The realm of knee and hip rehabilitation, encompassing research on wear and fric­tion mechanisms, is a multifaceted arena that extends beyond the immediate scope of implant longevity and material selection. By exploring pivotal factors such as biological responses to wear debris, regulatory standards, and patient-specic con­siderations, this comprehensive review has illuminated a rich tapestry of consider­ations essential for optimizing prosthetic performance. The study has underlined the pivotal role of clinical standards, underscored the clinical signicance of wear and friction in various hip and knee replacements, and delineated the diverse types of wear in these joints. The exploration of materials, from traditional metallic and ceramic implants to the burgeoning realm of composite and surface-modied implants, has underscored the evolving landscape of wear-resistant materials. The pivotal role of synovial uid and the potential of biomimetic approaches have been explored in the realm of lubrication strategies. The discussion on surface coatings for wear resistance, encompassing hydroxyapatite, diamond-like carbon, and nano­composite coatings, has elucidated the wealth of options available to mitigate wear. Further, the review has delved into experimental methodologies like pin-on-disk testing and tribo-corrosion testing, showcasing the diverse tools researchers wield to understand wear and friction mechanisms. Notably, exploring future directions, including additive manufacturing for custom implants and the integration of smart implants, has offered a glimpse into the potential of emerging technologies to revo­lutionize prosthetic wear performance.