirable, as gross contamination of the rectum makes dissection both difcult as well as adding an unacceptable and undesirable source of perioperative contam­ination. Whereas several authors prescribe full mechanical bowel preparation (Schouten et al. 1999; Ozuner et al. 199 6 ; Mizrahi et al. 2002; Uribe et al. 2007; Boenicke et al. 2017), some authors (Mushaya et al. 2012; Bessi et al. 2019) describe none at all. Simple preoperative enemas were used frequently as well (Khafagy et al.
2010; Golub et al. 1997; Schwandner 2011; Tan et al. 2012; Bondi et al. 2017). The
impact of specic types of bowel preparation (or the omission of it) was never investigated. Based on current literature, no arguments or evidence exist to support the application of specic types of bowel preparation (or the omission of it) before advancement ap repair. However, from a patient perspective, enemas seem to be preferred over full mechanical bowel prepar ation. As no specic benets of the use of full mechanical bowel preparation in advance of advancement ap repair have been described, we advocate the use of preparation by preoperative enema over the use of mechanical bowel preparation.
7.2 Antibiotic Prophylaxis
Only rarely do authors refrain from applying single shot prophylactic antibiotics. Even though some authors do not mention the use of prophylactic antibiotics, only one author (Golub et al. 1997) specically mentions only applying antibiotic pro­phylaxis in patients with endocarditis or prosthetic joints. Therefor e, this seems to be one of the few items most surgeons would agree upon, and even though no evidence exists to the benet of prophylactic antibiotics for advancement ap repair, the use is so widespread that consensus may be assumed.
7.3 Prolonged Antibiotic Therapy
Several authors have prescribed continued antibiotic therapy after advancement ap repair. A myriad of different regimens have been described. The Rotterdam group (Mitalas et al. 2007; Zimmerman et al. 2003b ) has been a strong proponent of continued intravenous antibiotics in combination with immobilization for 5 days. Other authors use similar regimens (Ozuner et al. 1996; Khafagy et al. 2010; Bondi et al. 2017), but others (Tan et al. 2012) prescribed oral antibiotics for 1 week, to be taken after discharge. However, several authors (Uribe et al. 2007; Golub et al. 1997; Ortiz and Marzo 2000) described large groups of patients who did not receive additional antibiotic therapy with excellent results. A striking (obvious) difference between these groups is the strikingly longer length of stay in patient who are admitted for antibiotic therapy. No differences in outcome seem apparent between
21 Transanal Advancement Flap Repair 335
the two regimens. As there is no consensus in literature on the use of prolonged antibiotic therapy after advancement ap repair, and both regimens with and without its application are in use, it would seem that the longer length of stay is not justied by any proposed discernible benets. The impact of prolonged antibiotic therapy was never investigated. Based on current literature, no argu­ments or evidence exist to support the application of prolonged antibiotic therapy after advancement ap repair.
7.4 Type of Anesthesia
Advancement ap repair can safely be performed either using locoregional anesthe­sia as well as general endotracheal anesthesia. Surgeons preference, or preference of the team or anesthesiologist may play an important role in selecting the type of anesthesia.
7.5 Immobilization
Whereas most authors did not immobilize patients, several authors immobilized their patients after the operation (Jarrar and Church 2011; Mitalas et al. 2007). The impact of immobilization was never investigated. Based on current literature, no arguments or evidence exist to support the application of immobilization after advancement ap repair.
7.6 Bowel Confinement
Several authors have applied different types of bowel connement. In the late 1990s, several authors prescribed opiates or other transit inhibitors in order to postpone bowel movements after the operation (Hyman 1999; Uribe et al. 2007; Golub et al.
1997), others restricted diet to liquids (Mitalas et al. 2007; Uribe et al. 2007;
Boenicke et al. 2017) or even nil-per-mouth (Jarrar and Church 2011). The impact of bowel connement was never investigated. Based on current literature, no arguments or evidence exist to support the application of bowel connement after advancement ap repair.
7.7 Stool Softeners
Almost all authors describe varying types of stool softeners, bers being most prevalent. Compliance of these prescriptions has never been investigated. However, most surgeons would agree upon its use, and even though no evidence exists to the benet of postoperative stool softeners after advancement ap repair, the use is so widespread that consensus may be assumed.