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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_1056_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Preface
- •Contents
- •About the Editors
- •Contributors
- •3 Host Factors: Age, Gender, Lifestyle
- •4 IBD and Other Etiologically Relevant Comorbid Conditions
- •5 Anatomical Presentation and Rectovaginal Fistula
- •6 Anal Fistula Development: Microbiological Factors
- •7 Recurrence and Cancer Risk
- •8 Conclusion
- •References
- •1 Epidemiology of Anal Fistula and Abscess
- •1 Introduction
- •2 Incidence and Prevalence
- •2.1 Europe
- •2.2 USA and Canada
- •2 Anorectal Anatomy Related to Anal Fistula and Abscess
- •1 Introduction
- •2 Mucosal Layer and Submucosal Space
- •3 Internal Anal Sphincter
- •4 Intersphincteric Space and Conjoint Longitudinal Muscle
- •5 External Anal Sphincter
- •6 Pelvic Floor
- •7 Extra-anal Spaces/Ischioanal Fossae
- •8 Anal Glands
- •10 Conclusion
- •11 Cross-References
- •References
- •3 Anorectal Physiology Related to Anal Fistula and Abscess
- •1 Principal Aspects of Anorectal Physiology
- •1.1 Secretory Function of the Anorectum and the Cryptoglandular Hypothesis
- •1.2 Histology and Cellular Physiology of the Anorectum and Fistula
- •1.3 Microbiology and Fistula
- •1.4 Host Factors Relevant to Abscess and Fistula
- •1.5 Anal Continence
- •1.5.1 The Rectum
- •1.5.2 The Musculature of the Pelvic Floor and Sphincter Complex
- •1.6 Defecation
- •1.7 Anorectal Physiology Testing in the Context of Fistula
- •1.7.2 Perioperative Anorectal Physiology Testing
- •2 Conclusion
- •References
- •4 Unconventional Insights in the Pathogenesis and Etiology of Fistulas in the Perianal Region
- •1 Introduction
- •1.1 Etiology
- •1.2 Risk Factors for Development of Perianal Fistula
- •1.3 Risk Factors due to the Type of Perianal Fistula
- •1.4 Treatment-Related Risk Factors for Failure
- •1.5 Preliminary Conclusions
- •2.1 Anatomy of the Anal Canal
- •2.2 Histology of the Anal Canal
- •2.3 Histopathologic Concepts of Perianal Fistulas
- •3.1 Old Stories, New Histopathological Concepts?
- •3.2 Old Stories, New Clinical Concepts?
- •3.2.1 Basic Concepts
- •3.3 Based on Previous Medical History
- •3.4 Aspect and Localization of the Fistula Opening
- •3.5 Phenotype 1
- •3.6 Phenotype 2
- •3.7 Phenotype 3
- •3.8 Phenotype 4
- •3.9 Phenotype 5
- •4 Discussion and Conclusions
- •5 Cross-References
- •References
- •5 From Abscess to Fistula
- •1 Anorectal Abscess
- •References
- •6 Classification of Anal Fistula and Abscess
- •1 Introduction
- •2 Purpose and Attributes of a Classification
- •3 Overview of Anal Fistula Classifications
- •4 Anal Fistula Classifications
- •4.1 Parks Classification
- •4.1.1 Strong Points
- •4.1.2 Weak Points
- •5.1 Strong Points
- •5.2 Weak Points
- •6 Garg Classification
- •6.6 Strong Points
- •6.7 Weak Points
- •7 Status of Extrasphincteric Fistulas
- •8 Evaluation of Existing Classifications on Long-Term Data
- •9 Conclusions
- •References
- •7 Clinical Assessment of Anal Cryptoglandular Abscess and Fistula
- •1 Introduction
- •2 Types of Clinical Evaluation
- •3 Diagnosis
- •4 Topographic Evaluation
- •4.1 The Cryptic Endoanal Primary Opening
- •4.2 The Secondary Opening or Openings
- •4.3 The Main Tract of the Fistula
- •4.4 Possible Purulent Collections
- •1.1 Physical Examination of the Anus and Rectum: General Principles
- •4.5 Possible Secondary Extensions
- •5 Conclusion
- •References
- •8 Clinical Assessment of Crohn Perianal Abscesses and Fistulas
- •1 Introduction
- •1.2 Inspection
- •1.3 Palpation
- •1.4 Endoscopy
- •2 Clinical Presentation
- •2.1 Skin Lesions
- •2.2 Fistulas
- •2.3 Abscesses
- •2.4 Diagnostic Workup
- •2.4.1 General Principles
- •2.5 US
- •2.6 Effectiveness and Sensitivity
- •2.6.1 Endoscopy
- •2.7 MRI
- •2.7.1 CT Scan
- •2.7.2 Fistulography
- •2.8 Diagnostic Follow-up
- •References
- •9 Anorectal Physiology Assessment in Patients with Anal Fistula: When Necessary
- •1 Introduction
- •2 Anorectal Physiology Assessment
- •2.1 Anamnesis
- •2.2 Physical Examination
- •2.3 Anorectal Manometry
- •2.3.1 Equipment
- •2.3.2 Manometry Systems
- •2.4 Neurophysiologic Tests
- •2.4.1 Electromyography
- •2.4.2 Nerve Conduction Studies
- •2.5 Endoanal Ultrasound
- •2.6 Role of Anorectal Physiology Patterns in the Decision-Making
- •3 Discussion
- •References
- •1 Introduction
- •2 Anal Anatomy
- •3 Classification of Fistulas
- •4 EAUS Imaging
- •4.1 Probes EAUS
- •4.2 Performing EAUS
- •4.3 EUS in Perianal Fistulas
- •4.4 Adding Hydrogen Peroxide (H2O2)
- •4.5 Cryptoglandular Fistulas
- •5 Comparison with Other Diagnostic Modalities
- •5.1 Comparison with Surgery
- •5.2 Comparison with MRI
- •5.3 Perineal Ultrasound
- •6 Conclusion and Recommendation
- •References
- •1 Introduction
- •2 Imaging
- •2.1 Conventional Contrast Material-Enhanced Fistulography
- •2.2 CT
- •2.3 Magnetic Resonance Imaging
- •2.3.1 Anatomy MRI
- •2.3.2 MRI Technique (Coils, Volume, and Sequences) and Findings
- •2.3.3 MRI Reconstruction Techniques and Fistulography MRI
- •2.3.4 Internal and Cutaneous Opening
- •2.3.5 Classifications of Perianal Fistulas and Abscesses
- •2.3.6 Deep Posterior Anal Fistulas and Abscess
- •2.3.7 MRI Report
- •2.3.9 MR Role in the Evaluation of the Crypto-Glandular Fistulas
- •3 Conclusion
- •4 Cross-References
- •References
- •1 Introduction
- •2 Clinical Presentation
- •3 Utility and Limitations of Endoanal Ultrasound
- •4 Conclusion
- •5 Cross-References
- •References
- •1 Introduction
- •2 Imaging
- •3 Diagnosis
- •4 MRI Technique
- •5 Disease Monitoring
- •6 Future Directions
- •7 Conclusion
- •8 Cross-References
- •References
- •14 Future Perspectives in the Diagnosis of Anal Fistula and Abscess
- •1 Introduction
- •2 Assessment of Abscess and Anal Fistula
- •3 Abscess
- •3.1 Computed Tomography (CT)
- •3.2 Magnetic Resonance Imaging (MRI)
- •3.3 Endoanal Ultrasound
- •3.4 Transperineal Ultrasonography (TP-US)
- •4 Anal Fistula
- •4.1 Imaging
- •4.1.1 Endoanal Ultrasound
- •4.1.2 Magnetic Resonance Imaging
- •5 Conclusion
- •6 Cross-References
- •References
- •15 How to Drain an Abscess
- •1 Introduction
- •2 Epidemiology and Etiology
- •3 Classification
- •4 Clinical Manifestations and Diagnosis
- •5 Management
- •7 Wound Dressing
- •8 Microbiology and Antibiotics
- •9 General Postoperative Management
- •10 Conclusion
- •11 Cross-References
- •References
- •16 The Seton in Anal Fistula Management
- •1 Introduction
- •2 2500 Years of Setons
- •3 To Put or Not to Put
- •4 To Cut or Not to Cut
- •5 What Kind of Seton to Use?
- •7 Seton 2.0: New Perspectives
- •8 Uncomfortable Questions (How to Do It)
- •9 What Patients Should Know
- •10 Conclusions: Seton in Guidelines
- •References
- •17 Fistulotomy
- •1 Introduction
- •2 Indications
- •3 Fistulotomy: Standard Technique
- •4 Other Fistulotomy Techniques
- •4.1 Addition of Loose Seton
- •4.2 Slow Dissection of the Sphincter: Cutting Seton
- •4.3 Addition of Marsupialization
- •5 Fistulotomy with Immediate Primary Sphincteroplasty (FIPS)
- •7 Postoperative Care
- •8 Complications and Recurrence Rate
- •9 Discussion
- •10 Conclusion
- •References
- •18 Fistulectomy
- •1 Introduction
- •2 Preoperative Evaluation
- •2.1 Patient Selection
- •2.2 Imaging
- •2.3 Physiologic Testing
- •2.4 Endoscopic Examination
- •3 Technique
- •3.1 Patient Preparation
- •3.2 Patient Positioning
- •3.2.1 Technical Steps
- •4 Postoperative Care
- •5 Results
- •5.1 Fistulectomy
- •6 Fistulectomy with Sphincter Reconstruction
- •7 Conclusions
- •References
- •19 Utility of Adding Sphincter Reconstruction to Fistulotomy/Fistulectomy
- •1 Introduction
- •2 General Classification
- •3 Preoperative Preparation
- •4 Surgical Technique Step by Step
- •5 Results
- •6 Conclusion
- •7 Cross-References
- •References
- •20 Utility of Marsupialization Following Anal Fistula Surgery
- •1 Introduction
- •2 Marsupialization
- •3 Clinical Evidence
- •4 Conclusion
- •References
- •21 Transanal Advancement Flap Repair
- •1 Introduction
- •2 Nomenclature
- •3 Effectiveness of the Technique
- •4 Effectiveness of Repeat Procedures
- •5 Impact on Fecal Continence
- •6 Severity of Incontinence
- •7 Perioperative Care
- •7.1 Bowel Preparation
- •7.2 Antibiotic Prophylaxis
- •7.3 Prolonged Antibiotic Therapy
- •7.4 Type of Anesthesia
- •7.5 Immobilization
- •7.6 Bowel Confinement
- •7.7 Stool Softeners
- •7.8 Position
- •8 Aspects of Surgical Technique
- •8.1 Preoperative Care
- •8.2 Step 1
- •8.3 Step 2
- •8.4 Step 3
- •8.5 Step 4
- •8.6 Step 5
- •8.7 Postoperative Care
- •8.8 Types of Flap
- •8.9 Shape of Flap
- •8.10 Thickness of Flap
- •8.11 Addition of Accessory Techniques
- •9 Necessity of Preoperative Imaging
- •10 Factors Contributing to Successful Healing
- •10.1 Fistula-Related Factors
- •10.2 Patient-Related Factors
- •10.3 Influence of Covering Ostomy
- •10.4 Impact of the Use of Draining Setons
- •11 Conclusion
- •References
- •22 Dermal Flap Anoplasty for Trans-sphincteric Anal Fistula
- •1 Rationale
- •2 Technique
- •3 Other Dermal Flaps
- •4 Discussion
- •5 Cross-References
- •References
- •23 (LIFT) Ligation of Intersphincteric Fistula Tract
- •References
- •24 Anal Fistula: Glue and Paste Injection
- •1 Introduction
- •2 Fibrin Glue
- •3 Collagen Paste
- •4 Conclusion
- •5 Cross-References
- •References
- •25 VAAFT
- •1 Introduction
- •1.1 VAAFT Story
- •2 Surgical Equipment and Accessories
- •3 VAAFT Indications
- •3.1 Preoperative Assessment
- •4 VAAFT Procedure
- •4.1 Diagnostic Phase (Fistuloscopy)
- •4.2 Operative Phase
- •5 Closure of the Internal Opening
- •5.1 Use of a Linear or Semicircular Stapler
- •5.2 Advancement Flap
- •5.3 Use of a Bioabsorbable Mesh (Xenograft)
- •5.4 Autologous Dermis Graft
- •5.4.1 VAAFT Associated to the LIFT Procedure
- •5.5 Postoperative Management
- •6 Discussion
- •7 Conclusions
- •References
- •26 The Laser Treatment of Anal Fistulas
- •1 Introduction
- •1.1 Literature Review
- •1.3 Diagnosis and Treatment of Complex Anal Fistulas
- •2 Materials and Methods
- •3 Conclusion
- •References
- •27 Treatment by Over-the-Scope-Clip
- •1 Introduction
- •2 Technical Background
- •3 Surgical Application
- •4 Principle of Action
- •5 Clinical Data
- •References
- •28 Stem Cells in Cryptoglandular Anal Fistulas
- •1 Introduction
- •2 History of a Novel Approach
- •2.1 Mesenchymal Stem Cells
- •2.2 Adipose Tissue: The Ideal MSCs Source
- •2.3 Adipose Tissue Graft
- •2.3.1 Lipogems
- •3 Results
- •3.1 Literature Review
- •3.2 Personal Experience
- •4 Discussion and Conclusion
- •References
- •1 Introduction
- •2 Perianal and Rectovaginal Fistulas
- •2.1 Epidemiology and Diagnosis
- •2.2 Classification
- •2.3 Treatment Modalities
- •3 Flap Reconstruction
- •3.1 Overview and Considerations for Flap Reconstruction
- •4 Gracilis Interposition Flap
- •4.1 Background and Indications
- •4.2 Operative Technique
- •4.3 Results/Complications
- •5 Martius Interposition Flap
- •5.1 History and Indications
- •5.2 Surgical Technique
- •5.3 Results/Complications
- •6 Gluteal Muscle Interposition Flap
- •6.1 History and Indications
- •6.2 Surgical Technique
- •6.3 Results/Complications
- •7 Conclusion
- •References
- •30 Quality of Life Following Anal Fistula Treatment
- •1 Introduction
- •2 Quality of Life with an Anal Fistula
- •2.1 Cryptoglandular Fistulas
- •2.3 Conclusion
- •3 Quality of Life with a Seton and a Fistula

20 Utility of Marsupialization Following Anal Fistula Surgery 325
the tract and the skin. This in theory facilitates postoperative healing, with implications on scar tissue formation and bowel continence. We have found the benefits of
this technique particularly pronounced in obese patients, for whom anal fistula
operative wounds tend to be deep and more challenging to manage.
In our practice marsupialization is routinely performed for most patients following fistulotomy, except for those with subcutaneous or short intersphincteric fistula
tracts, as these wounds are often already superficial and small with a relatively
uncomplicated postoperative course. Interrupted Vicryl 4-0 is used from the internal
to the external apices of the wound. We do not perform fistulectomy, i.e., excision of
the entire fistula tract, at our center.
3 Clinical Evidence
The first randomized controlled trial to examine the role of marsupialization of anal
fistulotomy wounds was published in Singapore by Ho et al. (1 998). In this study,
103 patients with uncomplicated intersphincteric or transphincteric anal fistula were
randomized into 2 groups; those who had marsupialization performed and those who
did not, following fistulotomy. No operative complication was encountered with
marsupialization, and the technique led to significantly quicker (6.0 vs 10 weeks,
p < 0.001) and more regular healing of the wound. Marsupialization also led to less
instances of incontinence at postoperative 6 weeks (2 vs 12%) and better preserved
the maximum anal squeeze pressure on manometric assessment at 3 months following surgery. This was attributed to the suggestion of less scarring and deformity of
the external anal sphincters with a marsupialized wound. The surgery duration was
significantly prolonged by an average of 2 min with the addition of marsupialization
(10 vs 8 min, p < 0.05).
A randomized study (Pescatori et al. 2005) from Italy with 46 patients show ed
that marsupialization following fistulotomy or fistulectomy nearly halved the mean
size of the intraoperative woun d from 1749 to 819 mm
decreased to an average area of 217 mm
2
4 weeks after surgery. Wound size in the
non-marsupialized group had a mean size of 543 mm2also measured 4 weeks
following surgery. The incidence of postoperative bleeding was also decreased
after marsupialization (36% vs 46%, p < 0.05). The decreased wound size did not
translate to a significant difference in postoperative pain.
Interestingly, no study has yet demonstrated a difference in patient-reported pain
scores when marsupialization is performed. While it is always difficult to quantify
pain objectively, we postulate that the decrease in pain from a smaller raw wound
surface follow ing marsupialization may be offset by irritation from the placement of
multiple sutures. A randomized trial from Thailand (Sahakitrungruang et al. 2011)of
50 patients with low and uncomplicated fistula similarly did not show any difference
in postoperative pain with or without marsupialization following fistulotomy, but
there was a statistically significant difference in the number of patients who needed
pethidine injection (4 vs 13 patients, p ¼ 0.017).
2
( p < 0.001), which then

326 I. Seow-En and F. Seow-Choen
The largest randomized study evalua ting the utility of marsupializat ion for anal
fistula surgery consisted of 162 patients from Tanzania (Chalya and Mabula 2013).
This study randomizing patients into those undergoing fistulotomy with marsupialization using 3-0 chromic catgut and those undergoing fistulectomy without
marsupialization. Wound healing was significantly faster (28.6 vs 36.4 days,
p ¼ 0.002) with wound discharge ceasing significantly earlier (2.6 vs 4.3 weeks,
p ¼ 0.012) in the marsupialization group. There was no statistically significant
difference in operative duration, wound size, or infection whether or not marsupialization was performed.
To date, at least two other prospective randomized trials primarily assessing
marsupialization following anal fistula surgery have been performed (Jain et al.
2012; Anan et al. 2019), each with relatively small numbers of patients. These
studies consistently show significantly quicker wound healing times with marsupialization and similar or less complication rates when the operative wound is
marsupialized.
A recent network meta-analysis by Wang et al. (2017) investigating the best
surgical strategy for anal fistula included 20 articles with 1663 patients. Of these,
11 studies reported healing time data. After statistical comparison of these studies,
fistulotomy with marsupialization was found to demonstrate the shortest healing
time compared to other treatment options. This surgical strategy also ranked well in
the domains of incontinence and fistula recurrence, prompting the authors to
suggest that the clinical benefits of marsupialization may be greater than previously thought.
Limitations of the prospective trials stated in this chapter firstly pertain to their
relatively low patient numbers, which may lead to them being underpowered to
detect certain differences between the groups . Moreover, in practice clinicians often
encounter fistula with a wide spectrum of presentations and complexities, but many
of the studies only select patients with simple, uncomplicated anal fistula. The
methods used to measure wound healing, wound size, and other parameters are
difficult to standardize and vary from study to study.
4 Conclusion
Management of anal fistula remains challenging to surgeons. Current evidence
consistently proves that marsupialization in addition to fistulotomy reduces wound
healing times, likely by improving drainage and decreasing the size of the wound.
Although it may take slightly longer to perform operatively, it is an extremely easy
and safe technique with a negligible risk profile. While not conclusively proven,
marsupialization can decrease wound bleeding and pain and recurrence, as well as
improve continence by minimizing anal deformity. In our experience, the advantages
of this technique may be particularly pronounced in obese patients, for whom anal
fistulotomy wounds tend to be deeper and more challenging for the patient and
healthcare professionals to manage.

20 Utility of Marsupialization Following Anal Fistula Surgery 327
References
Adams F (1849) The genuine works of Hippocrates translated from the Greek with a preliminary
discourse and annotation. William Wood, New York
Anan M, Emile SH, Elgendy H, Shalaby M, Elshobaky A, Abdel-Razik MA, Elbaz SA, Farid M
(2019) Fistulotomy with or without marsupialisation of wound edges in treatment of simple anal
fistula: a randomised controlled trial. Ann R Coll Surg Engl 101(7):472–478
Arderne J (1983) Treatises of fistula in ano, hemorrhoids, and cylsters. By John Arderne, from an
early fifteenth century manuscript translation. Dis Colon Rectum 26(1):74–78
Chalya PL, Mabula JB (2013) Fistulectomy versus fistulotomy with marsupialisation in the
treatment of low fistula-in-ano: a prospective randomized controlled trial. Tanzan J Health
Res 15(3):193–198
Garcia-Aguilar J, Belmonte C, Wong WD, Goldberg SM, Madoff RD (1996) Anal fistula surgery.
Factors associated with recurrence and incontinence. Dis Colon Rectum 39(7):723–729
Ho YH, Tan M, Leong AFPK, Seow-Choen F (1998) Marsupialization of fistulotomy wounds
improves healing: a randomized controlled trial. Br J Surg 85(1):105–107
Jain BK, Vaibhaw K, Garg PK, Gupta S, Mohanty D (2012) Comparison of a fistulectomy and a
fistulotomy with marsupialization in the management of a simple anal fistula: a randomized,
controlled pilot trial. J Korean Soc Coloproctol 28(2):78–82
Lowe PA (1612) Discourse of the whole art of Chyrurgerie, 2nd edn. Printed by Thomas Purfoot
Pescatori M, Ayabaca SM, Cafaro D, Iannello A, Magrini S (2005) Marsupialization of fistulotomy
and fistulectomy wounds improves healing and decreases bleeding: a randomized controlled
trial. Color Dis 8(1):11–14
Phillips RKS, Lunniss PJ (1996) Anal fistula. Surgical evaluation and management. Chapman &
Hall Medical, London
Sahakitrungruang C, Pattana-Arun J, Khomvillai S, Tantiphiachiva K, Atitthamsakul P,
Rojanasakul A (2011) Marsupialization for simple fistula in ano: a randomized controlled
trial. J Med Assoc Thail 94(6):699–703
Seow-Choen F, Nicholls RJ (1992) Anal fistula. Br J Surg 79(3):197–205
Wang Q, He YK, Shen J (2017) The best surgical strategy for anal fistula based on a network meta-
analysis. Oncotarget 8(58):99075–99084
Yang CY (1992) Fistulotomy and marsupialisation for simple fistula-in-ano. Singap Med J 33(3):
268–270

Transanal Advancement Flap Repair
David D. E. Zimmerman
Contents
1 Introduction .................... ............................... ............................. 330
2 Nomenclature ................. ............................. ............................. ... 330
3 Effectiveness of the Technique ..................... .......................... ............. 331
4 Effectiveness of Repeat Procedures ....................................................... 332
5 Impact on Fecal Continence .... ................................... ........................ 332
6 Severity of Incontinence ........................ ........................................... 333
7 Perioperative Care .......................................................................... 333
7.1 Bowel Preparation ................................................................... 334
7.2 Antibiotic Prophylaxis .............................................. ................. 334
7.3 Prolonged Antibiotic Therapy ....................................................... 334
7.4 Type of Anesthesia ................................................................... 335
7.5 Immobilization ............................. .......................................... 335
7.6 Bowel Confinement . . . . ........................................ ...................... 335
7.7 Stool Softeners ....... ...................................................... .......... 335
7.8 Position . ............... ............................................................... 336
8 Aspects of Surgical Technique ............................................................ 336
8.1 Preoperative Care ................................................................... 336
8.2 Step 1 ...... .................................. ................................... .... 336
8.3 Step 2 ...... .................................. ................................... .... 337
8.4 Step 3 ...... .................................. ................................... .... 337
8.5 Step 4 ...... .................................. ................................... .... 339
8.6 Step 5 ...... .................................. ................................... .... 339
8.7 Postoperative Care .... ........................ ...................................... 339
8.8 Types of Flap ... . . . . ..... . . . . . ....... . . . . ..... . . . . . ....... . . . . ..... . . . . . ....... . . . . . 340
8.9 Shape of Flap ................... ............................................... ..... 341
8.10 Thickness of Flap ................................................................... 341
8.11 Addition of Accessory Techniques ................................................. 342
9 Necessity of Preoperative Imaging .............................. .......................... 343
21
D. D. E. Zimmerman (*)
Colorectal Research Group, Department of Surgery, ETZ (Elisabeth – TweeSteden Ziekenhuis)
Hospital, Tilburg, The Netherlands
e-mail: d.zimmerman@etz.nl
© Springer Nature Switzerland AG 2022
C. Ratto et al. (eds.), Anal Fistula and Abscess, Coloproctology,
https://doi.org/10.1007/978-3-030-76670-2_23
329

330 D. D. E. Zimmerman
10 Factors Contributing to Successful Healing . ...... . . . ...... . . . . ...... . . . .................. 343
10.1 Fistula-Related Factors ................................. ............................ 344
10.2 Patient-Related Factors ... . . . ....... . . . ....... . . . ....... . . . ..... . . . . . ...... . . . . ..... 344
10.3 Influence of Covering Ostomy ..................................................... 346
10.4 Impact of the Use of Draining Setons ............................................. 346
11 Conclusion ....... ............................... .................................. ......... 347
References ............................ ............................................... ............ 347
Abstract
Transanal advancement flap repair has been around as a treatment modality for
transsphincteric perianal fistulas for over a century. Several systematic reviews
have shown this technique to be effective in 80% of cases with minimal and
predictable impact on continence. The use of thicker flaps has been shown to
increase healing rate, but also to increase the incidence of continence impairment.
Unfortunately, there are few modifiable factors that seem to effect healing.
Smoking cessation and weight loss may be considered. There is no evidence to
support the use of diverting stomas. Placement of setons as part of a standardized
treatment regimen are not supported by literature. It is unadvisable to combine
flap repair with other techniques.
Keywords
Transanal · Advancement · Flap · Endorectal · Fistula · Cryptoglandular ·
Transsphincteric · Transsfincteric · Seton · Perianal
1 Introduction
Even though simple fistulas can usually be treated by simple fistulotomy (leading to
an acceptable decrease in anorectal function), performing fistulotomy in more
complex fistulas will inevitably lead to an unacceptable decrease in anorectal
function. For these complex fistulas, several sphincter preserving alternatives have
been devised. The oldest and best investigated method is undoubtably the transanal
advancement flap repair (TAFR) (Zimmerman et al. 2019). This technique has been
described under many names (endorectal advancement flap repair, rectal advancement flap, mucosal advancement flap) but most authors describe the same or very
similar procedures. Even though level 1 evidence involving this procedure is very
scarce, best evidence by large reviews as well as high-quality detailed analyses is
available.
2 Nomenclature
The transanal advancement flap repair (TAFR) for perianal fistulas was, to the best of
our knowledge, first described by Arthur Elting in 1912 (Elting 1912). Throughout
the years, many modifications to the technique, originally described by Elting were
described. Nonetheless, most authors have published their technique under a similar

21 Transanal Advancement Flap Repair 331
name (“endorectal” or “transanal” advancement flap). After several small series
were published throughout the twentieth century, the first large series in recent
years was published by Aguilar and coworkers (Aguilar et al. 1985), and they
described their technique as a mucosal advancement. Interestingly, like Elting,
they described a very dissimilar flap design to the flap most authors have described
in the past 20 years. We have always published our technique as “Transanal
Advancement Flap Repair” in earlier reports (Zimmerman 2019; Schouten et al.
1999). It seems prudent to include the approach in the name of the operation
(transanal or endorectal) as well as the technique (advancement of a flap). Since a
wide variety in consistency of the flap has been described including the term rectal
or mucosal does not seem useful in uniformly describing the technique. Therefore,
the term “Advancement Flap Repair” is used in this chapter and seems t o be the
best name for this type of operation.
3 Effectiveness of the Technique
Even though the reported healing rate o f advancement flap repair va ries widely,
with reported healing rates varying between 30% and 100%, most authors
surgeons state a healing rate of about two-thirds to their patients . As is the case
in many techniques, initial reported healing rat es are very high. The large series
by Ag uilar in the 1980s describes an almost perfect healing rate of 98% (Aguilar
et al. 1985). This high healing rate motivated many others to start utilizing the
technique in orde r to improve the outcome of fistula surgery. Unfortunately, other
authors were not able to reproduce these results. Decreasing successes were
published in the 1990s (Schouten et al. 1999; Kodner et al. 1993;Ozuneretal.
1996), reporting more realistic healing rates varying between 68% and 87%. In an
excellent review covering 35 studies including over 2000 patients, Soltani and
coworkers present a weighted average healing rate of 80,8% for cryptoglandular
fistulas ( Soltani and Kaiser 2010a). This result was also described by Balciscueta
and coworkers in a similar review finding a pooled rate of recurrence of 21%
(Balciscueta et al. 2017), despite including several large newer studies and
disregarding studies of lower quality. The most recent review of Stellingwerf
and coworkers (Stellingwerf et al. 2019) finds a somewhat lower weighted
healing rate of 69,9%. Interestingly, the authors of this review state to hav e
excluded studies in which a core-out fistulectomy or dissection of the tract was
performed before creating the advancement flap, while man y surgeons would
consider this to be inherent part of the operative technique. Interestingly, they did
include several large studies that did exactly that (van Onkelen et al. 2014;Uribe
et al. 2015; Mushaya et al. 2012), while excluding o ther large series with similar
technique. This results in a relatively small pool of only 18 included s tudies,
which due to the aforementioned skewed selection seems to be somewhat random. Because of these findings and the coherent findings of the two large reviews
mentioned earlier (Balciscueta et al. 2017; Soltani and Kaiser 2010b), expected
healing rate of advancement flap repair should be considered to be somewhere
around 80%.

332 D. D. E. Zimmerman
4 Effectiveness of Repeat Procedures
Several authors (Kodner et al. 1993; Mizrahi et al. 2002; Jarrar and Church 2011;
Mitalas et al. 2007; Stremitzer et al. 2012; Podetta et al. 2019) have published the
outcome of repeat flap procedures. Interestingly, without exception a high healing
rate is described by these authors. Even though fibrosis, inflammation, and negative
patient selection would at first glance seem to predispose for negative outcome, most
authors find repeat advancement flap repair generally doable. Possibly, surgeon
selection plays a role here. Even though almost 4 in 5 surgeons declare they have
some form of experience with advancement flap repair (Ratto et al. 2019), less than
15% perform more than 10 procedures per year (Ratto et al. 2019). Moreover, more
than half of these surgeons find advancement flap repair a technically demanding
procedure. It is likely that surgeons who have less experience may refer patients with
recurring fistulas to more experienced surgeons, yielding similar good results.
5 Impact on Fecal Continence
Interestingly, the initial series in the end of the twentieth century hardly entail
detailed reports of the impact on fecal continence. The series of Aguilar and
coworkers described an impairment of continence in about 10% of cases, whereas
Schouten and coworkers report a significantly higher incidence of impaired continence of 35% (Aguilar et al. 1985; Schouten et al. 1999). It is unclear exactly why
patients who undergo advancement flap repair may encounter impaired continence.
Even though the external anal sphincter is (supposedly) preserved in all patients,
they frequently encounter minor impact on their fecal continence. Even though overt
fecal incontinence is rare, minor impairment is a frequent finding, that should be
discussed with the patient extensively and be part of shared decision-making.
Aguilar attributes this impact on the inclusion of circular muscle fibers in the flap
(Aguilar et al. 1985). Schouten and coworkers postulated that the use of the Parks
retractor was a major contributing factor (Zimmerman et al. 2003a). This phenomenon was also described by other authors (van Tets et al. 1997). It is difficult to draw
meaningful conclusions on this subject; however, there are some indications in
literature that the use of this retractor is a major contributing factor to fecal continence impairment. It is rare for published results on flap repair to include detailed
information on the impact on fecal continence. However, authors who describe the
use of different retractors (such as Hill-Ferguson, Eisenhammer or Scott retractors)
report an incidence of impaired continence varying between 0% and 12% (Ortiz
et al. 2008; Hyman 1999; Perez et al. 2006), whereas authors who used the Parks
retractor report an incidence of impaired continence varying between 28% and 40%
(Schouten et al. 1999; van Koperen et al. 2008; Koehler et al. 2004). Moreover, in
our own early work, we compared the use of the Parks retractor to the use of the Scott

21 Transanal Advancement Flap Repair 333
retractor and we found both a statistically significant difference in Rockwood Fecal
incontinence Severity Index as well as in postoperative anal resting pressure
(Zimmerman et al. 2003a). Lastly, the incidence of impaired continence in our
patients dropped from 35% to 4% after discontinuing the use of the Parks retractor
(Schouten et al. 1999; Mitalas et al. 2007). The review of Soltani and coworkers
calculated a weighted average incontinence rate of 13% (Soltani and Kaiser 2010a).
Balciscueta and coworkers (Balciscueta et al. 2017) identified 12 studies utilizing
pre- and postoperative incontinence data using validated scores. Since this report
only assesses fistulas of cryptoglandular origin, it seems to be the most reliable
analysis. They report a pooled rate of fecal incontinence of 13,3%. Stellingwerf and
coworkers (Stellingwerf et al. 2019) only included nine studies in the analysis
concerning fecal continence after advancement flap repair. They describe a weighted
incontinence rate of only 7,9%. In conclusion, about 1 in 10 patients wi ll encounter
impaired continence after this operation. The inclusion of circular muscle fibers and
the use of Parks retractor may both play a major contributing role in this.
6 Severity of Incontinence
It has to be noted that it is exceptionally rare for authors to publish detailed report the
severity and frequency of impaired continence after advancement flap repair, as
Soltani rightfully noticed (Soltani and Kaiser 2010a). The heterogeneity of tools
used for reporting is large; moreover, the method of reporting these different scores
is also not uniform. Also many studies ov erestimate continence impairment
because preoperative continence is rarely noted in detail (and incorrectly frequently assumed to be normal). In the rare studies in which specific changes
were assessed in patients with normal or abnormal preoperative continence,
using validated continence scores (Uribe et al. 2015; Jarrar and Church 2011;
Zimmerman et al. 2003a; Uribe Quintana et al. 20 0 9), it is concluded that even
though incontinence per se (loss of solid or liquid stool) occurs after advancement
flap repair, but is rare, most continence impairment that is observed is minor, and
most often consists of soiling alone. In conclusion, the occurrence of impaired
continence should be discussed preoperatively with patients in detail, but should be
placed in context, and should be described as an impairment of continence, rather
than the occurrence of gross incontinence.
7 Perioperative Care
Perioperative care surrounding advancement flap repair is very variable. In order to
further obfuscate this matter, consistent and complete description of perioperative
measures is seldomly included in reports on this technique.

334 D. D. E. Zimmerman
7.1 Bowel Preparation
Even though the exact type of bowel preparation used in advance of advancement
flap repair is not uniformly reported by all authors, some form of preparation seems
to be desirable, as gross contamination of the rectum makes dissection both difficult
as well as adding an unacceptable and undesirable source of perioperative contamination. Whereas several authors prescribe full mechanical bowel preparation
(Schouten et al. 1999; Ozuner et al. 199 6 ; Mizrahi et al. 2002; Uribe et al. 2007;
Boenicke et al. 2017), some authors (Mushaya et al. 2012; Bessi et al. 2019) describe
none at all. Simple preoperative enemas were used frequently as well (Khafagy et al.
2010; Golub et al. 1997; Schwandner 2011; Tan et al. 2012; Bondi et al. 2017). The
impact of specific types of bowel preparation (or the omission of it) was never
investigated. Based on current literature, no arguments or evidence exist to support
the application of specific types of bowel preparation (or the omission of it) before
advancement flap repair. However, from a patient perspective, enemas seem to be
preferred over full mechanical bowel prepar ation. As no specific benefits of the use
of full mechanical bowel preparation in advance of advancement flap repair have
been described, we advocate the use of preparation by preoperative enema over the
use of mechanical bowel preparation.
7.2 Antibiotic Prophylaxis
Only rarely do authors refrain from applying single shot prophylactic antibiotics.
Even though some authors do not mention the use of prophylactic antibiotics, only
one author (Golub et al. 1997) specifically mentions only applying antibiotic prophylaxis in patients with endocarditis or prosthetic joints. Therefor e, this seems to be
one of the few items most surgeons would agree upon, and even though no evidence
exists to the benefit of prophylactic antibiotics for advancement flap repair, the use is
so widespread that consensus may be assumed.
7.3 Prolonged Antibiotic Therapy
Several authors have prescribed continued antibiotic therapy after advancement flap
repair. A myriad of different regimens have been described. The Rotterdam group
(Mitalas et al. 2007; Zimmerman et al. 2003b ) has been a strong proponent of
continued intravenous antibiotics in combination with immobilization for 5 days.
Other authors use similar regimens (Ozuner et al. 1996; Khafagy et al. 2010; Bondi
et al. 2017), but others (Tan et al. 2012) prescribed oral antibiotics for 1 week, to be
taken after discharge. However, several authors (Uribe et al. 2007; Golub et al. 1997;
Ortiz and Marzo 2000) described large groups of patients who did not receive
additional antibiotic therapy with excellent results. A striking (obvious) difference
between these groups is the strikingly longer length of stay in patient who are
admitted for antibiotic therapy. No differences in outcome seem apparent between

21 Transanal Advancement Flap Repair 335
the two regimens. As there is no consensus in literature on the use of prolonged
antibiotic therapy after advancement flap repair, and both regimens with and
without its application are in use, it would seem that the longer length of stay is
not justified by any proposed discernible benefits. The impact of prolonged
antibiotic therapy was never investigated. Based on current literature, no arguments or evidence exist to support the application of prolonged antibiotic therapy
after advancement flap repair.
7.4 Type of Anesthesia
Advancement flap repair can safely be performed either using locoregional anesthesia as well as general endotracheal anesthesia. Surgeons preference, or preference of
the team or anesthesiologist may play an important role in selecting the type of
anesthesia.
7.5 Immobilization
Whereas most authors did not immobilize patients, several authors immobilized
their patients after the operation (Jarrar and Church 2011; Mitalas et al. 2007). The
impact of immobilization was never investigated. Based on current literature, no
arguments or evidence exist to support the application of immobilization after
advancement flap repair.
7.6 Bowel Confinement
Several authors have applied different types of bowel confinement. In the late 1990s,
several authors prescribed opiates or other transit inhibitors in order to postpone
bowel movements after the operation (Hyman 1999; Uribe et al. 2007; Golub et al.
1997), others restricted diet to liquids (Mitalas et al. 2007; Uribe et al. 2007;
Boenicke et al. 2017) or even nil-per-mouth (Jarrar and Church 2011). The impact
of bowel confinement was never investigated. Based on current literature, no
arguments or evidence exist to support the application of bowel confinement after
advancement flap repair.
7.7 Stool Softeners
Almost all authors describe varying types of stool softeners, fibers being most
prevalent. Compliance of these prescriptions has never been investigated. However,
most surgeons would agree upon its use, and even though no evidence exists to the
benefit of postoperative stool softeners after advancement flap repair, the use is so
widespread that consensus may be assumed.
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